Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Topotecan | BT-549 | -3.9626 | 0.9871 | -7.6526 | -7.6260 | -7.7001 | 2.6710 | 0.0748 | 0.0748 | 3.5874 |
| GSK461364 | MDA-MB-157 | -4.4776 | 0.9444 | -9.0436 | -8.9391 | -9.0610 | 2.6360 | 0.2340 | 0.2340 | 3.5893 |
| CGC-11144 | SUM52PE | -3.1500 | 0.9702 | -6.6460 | -6.6393 | -6.8275 | 2.7340 | 0.0144 | 0.0144 | 3.5998 |
| Vinorelbine | MDA-MB-361 | -4.3335 | 0.9103 | -7.8875 | -7.8287 | -7.9808 | 2.8390 | 0.1590 | 0.1590 | 3.6134 |
| Taxol | HCC1806 | -4.4776 | 0.9897 | -8.0876 | -8.0685 | -8.1579 | 2.7400 | 0.0655 | 0.0655 | 3.6186 |
| Torkinib | HCC1954 | -4.3010 | 0.9756 | -8.3140 | -8.0526 | -8.9641 | 0.3341 | 0.0911 | 0.1308 | 3.6259 |
| Geldanamycin | MCF12A | -4.0000 | 0.9897 | -7.6935 | -7.6765 | -7.7504 | 3.2375 | 0.0600 | 0.0600 | 3.6298 |
| Bortezomib | 184B5 | -3.7773 | 0.9844 | -7.5418 | -7.4975 | -7.7046 | 2.0090 | 0.0924 | 0.0924 | 3.6326 |
| Bortezomib | HCC38 | -3.7773 | 0.9900 | -7.1958 | -7.1957 | -7.2796 | 3.4400 | 0.0004 | 0.0004 | 3.6395 |
| Taxol | MDA-MB-468 | -4.4776 | 0.9946 | -8.1086 | -8.0920 | -8.1719 | 3.9990 | 0.0721 | 0.0721 | 3.6461 |
| Ixabepilone | SUM149PT | -4.4045 | 0.9637 | -8.2275 | -8.1536 | -8.3009 | 1.3730 | 0.1035 | 0.1035 | 3.6488 |
| Torkinib | MDA-MB-157 | -4.3010 | 0.9776 | -7.6960 | -7.6959 | -7.9967 | 0.3909 | 0.0000 | 0.0450 | 3.6514 |
| Docetaxel | SUM159PT | -5.0000 | 0.9753 | -8.7915 | -8.7477 | -8.8094 | 2.1380 | 0.0956 | 0.0956 | 3.6627 |
| Bortezomib | HCC1143 | -3.7773 | 0.9884 | -7.3523 | -7.3420 | -7.4207 | 3.6360 | 0.0400 | 0.0400 | 3.6639 |
| CGC-11144 | SUM159PT | -3.1500 | 0.9615 | -6.6100 | -6.5933 | -6.6719 | 0.9747 | 0.0181 | 0.0185 | 3.6906 |
| Torkinib | ZR-75-1 | -4.3010 | 0.9479 | -9.8430 | -8.9499 | -10.7280 | 0.5030 | 0.3223 | 0.3234 | 3.6921 |
| Gemcitabine | AU565 | -3.8416 | 0.9938 | -7.7556 | -7.6986 | -7.8877 | 2.5020 | 0.1406 | 0.1406 | 3.7074 |
| CGC-11144 | HCC3153 | -3.1500 | 0.9913 | -6.6440 | -6.6419 | -6.7766 | 3.9840 | 0.0111 | 0.0111 | 3.7081 |
| Torkinib | T47D | -4.3010 | 0.9460 | -9.4110 | -8.5983 | -9.5701 | 0.4377 | 0.2796 | 0.2838 | 3.7359 |
| Torkinib | HCC1569 | -4.3010 | 0.9797 | -7.8180 | -7.8177 | -9.0248 | 0.2628 | 0.0000 | 0.1064 | 3.7403 |
| CGC-11144 | HCC70 | -3.1500 | 0.9768 | -6.3890 | -6.3820 | -6.5904 | 1.9810 | 0.0151 | 0.0151 | 3.7473 |
| Bortezomib | MDA-MB-134-VI | -3.7773 | 0.9930 | -7.0923 | -7.0895 | -7.3434 | 2.5220 | 0.0079 | 0.0079 | 3.7604 |
| Epirubicin | MCF12A | -3.7645 | 0.9770 | -7.0825 | -7.0822 | -7.3078 | 0.8421 | 0.0000 | 0.0016 | 3.7649 |
| Taxol | MDA-MB-231 | -4.4776 | 0.9683 | -8.2826 | -8.2094 | -8.3050 | 1.4965 | 0.1313 | 0.1313 | 3.7711 |
| CGC-11144 | T47DKBLUC | -3.1500 | 0.9913 | -6.4130 | -6.4110 | -6.5411 | 3.5590 | 0.0094 | 0.0094 | 3.7715 |