Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Valproic acid | BT-474 | -1.8239 | 0.9366 | -2.5820 | -2.5821 | -3.1409 | 1.3030 | 0.0000 | 0.1051 | 7.1024 |
| Valproic acid | BT-20 | -1.8239 | 0.8160 | -2.3127 | -2.0752 | -2.4689 | 3.2920 | 0.2469 | 0.2785 | 7.8380 |
| Valproic acid | AU565 | -1.8239 | 0.9633 | -2.7437 | -2.7436 | -2.8960 | 1.9410 | 0.0000 | 0.0161 | 7.1314 |
| Valproic acid | MDA-MB-231 | -1.8239 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 9.0492 |
| Valproic acid | SK-BR-3 | -1.8239 | 0.9461 | -2.8599 | -2.8600 | -3.1183 | 1.3620 | 0.0000 | 0.0373 | 6.5826 |
| Valproic acid | MCF7 | -1.8239 | 0.9500 | -2.2909 | -2.2348 | -2.6402 | 1.7280 | 0.1000 | 0.2214 | 7.9772 |
| Valproic acid | T47D | -1.8239 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 7.1259 |
| 5-DFUR | AU565 | -2.3010 | 0.8667 | -5.3030 | -4.3049 | -5.2191 | 0.5622 | 0.3626 | 0.3754 | 6.0160 |
| 5-DFUR | MDA-MB-231 | -2.3010 | 0.8760 | -3.4730 | -3.3613 | -3.4799 | 1.2300 | 0.1355 | 0.1657 | 7.6494 |
| 5-DFUR | BT-20 | -2.3010 | 0.8072 | -2.8957 | -2.4068 | -3.5554 | 0.5198 | 0.2009 | 0.4854 | 7.5241 |
| 5-DFUR | MCF7 | -2.3010 | 0.8187 | -3.6250 | -2.3010 | -3.8407 | 1.0180 | 0.5231 | 0.5436 | 7.6867 |
| 5-DFUR | SK-BR-3 | -2.3010 | 0.8096 | -2.5574 | -2.5574 | NaN | 0.2672 | 0.0000 | 0.4606 | 6.9216 |
| 5-DFUR | BT-474 | -2.3010 | 0.8103 | -2.0940 | -2.3010 | -3.3351 | 0.3593 | 0.0000 | 0.5427 | 8.0229 |
| Trichostatin A | HCC70 | -2.3010 | 0.9937 | -4.6980 | -4.6943 | -4.8885 | 2.4470 | 0.0104 | 0.0104 | 5.1089 |
| Trichostatin A | Hs 578T | -2.3010 | 0.9769 | -4.7195 | -4.7134 | -4.7692 | 2.8145 | 0.0120 | 0.0120 | 5.2163 |
| 5-DFUR | BT-483 | -2.3010 | 0.8857 | -1.9972 | -2.3010 | -4.0420 | 0.3377 | 0.0000 | 0.5556 | 7.6481 |
| Trichostatin A | MB 157 | -2.3010 | 0.9928 | -4.9680 | -4.9666 | -5.0738 | 1.7480 | 0.0032 | 0.0032 | 4.5977 |
| Trichostatin A | MDA-MB-134-VI | -2.3010 | 0.9556 | -4.9020 | -4.8003 | -5.2452 | 1.8090 | 0.1660 | 0.1664 | 5.4139 |
| Trichostatin A | HCC1954 | -2.3010 | 0.9200 | -4.8680 | -4.8614 | -5.0142 | 1.9125 | 0.0223 | 0.0223 | 4.5927 |
| CGC-11047 | BT-483 | -2.3010 | 0.8210 | -2.7831 | -2.4601 | -3.2758 | 1.5504 | 0.2775 | 0.4450 | 8.1875 |
| Trichostatin A | HCC202 | -2.3010 | 0.9946 | -5.6060 | -5.6001 | -5.9612 | 2.1550 | 0.0149 | 0.0149 | 3.7975 |
| Trichostatin A | HCC1569 | -2.3010 | 0.8717 | -4.9980 | -4.9721 | -5.0569 | 2.2065 | 0.0585 | 0.0585 | 4.6730 |
| Trichostatin A | HCC1806 | -2.3010 | 0.9690 | -4.9315 | -4.9267 | -5.0104 | 2.1805 | 0.0119 | 0.0119 | 4.6628 |
| 5-DFUR | BT-549 | -2.3010 | 0.9520 | -3.6210 | -3.4398 | -3.6133 | 0.7796 | 0.1390 | 0.2126 | 6.7109 |
| Trichostatin A | HCC1937 | -2.3010 | 0.9829 | -4.6870 | -4.6441 | -4.8525 | 1.4350 | 0.0659 | 0.0663 | 5.3981 |