Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Taxol | T47D | -4.4776 | 0.9623 | -8.0116 | -6.0775 | -8.0746 | 3.9980 | 0.4890 | 0.4890 | 6.2255 |
| GSK461364 | HCC1569 | -4.4776 | 0.7965 | -5.0714 | -5.0714 | -5.7745 | 0.3696 | 0.0000 | 0.3763 | 6.5207 |
| Taxol | ZR-75-1 | -4.4776 | 0.9309 | -7.9131 | -4.4776 | -7.7855 | 2.7500 | 0.7078 | 0.7078 | 7.4720 |
| GSK1070916 | MDA-MB-436 | -4.4776 | 0.7907 | -6.4626 | -5.9265 | -6.7461 | 0.6887 | 0.2865 | 0.3159 | 6.8143 |
| GSK1070916 | UACC-812 | -4.4776 | 0.7401 | -5.0020 | -4.4776 | -5.0814 | 3.9990 | 0.6105 | 0.6136 | 9.2304 |
| GSK461364 | MDA-MB-468 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 3.8650 |
| Gefitinib | CAMA-1 | -4.4776 | 0.7673 | -4.6501 | -4.4776 | -4.6796 | 3.9950 | 0.3020 | 0.6232 | 8.7188 |
| Taxol | SUM149PT | -4.4776 | 0.9614 | -8.1036 | -8.0475 | -8.1202 | 4.0000 | 0.2002 | 0.2002 | 4.7283 |
| Taxol | SUM159PT | -4.4776 | 0.9820 | -8.4646 | -8.4355 | -8.4836 | 2.2040 | 0.0682 | 0.0682 | 3.1856 |
| Taxol | SUM52PE | -4.4776 | 0.9808 | -8.4026 | -7.9916 | -8.3327 | 2.0320 | 0.2643 | 0.2643 | 4.6139 |
| Taxol | 184A1 | -4.4776 | 0.8586 | -7.7586 | -4.4776 | -7.1300 | 1.5600 | 0.6613 | 0.6613 | 7.5136 |
| Taxol | T47DKBLUC | -4.4776 | 0.9657 | -7.7956 | -7.1535 | -7.8857 | 1.9630 | 0.4725 | 0.4725 | 6.3425 |
| Taxol | 600MPE | -4.4776 | 0.8702 | -5.8493 | -4.4776 | -7.3586 | 1.0005 | 0.3500 | 0.6349 | 7.7967 |
| GSK1070916 | BT-483 | -4.4776 | 0.8340 | -4.5853 | -4.4776 | -5.3674 | 0.9554 | 0.0000 | 0.5396 | 8.0951 |
| GSK1070916 | AU565 | -4.4776 | 0.7600 | -5.2504 | -5.2504 | -5.5873 | 0.5535 | 0.0000 | 0.2719 | 6.7505 |
| GSK461364 | MDA-MB-134-VI | -4.4776 | 0.7987 | -4.7865 | -4.6231 | -4.9107 | 3.9995 | 0.0159 | 0.2089 | 7.6944 |
| GSK1070916 | BT-474 | -4.4776 | 0.9390 | -4.8892 | -4.8892 | -5.1976 | 1.5185 | 0.0000 | 0.1965 | 7.9844 |
| Taxol | BT-549 | -4.4776 | 0.9814 | -8.1951 | -8.1066 | -8.1839 | 3.1955 | 0.2355 | 0.2355 | 4.5825 |
| PD173074 | MDA-MB-453 | -4.4776 | 0.9366 | -5.2996 | -5.2994 | -5.7672 | 0.7388 | 0.0000 | 0.1831 | 7.2012 |
| PD173074 | MDA-MB-436 | -4.4776 | 0.9492 | -5.0428 | -5.0428 | -5.1998 | 1.5480 | 0.0000 | 0.1177 | 7.5471 |
| GSK461364 | SK-BR-3 | -4.4776 | 0.8909 | -7.6476 | -7.5380 | -7.6994 | 3.9790 | 0.3129 | 0.3129 | 5.8281 |
| PD173074 | MDA-MB-361 | -4.4776 | 0.9419 | -4.7887 | -4.7887 | -4.6550 | 3.3020 | 0.0000 | 0.0858 | 8.3236 |
| GSK461364 | MCF12A | -4.4776 | 0.7888 | -5.5836 | -5.5839 | -5.8310 | 0.4970 | 0.0000 | 0.2199 | 6.8984 |
| GSK1070916 | MDA-MB-231 | -4.4776 | 0.8912 | -5.4548 | -5.4547 | -5.5379 | 0.9323 | 0.0000 | 0.1121 | 6.9162 |
| GSK1070916 | BT-549 | -4.4776 | 0.9202 | -5.5546 | -5.5550 | -5.7306 | 1.1150 | 0.0000 | 0.0592 | 6.7898 |