Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | A-1210477 | Mcl-1 | Misc | Inf | 0.8758 | 0.0026 | 0.0051 | 0.0000 | Inf | 0.45696 |
| HCC1937 | A-1210477 | Mcl-1 | Misc | Inf | 0.7240 | 0.0060 | 0.0046 | 4.0529 | 5.9209 | 0.95858 |
| BT-549 | A-1210477 | Mcl-1 | Misc | Inf | 0.9540 | 0.0083 | 0.0018 | 0.0000 | Inf | 0.34182 |
| PDX1328 | A-1210477 | Mcl-1 | Misc | 29.0724 | 0.7094 | 0.0609 | 0.0135 | 0.6451 | 128.4233 | 0.82503 |
| HCC38 | A-1210477 | Mcl-1 | Misc | 14.9391 | 0.8870 | 0.0151 | 0.0032 | 4.9989 | 15.3353 | 0.65537 |
| MDA-MB-468 | A-1210477 | Mcl-1 | Misc | Inf | 0.9299 | 0.0206 | 0.0057 | 0.3898 | 963.6809 | 0.60314 |
| HCC1419 | A-1210477 | Mcl-1 | Misc | 14.536 | 0.7081 | 0.0402 | 0.0018 | 1.8053 | 26.3399 | 0.8672 |
| HCC1806 | A-1210477 | Mcl-1 | Misc | Inf | 0.9047 | -0.0078 | 0.0015 | 4.2962 | 12.7646 | 0.58471 |
| SK-BR-3 | A-1210477 | Mcl-1 | Misc | 11.3859 | 0.6275 | 0.0389 | 0.0040 | 4.3303 | 10.9082 | 0.92796 |
| MCF 10A | A-1210477 | Mcl-1 | Misc | Inf | 0.9527 | 0.0018 | 0.0006 | 4.5125 | 3.8181 | 0.94609 |
| SK-BR-3 | Abemaciclib | CDK4/6 | Cell cycle | 0.035311 | 0.1432 | 0.5363 | 0.0387 | 0.6381 | 0.016543 | 0.96857 |
| HCC70 | Abemaciclib | CDK4/6 | Cell cycle | 1.885 | -0.8264 | 0.2315 | 0.0832 | 2.5102 | 2.8439 | 0.99569 |
| HCC1954 | Abemaciclib | CDK4/6 | Cell cycle | 0.30182 | -0.5049 | 0.4578 | 0.0869 | 0.4867 | 2.8851 | 0.937 |
| PDX1328 | Abemaciclib | CDK4/6 | Cell cycle | 0.0036552 | -0.7514 | 0.8680 | 0.0940 | 0.2489 | 0.30192 | 0.79917 |
| MCF 10A | Abemaciclib | CDK4/6 | Cell cycle | 0.34027 | 0.1513 | 0.3811 | -0.0012 | 0.5714 | 0.28176 | 0.99756 |
| CAL-120 | Abemaciclib | CDK4/6 | Cell cycle | 0.247 | -0.1408 | 0.4780 | 0.0849 | 0.3730 | 4.696 | 0.95026 |
| HCC1500 | Abemaciclib | CDK4/6 | Cell cycle | 0.53346 | 0.2196 | 0.3452 | -0.0085 | 0.4860 | 0.1477 | 0.84102 |
| MDA-MB-436 | Abemaciclib | CDK4/6 | Cell cycle | 2.1015 | -0.3331 | 0.1897 | 0.0464 | 1.1593 | 5.3251 | 0.99054 |
| HCC1937 | Abemaciclib | CDK4/6 | Cell cycle | 4.8534 | 0.3020 | 0.1062 | 0.0050 | 0.9638 | 6.1622 | 0.98334 |
| MDA-MB-157 | Abemaciclib | CDK4/6 | Cell cycle | 1.7983 | -0.6042 | 0.2687 | 0.0667 | 1.1925 | 4.518 | 0.93286 |
| HCC1395 | Abemaciclib | CDK4/6 | Cell cycle | 0.11228 | -0.5202 | 0.5623 | 0.0665 | 0.3941 | 1.8243 | 0.93379 |
| BT-549 | Abemaciclib | CDK4/6 | Cell cycle | 3.9707 | 0.0333 | 0.1267 | 0.0188 | 1.2825 | 7.5655 | 0.99654 |
| HCC38 | Abemaciclib | CDK4/6 | Cell cycle | 0.044561 | -0.3272 | 0.6404 | 0.0910 | 0.4303 | 0.21535 | 0.96385 |
| MCF7 | Abemaciclib | CDK4/6 | Cell cycle | 0.023572 | -0.2684 | 0.7018 | 0.0913 | 0.3795 | 0.13917 | 0.95433 |
| CAL-51 | Abemaciclib | CDK4/6 | Cell cycle | 0.11268 | -0.4637 | 0.5776 | 0.0890 | 0.4136 | 1.605 | 0.97536 |