Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Pevonedistat | MB 157 | -4.1759 | 0.9932 | -6.7019 | -6.4660 | -6.6475 | 1.6180 | 0.2922 | 0.2923 | 6.0738 |
| Pevonedistat | MDA-MB-134-VI | -4.1759 | 0.9722 | -6.8759 | -6.2974 | -7.0851 | 0.9557 | 0.3555 | 0.3562 | 6.2532 |
| Pevonedistat | MDA-MB-157 | -4.1759 | 0.9626 | -7.0049 | -6.6396 | -7.2785 | 0.7059 | 0.2237 | 0.2314 | 5.4395 |
| Pevonedistat | MDA-MB-175-VII | -4.1759 | 0.9419 | -6.1859 | -4.1759 | -6.6452 | 1.0870 | 0.5014 | 0.5032 | 7.1397 |
| Pevonedistat | MDA-MB-361 | -4.1759 | 0.9797 | -6.6829 | -6.4560 | -7.0414 | 2.0880 | 0.3780 | 0.3780 | 6.3496 |
| Pevonedistat | MDA-MB-436 | -4.1759 | 0.9905 | -6.3359 | -6.2581 | -6.5564 | 1.5860 | 0.1239 | 0.1242 | 5.9399 |
| Pevonedistat | MDA-MB-453 | -4.1759 | 0.9288 | -5.8419 | -5.0771 | -5.8712 | 1.0330 | 0.4189 | 0.4297 | 7.3220 |
| Pevonedistat | MDA-MB-468 | -4.1759 | 0.9564 | -6.6929 | -6.5800 | -6.7359 | 1.4170 | 0.1544 | 0.1546 | 5.5537 |
| Pevonedistat | T47D | -4.1759 | 0.9010 | -6.9669 | -4.1759 | -6.8717 | 4.0000 | 0.5162 | 0.5162 | 6.6893 |
| Pevonedistat | UACC-812 | -4.1759 | 0.7789 | -5.8749 | -4.5921 | -6.0415 | 1.0200 | 0.2893 | 0.4631 | 7.0326 |
| Pevonedistat | UACC-893 | -4.1759 | 0.8891 | -6.4369 | -5.2805 | -7.4679 | 0.4618 | 0.3538 | 0.4073 | 6.4661 |
| Pevonedistat | ZR-75-1 | -4.1759 | 0.8384 | -6.2919 | -4.1759 | -6.1022 | 0.3620 | 0.5399 | 0.6072 | 7.4843 |
| Pevonedistat | 184B5 | -4.1759 | 0.9599 | -6.6889 | -6.4338 | -6.9618 | 0.6333 | 0.1553 | 0.1764 | 5.5504 |
| Pevonedistat | HCC1187 | -4.1759 | 0.9317 | -6.1224 | -5.7694 | -6.1661 | 1.7605 | 0.3732 | 0.3736 | 6.7800 |
| Pevonedistat | MCF 10A | -4.1759 | 0.9257 | -6.3929 | -6.1576 | -6.3757 | 0.6034 | 0.1395 | 0.1773 | 5.8169 |
| Pevonedistat | MCF 10F | -4.1759 | 0.9841 | -6.2629 | -5.7249 | -6.2501 | 0.8432 | 0.3242 | 0.3357 | 6.6091 |
| Pevonedistat | SUM1315MO2 | -4.1759 | 0.9830 | -6.8989 | -6.1629 | -7.1890 | 0.8167 | 0.3748 | 0.3785 | 7.1280 |
| Pevonedistat | SUM149PT | -4.1759 | 0.9793 | -6.6034 | -6.5713 | -6.7753 | 0.9462 | 0.0323 | 0.0375 | 5.0716 |
| Pevonedistat | SUM159PT | -4.1759 | 0.9366 | -6.3599 | -6.2900 | -6.3416 | 1.3570 | 0.0927 | 0.0947 | 5.8072 |
| Pevonedistat | SUM185PE | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 5.7833 |
| Pevonedistat | SUM225CWN | -4.1759 | 0.7742 | -5.0094 | -4.7867 | -5.3435 | 1.0175 | 0.2028 | 0.3034 | 7.6015 |
| Pevonedistat | SUM229PE | -4.1759 | 0.9482 | -6.6829 | -6.4861 | -6.6610 | 1.5720 | 0.2545 | 0.2546 | 5.8549 |
| Pevonedistat | SUM52PE | -4.1759 | 0.8933 | -6.2029 | -5.8257 | -6.5426 | 1.2574 | 0.2258 | 0.3036 | 6.3634 |
| Pevonedistat | 184A1 | -4.1759 | 0.9401 | -6.2569 | -5.4225 | -6.2842 | 0.7104 | 0.3722 | 0.3924 | 6.8653 |
| Pevonedistat | MCF12A | -4.1759 | 0.9837 | -7.0024 | -6.6975 | -7.0920 | 0.8586 | 0.2204 | 0.2236 | 5.3896 |