Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | Abemaciclib | CDK4/6 | Cell cycle | 0.044561 | -0.3272 | 0.6404 | 0.0910 | 0.4303 | 0.21535 | 0.96385 |
| MDA-MB-361 | Abemaciclib | CDK4/6 | Cell cycle | 0.0053492 | -0.3418 | 0.8279 | 0.0335 | 0.5371 | 0.0096902 | 0.8686 |
| T47D | Abemaciclib | CDK4/6 | Cell cycle | 0.0042816 | -0.0412 | 0.7664 | 0.0265 | 1.3858 | 0.0037683 | 0.95899 |
| BT-549 | Abemaciclib | CDK4/6 | Cell cycle | 3.9707 | 0.0333 | 0.1267 | 0.0188 | 1.2825 | 7.5655 | 0.99654 |
| PDX1328 | Abemaciclib | CDK4/6 | Cell cycle | 0.0036552 | -0.7514 | 0.8680 | 0.0940 | 0.2489 | 0.30192 | 0.79917 |
| MDA-MB-453 | Abemaciclib | CDK4/6 | Cell cycle | 0.0057723 | -0.7647 | 0.8495 | 0.1526 | 0.2725 | 0.32512 | 0.73985 |
| HCC1395 | Abemaciclib | CDK4/6 | Cell cycle | 0.11228 | -0.5202 | 0.5623 | 0.0665 | 0.3941 | 1.8243 | 0.93379 |
| SK-BR-3 | Abemaciclib | CDK4/6 | Cell cycle | 0.035311 | 0.1432 | 0.5363 | 0.0387 | 0.6381 | 0.016543 | 0.96857 |
| SUM149PT | Abemaciclib | CDK4/6 | Cell cycle | 0.6361 | 0.0949 | 0.3411 | 0.0126 | 0.4432 | 1.358 | 0.96302 |
| MDA-MB-157 | Abemaciclib | CDK4/6 | Cell cycle | 1.7983 | -0.6042 | 0.2687 | 0.0667 | 1.1925 | 4.518 | 0.93286 |
| PDXHCI002 | Abemaciclib | CDK4/6 | Cell cycle | 0.047944 | -0.6767 | 0.7662 | 0.1664 | 0.6873 | 0.18848 | 0.98885 |
| MDA-MB-231 | Abemaciclib | CDK4/6 | Cell cycle | 0.046803 | -0.4875 | 0.6754 | 0.1393 | 0.3863 | 0.73058 | 0.97904 |
| HCC1143 | Abemaciclib | CDK4/6 | Cell cycle | 0.07025 | -0.0787 | 0.5407 | 0.0153 | 0.5300 | 0.09592 | 0.97963 |
| CAL-85-1 | Abemaciclib | CDK4/6 | Cell cycle | 1.3003 | -0.2236 | 0.2357 | 0.0485 | 2.1239 | 1.5776 | 0.99317 |
| Hs 578T | Abemaciclib | CDK4/6 | Cell cycle | 0.077629 | -0.5825 | 0.6343 | 0.1966 | 0.4160 | 1.0889 | 0.95772 |
| MCF 10A | Abemaciclib | CDK4/6 | Cell cycle | 0.34027 | 0.1513 | 0.3811 | -0.0012 | 0.5714 | 0.28176 | 0.99756 |
| MDA-MB-468 | Abemaciclib | CDK4/6 | Cell cycle | 2.3386 | -0.2881 | 0.1766 | 0.0681 | 1.5630 | 3.8065 | 0.9935 |
| MDA-MB-436 | Abemaciclib | CDK4/6 | Cell cycle | 2.1015 | -0.3331 | 0.1897 | 0.0464 | 1.1593 | 5.3251 | 0.99054 |
| HCC1806 | Abemaciclib | CDK4/6 | Cell cycle | 0.59453 | -0.4440 | 0.3921 | 0.1035 | 0.6190 | 3.5069 | 0.96621 |
| CAMA-1 | Abemaciclib | CDK4/6 | Cell cycle | 0.007859 | 0.2222 | 0.6130 | -0.0040 | 1.3608 | 0.0046978 | 0.97968 |
| MDA-MB-231 | ABT-737 | Bcl2/XL | Misc | 3.031 | -0.1204 | 0.1616 | 0.0795 | 1.1097 | 8.1572 | 0.99586 |
| BT-549 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9359 | -0.0225 | 0.0062 | 0.0000 | Inf | 0.067883 |
| HCC1954 | ABT-737 | Bcl2/XL | Misc | 9.9512 | 0.4962 | 0.0404 | 0.0618 | 1.0240 | 27.9634 | 0.94601 |
| MDA-MB-436 | ABT-737 | Bcl2/XL | Misc | 26.1321 | 0.8154 | 0.0064 | 0.0038 | 1.3541 | 40.6846 | 0.74833 |
| HCC1806 | ABT-737 | Bcl2/XL | Misc | 12.0843 | 0.7293 | -0.0285 | 0.0138 | 5.0000 | 12.4641 | 0.7932 |