Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Imatinib | MDA-MB-361 | -3.2480 | 0.9895 | -4.4620 | -4.4600 | -4.6177 | 3.8790 | 0.0054 | 0.0054 | 6.8426 |
| MG-132 | HCC38 | -4.1759 | 0.9658 | -6.6144 | -6.6129 | -6.7053 | 3.0440 | 0.0055 | 0.0055 | 4.8855 |
| Oxamflatin | HCC1187 | -4.1759 | 0.9877 | -5.9269 | -5.9264 | -6.2188 | 1.3320 | 0.0008 | 0.0055 | 5.9927 |
| NSC 663284 | HCC3153 | -3.7773 | 0.9773 | -5.5128 | -5.5113 | -5.6765 | 2.6810 | 0.0056 | 0.0056 | 6.1192 |
| Imatinib | BT-483 | -3.2480 | 0.9598 | -4.3210 | -4.3198 | -4.5408 | 3.4310 | 0.0054 | 0.0056 | 6.5886 |
| Carboplatin | AU565 | -2.8697 | 0.9747 | -4.6382 | -4.6380 | -4.9765 | 1.2765 | 0.0000 | 0.0056 | 5.9440 |
| Oxaliplatin | BT-549 | -3.2013 | 0.9795 | -5.6888 | -5.6724 | -5.8497 | 0.9202 | 0.0000 | 0.0056 | 5.0972 |
| IKK16 | MCF12A | -4.1759 | 0.9803 | -5.4249 | -5.4239 | -5.4705 | 3.6660 | 0.0056 | 0.0056 | 6.6153 |
| Sunitinib | 600MPE | -3.7773 | 0.9440 | -5.1878 | -5.1875 | -5.4358 | 2.6935 | 0.0032 | 0.0056 | 6.2428 |
| CGC-11144 | MDA-MB-157 | -3.1500 | 0.9911 | -6.7985 | -6.7957 | -7.0163 | 1.9580 | 0.0057 | 0.0057 | 3.3156 |
| Fascaplysin | HCC1937 | -4.4776 | 0.9884 | -6.3396 | -6.3380 | -6.4588 | 2.5715 | 0.0056 | 0.0057 | 5.8011 |
| Oxamflatin | MDA-MB-361 | -4.1759 | 0.9780 | -5.7989 | -5.7974 | -6.1307 | 1.7805 | 0.0036 | 0.0057 | 6.1787 |
| Imatinib | MDA-MB-175-VII | -3.2480 | 0.9700 | -4.8320 | -4.8324 | -5.2006 | 1.4170 | 0.0000 | 0.0057 | 5.9697 |
| Afatinib | SUM159PT | -4.1759 | 0.9287 | -5.5719 | -5.5719 | -5.6128 | 1.5990 | 0.0000 | 0.0058 | 6.2405 |
| CGC-11144 | MCF 10A | -3.1500 | 0.9374 | -5.7900 | -5.7897 | -5.8851 | 0.8967 | 0.0000 | 0.0058 | 5.0079 |
| Sunitinib | AU565 | -3.7773 | 0.9773 | -5.3158 | -5.3157 | -5.4531 | 1.4640 | 0.0000 | 0.0058 | 6.2895 |
| Fascaplysin | 184B5 | -4.4776 | 0.9939 | -6.4566 | -6.4549 | -6.5644 | 3.4105 | 0.0058 | 0.0058 | 5.6477 |
| Cisplatin | MCF 10F | -3.6021 | 0.9342 | -5.2451 | -5.2453 | -5.4373 | 1.3630 | 0.0000 | 0.0058 | 6.3583 |
| Z-Leu-Leu-Norvalinal | HCC1937 | -4.1759 | 0.9971 | -6.0099 | -6.0088 | -6.3789 | 3.9990 | 0.0058 | 0.0058 | 5.9138 |
| Vorinostat | SK-BR-3 | -1.7282 | 0.9388 | -4.2237 | -4.2216 | -4.4272 | 1.4870 | 0.0053 | 0.0058 | 4.6385 |
| Sunitinib | HCC1569 | -3.7773 | 0.9785 | -5.0693 | -5.0677 | -5.1025 | 3.5100 | 0.0059 | 0.0059 | 6.7454 |
| Imatinib | CAMA-1 | -3.2480 | 0.9889 | -4.5860 | -4.5847 | -4.7328 | 3.1970 | 0.0056 | 0.0059 | 6.5864 |
| CGC-11144 | Hs 578T | -3.1500 | 0.9195 | -4.7950 | -4.7948 | -4.9516 | 1.6600 | 0.0000 | 0.0059 | 5.9958 |
| MG-132 | SUM149PT | -4.1759 | 0.9905 | -6.8064 | -6.8046 | -6.8545 | 3.7055 | 0.0059 | 0.0059 | 4.6941 |
| Sunitinib | SUM52PE | -3.7773 | 0.9788 | -5.6913 | -5.6909 | -5.9821 | 1.1640 | 0.0000 | 0.0059 | 5.4960 |