Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Afatinib | SUM225CWN | -4.1759 | 0.9306 | -7.2619 | -7.1185 | -7.9561 | 0.5364 | 0.0814 | 0.1012 | 4.5543 |
| Geldanamycin | HCC202 | -4.0000 | 0.9273 | -7.4380 | -6.5325 | -7.9531 | 0.9980 | 0.4376 | 0.4378 | 5.9257 |
| Vinorelbine | UACC-893 | -4.3335 | 0.8850 | -7.8855 | -7.8115 | -7.9526 | 3.9990 | 0.2465 | 0.2465 | 4.7839 |
| Gemcitabine | MDA-MB-453 | -3.8416 | 0.9232 | -7.9436 | -5.8467 | -7.9523 | 2.9725 | 0.4122 | 0.4122 | 5.3277 |
| Omipalisib | LY2 | -4.4776 | 0.9684 | -7.7116 | -7.6721 | -7.9504 | 1.3520 | 0.0577 | 0.0577 | 4.3944 |
| Gemcitabine | SK-BR-3 | -3.8416 | 0.9240 | -7.9446 | -5.8528 | -7.9490 | 3.9990 | 0.4263 | 0.4263 | 5.4749 |
| Vinorelbine | CAMA-1 | -4.3335 | 0.8546 | -7.8915 | -7.7976 | -7.9419 | 3.9990 | 0.2885 | 0.2885 | 5.0736 |
| Taxol | HCC1419 | -4.4776 | 0.8868 | -7.8856 | -4.4776 | -7.9362 | 2.2600 | 0.7390 | 0.7390 | 8.0537 |
| GSK923295 | HCC202 | -4.4776 | 0.8563 | -6.1138 | -5.6744 | -7.9337 | 0.5921 | 0.2096 | 0.4360 | 6.6078 |
| GSK1070916 | HCC1187 | -4.4776 | 0.9555 | -7.8256 | -7.7783 | -7.9254 | 3.9990 | 0.2321 | 0.2321 | 5.1468 |
| Geldanamycin | MDA-MB-361 | -4.0000 | 0.9906 | -7.7620 | -7.7279 | -7.9231 | 3.9970 | 0.1620 | 0.1620 | 4.1263 |
| Taxol | HCC1569 | -4.4776 | 0.9339 | -8.0131 | -4.4776 | -7.9203 | 3.9975 | 0.5523 | 0.5523 | 6.5838 |
| Docetaxel | T47DKBLUC | -5.0000 | 0.9620 | -7.7980 | -7.3631 | -7.9166 | 1.9650 | 0.4303 | 0.4303 | 6.4961 |
| Vinorelbine | HCC38 | -4.3335 | 0.9214 | -7.7570 | -7.6518 | -7.9162 | 2.5860 | 0.1921 | 0.1922 | 4.5617 |
| Geldanamycin | MDA-MB-453 | -4.0000 | 0.9475 | -7.8420 | -7.7885 | -7.9081 | 3.9980 | 0.2197 | 0.2197 | 4.2811 |
| Afatinib | SK-BR-3 | -4.1759 | 0.9367 | -7.7099 | -7.6424 | -7.9074 | 1.3890 | 0.0967 | 0.0967 | 3.8403 |
| Topotecan | SK-BR-3 | -3.9626 | 0.9775 | -7.2166 | -7.0815 | -7.9071 | 0.9831 | 0.1281 | 0.1324 | 4.5646 |
| Ixabepilone | T47D | -4.4045 | 0.9194 | -7.7495 | -7.5412 | -7.8976 | 1.3420 | 0.2373 | 0.2373 | 5.1704 |
| GSK461364 | MDA-MB-436 | -4.4776 | 0.8119 | -7.8636 | -7.3063 | -7.8969 | 2.3230 | 0.3729 | 0.3729 | 6.0263 |
| Vinorelbine | MDA-MB-134-VI | -4.3335 | 0.7975 | -7.7635 | -7.5799 | -7.8968 | 3.1780 | 0.3601 | 0.3601 | 5.5120 |
| Docetaxel | UACC-893 | -5.0000 | 0.8516 | -7.7670 | -7.4530 | -7.8897 | 3.9970 | 0.4722 | 0.4722 | 7.5379 |
| Docetaxel | HCC1419 | -5.0000 | 0.7471 | -7.7670 | -5.0000 | -7.8886 | 1.6530 | 0.7057 | 0.7057 | 8.4471 |
| Vinorelbine | BT-483 | -4.3335 | 0.8002 | -7.3945 | -6.8854 | -7.8878 | 0.9524 | 0.3364 | 0.3372 | 5.7933 |
| Gemcitabine | AU565 | -3.8416 | 0.9938 | -7.7556 | -7.6986 | -7.8877 | 2.5020 | 0.1406 | 0.1406 | 3.7074 |
| Geldanamycin | SK-BR-3 | -4.0000 | 0.9704 | -7.8485 | -7.4310 | -7.8868 | 1.7040 | 0.3960 | 0.3960 | 5.6592 |