Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | HCC38 | -4.4776 | 0.7476 | -4.9435 | -4.4776 | -4.9022 | 3.9980 | 0.5579 | 0.5639 | 8.6262 |
| PD173074 | HCC1569 | -4.4776 | 0.9700 | -5.0968 | -5.0968 | -5.2307 | 2.3460 | 0.0000 | 0.0341 | 7.3805 |
| PD173074 | HCC1428 | -4.4776 | 0.9713 | -5.1368 | -5.1367 | -5.3555 | 2.3020 | 0.0000 | 0.0295 | 7.2858 |
| GSK461364 | SUM229PE | -4.4776 | 0.9292 | -7.8106 | -7.6590 | -7.7933 | 4.0000 | 0.3759 | 0.3759 | 5.7423 |
| Gefitinib | HCC70 | -4.4776 | 0.8897 | -4.4921 | -4.5561 | -5.0812 | 0.9805 | 0.0000 | 0.5169 | 8.0439 |
| PD173074 | HCC1419 | -4.4776 | 0.7651 | -4.2805 | -4.4776 | -5.1784 | 1.1525 | 0.0000 | 0.6269 | 8.3843 |
| PD173074 | HCC1395 | -4.4776 | 0.9577 | -5.5896 | -5.5895 | -6.1550 | 0.5878 | 0.0000 | 0.1817 | 6.7448 |
| GSK461364 | HCC1143 | -4.4776 | 0.8745 | -6.5206 | -6.4846 | -7.1518 | 2.1907 | 0.1222 | 0.2496 | 5.9762 |
| PD173074 | HCC1143 | -4.4776 | 0.9259 | -4.8148 | -4.7874 | -4.9249 | 1.7550 | 0.0524 | 0.2455 | 8.1306 |
| GSK461364 | Hs 578T | -4.4776 | 0.9074 | -7.7706 | -7.6340 | -7.8504 | 2.5630 | 0.2968 | 0.2968 | 5.2331 |
| GSK1070916 | MDA-MB-134-VI | -4.4776 | 0.8155 | -4.5868 | -4.5868 | -5.5744 | 0.5597 | 0.0000 | 0.4864 | 7.9183 |
| Gefitinib | HCC202 | -4.4776 | 0.8987 | -4.9372 | -4.9372 | -6.0592 | 0.8082 | 0.0000 | 0.2980 | 7.7021 |
| Gefitinib | Hs 578T | -4.4776 | 0.8184 | -4.7687 | -4.7686 | -4.8241 | 2.3305 | 0.0001 | 0.2335 | 8.3697 |
| PD173074 | BT-549 | -4.4776 | 0.9379 | -5.0909 | -5.0909 | -5.1028 | 2.5840 | 0.0000 | 0.0254 | 7.9333 |
| GSK1070916 | HCC70 | -4.4776 | 0.8789 | -5.6596 | -5.6592 | -6.4477 | 0.4719 | 0.0000 | 0.2000 | 6.6848 |
| GSK1070916 | Hs 578T | -4.4776 | 0.9154 | -5.9386 | -5.9390 | -6.4229 | 0.5351 | 0.0000 | 0.1410 | 6.1417 |
| PD173074 | BT-474 | -4.4776 | 0.9345 | -4.8460 | -4.8119 | -4.9537 | 4.0000 | 0.1345 | 0.1627 | 8.3440 |
| PD173074 | BT-20 | -4.4776 | 0.8027 | -5.0040 | -4.8614 | -5.1114 | 4.0000 | 0.3654 | 0.3703 | 8.6204 |
| GSK461364 | SUM185PE | -4.4776 | 0.8273 | -5.1574 | -5.1573 | -5.8411 | 1.7260 | 0.0000 | 0.0879 | 7.3788 |
| GSK1070916 | MDA-MB-157 | -4.4776 | 0.7855 | -5.6706 | -5.6709 | -5.9571 | 0.4644 | 0.0000 | 0.2182 | 6.4360 |
| PD173074 | AU565 | -4.4776 | 0.9380 | -5.1283 | -5.0852 | -5.1382 | 3.9970 | 0.1635 | 0.1656 | 8.0550 |
| PD173074 | MDA-MB-231 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.7436 |
| GSK461364 | HCC70 | -4.4776 | 0.8008 | -7.0721 | -5.1370 | -7.5055 | 2.2167 | 0.2518 | 0.3533 | 6.3285 |
| PD173074 | SK-BR-3 | -4.4776 | 0.9752 | -4.9176 | -4.9175 | -4.9949 | 1.9200 | 0.0000 | 0.1251 | 7.7539 |
| GSK461364 | SUM159PT | -4.4776 | 0.9804 | -7.5366 | -7.5215 | -7.5669 | 3.9990 | 0.0630 | 0.0630 | 4.5877 |