Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK461364 | LY2 | -4.4776 | 0.7525 | -5.3501 | -5.3501 | -5.9259 | 0.3841 | 0.0000 | 0.3161 | 6.7154 |
| GSK461364 | HCC1428 | -4.4776 | 0.9592 | -4.9400 | -4.9399 | -5.2690 | 3.3400 | 0.0000 | 0.0203 | 7.7381 |
| Tozasertib | SUM225CWN | -4.0000 | 0.8959 | -4.5514 | -4.5514 | -4.7894 | 2.4360 | 0.0000 | 0.0434 | 7.4471 |
| Tozasertib | SUM1315MO2 | -4.0000 | 0.9491 | -4.7150 | -4.7149 | -5.4637 | 0.8303 | 0.0000 | 0.2031 | 7.2828 |
| Tozasertib | MDA-MB-231 | -4.0000 | 0.9221 | -4.8628 | -4.8630 | -4.9264 | 1.1070 | 0.0000 | 0.0998 | 7.3371 |
| GSK461364 | HCC1569 | -4.4776 | 0.7965 | -5.0714 | -5.0714 | -5.7745 | 0.3696 | 0.0000 | 0.3763 | 6.5207 |
| Tozasertib | BT-20 | -4.0000 | 0.8366 | -4.6124 | -4.6124 | -5.5324 | 0.4999 | 0.0000 | 0.3307 | 7.0328 |
| Tozasertib | BT-474 | -4.0000 | 0.8143 | -4.4178 | -4.4177 | -5.1819 | 1.5550 | 0.0000 | 0.1831 | 7.9621 |
| GSK461364 | T47D | -4.4776 | 0.7866 | -4.9834 | -4.9834 | -6.1129 | 1.8790 | 0.0000 | 0.1008 | 7.2108 |
| Tozasertib | BT-549 | -4.0000 | 0.9135 | -5.5800 | -5.5799 | -5.7199 | 0.6894 | 0.0000 | 0.0753 | 6.3599 |
| GSK461364 | UACC-812 | -4.4776 | 0.8943 | -4.8642 | -4.8641 | -5.0359 | 3.7120 | 0.0000 | 0.0354 | 8.8806 |
| Imatinib | MCF7 | -3.2480 | 0.9699 | -4.5890 | -4.5889 | -4.7959 | 2.0400 | 0.0000 | 0.0019 | 6.5013 |
| Tozasertib | HCC1395 | -4.0000 | 0.9267 | -4.9570 | -4.9570 | -5.7943 | 0.9915 | 0.0000 | 0.1011 | 6.6654 |
| Tozasertib | HCC1419 | -4.0000 | 0.8498 | -4.1981 | -4.1981 | -4.8568 | 0.9298 | 0.0000 | 0.3956 | 7.7843 |
| Tozasertib | MDA-MB-134-VI | -4.0000 | 0.9695 | -4.7252 | -4.7252 | -5.7263 | 0.4520 | 0.0000 | 0.3198 | 7.0698 |
| Tozasertib | HCC1569 | -4.0000 | 0.9023 | -5.0220 | -5.0220 | -5.7245 | 0.5522 | 0.0000 | 0.2143 | 6.7476 |
| GSK461364 | 184B5 | -4.4776 | 0.7303 | -5.5881 | -5.5882 | -6.3658 | 0.4307 | 0.0000 | 0.2496 | 6.7499 |
| Tozasertib | MDA-MB-157 | -4.0000 | 0.9065 | -5.0270 | -5.0273 | -5.4475 | 0.8482 | 0.0000 | 0.1185 | 6.9191 |
| Tozasertib | MDA-MB-361 | -4.0000 | 0.9415 | -4.5904 | -4.5905 | -5.2826 | 2.2145 | 0.0000 | 0.0505 | 7.4753 |
| Tozasertib | MDA-MB-175-VII | -4.0000 | 0.9576 | -4.4982 | -4.4983 | -4.8063 | 3.0030 | 0.0000 | 0.0309 | 7.5216 |
| Tozasertib | HCC38 | -4.0000 | 0.9362 | -6.0550 | -6.0552 | -6.5583 | 0.5106 | 0.0000 | 0.0819 | 5.5362 |
| Tozasertib | HCC70 | -4.0000 | 0.7843 | -5.2470 | -5.2466 | NaN | 0.3821 | 0.0000 | 0.2503 | 6.3077 |
| GSK461364 | MCF 10F | -4.4776 | 0.8285 | -6.0156 | -6.0160 | -7.2051 | 0.4255 | 0.0000 | 0.2392 | 6.1498 |
| PD173074 | MDA-MB-436 | -4.4776 | 0.9492 | -5.0428 | -5.0428 | -5.1998 | 1.5480 | 0.0000 | 0.1177 | 7.5471 |
| PD173074 | MDA-MB-361 | -4.4776 | 0.9419 | -4.7887 | -4.7887 | -4.6550 | 3.3020 | 0.0000 | 0.0858 | 8.3236 |