Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| PDX1328 | TGX221 | PI3Kb | PI3K/mTOR | 22.8162 | 0.7594 | 0.0116 | 0.0024 | 1.1153 | 60.9221 | 0.6986 |
| MDA-MB-231 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8508 | 0.0154 | 0.0050 | 0.6946 | 20.4646 | 0.68698 |
| CAMA-1 | TGX221 | PI3Kb | PI3K/mTOR | 42.7345 | 0.8500 | 0.0067 | 0.0034 | 0.9968 | 118.889 | 0.79474 |
| HCC1500 | TGX221 | PI3Kb | PI3K/mTOR | 10.1303 | 0.5035 | 0.0860 | 0.0066 | 0.8370 | 24.4491 | 0.82467 |
| MDA-MB-134-VI | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8589 | -0.0381 | -0.0029 | 0.0000 | Inf | 0.38211 |
| MCF7 | TGX221 | PI3Kb | PI3K/mTOR | 15.3151 | 0.7893 | -0.0068 | 0.0019 | 3.9246 | 12.6094 | 0.85557 |
| MDA-MB-453 | TGX221 | PI3Kb | PI3K/mTOR | 15.3342 | 0.8281 | -0.0281 | 0.0177 | 4.9457 | 12.4514 | 0.62788 |
| HCC1428 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7695 | 0.0143 | 0.0033 | 4.9999 | 3.7973 | 0.75865 |
| HCC1419 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7941 | -0.0049 | 0.0002 | 5.0000 | 3.889 | 0.79312 |
| MDA-MB-157 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8240 | 0.0006 | 0.0043 | 1.2013 | 6.2128 | 0.76213 |
| MCF 10A | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9505 | 0.0050 | 0.0003 | 0.8181 | 270.4333 | 0.86411 |
| HME1 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0265 | -0.0318 | -0.0005 | 0.0000 | Inf | -0.12868 |
| HCC1395 | TGX221 | PI3Kb | PI3K/mTOR | 8.4625 | 0.4581 | 0.0950 | 0.0125 | 0.6815 | 16.0341 | 0.94431 |
| MDA-MB-361 | TGX221 | PI3Kb | PI3K/mTOR | 13.225 | 0.7989 | -0.0336 | 0.0006 | 4.9995 | 13.1104 | 0.64936 |
| Hs 578T | TGX221 | PI3Kb | PI3K/mTOR | 34.4921 | 0.7094 | 0.0668 | 0.0103 | 0.5623 | 243.351 | 0.9333 |
| SUM1315MO2 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7054 | 0.1362 | 0.0073 | 0.9367 | 0.077385 | 0.83645 |
| CAL-51 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9105 | -0.0094 | 0.0003 | 0.0000 | Inf | 0.56048 |
| MDA-MB-436 | TGX221 | PI3Kb | PI3K/mTOR | 22.0461 | 0.7221 | 0.0019 | 0.0048 | 1.3022 | 18.6589 | 0.84405 |
| HCC1806 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9819 | -0.0154 | 0.0035 | 0.0000 | Inf | -0.19348 |
| HCC1143 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9185 | 0.0347 | 0.0040 | 4.9981 | 0.020639 | 0.76284 |
| CAL-120 | Volasertib | PLK | Cell cycle | 0.0018536 | 0.0258 | 0.6758 | 0.2649 | 2.5191 | 0.001844 | 0.99276 |
| HME1 | Volasertib | PLK | Cell cycle | 0.017242 | -0.0817 | 0.4263 | 0.1273 | 3.6204 | 0.017483 | 0.99425 |
| HCC1428 | Volasertib | PLK | Cell cycle | 0.018634 | -0.0388 | 0.4063 | 0.0917 | 2.1456 | 0.018507 | 0.99276 |
| HCC38 | Volasertib | PLK | Cell cycle | 0.0081934 | -0.2598 | 0.6001 | 0.1943 | 3.2088 | 0.0091367 | 0.99678 |
| HCC1500 | Volasertib | PLK | Cell cycle | 0.011592 | 0.2861 | 0.3454 | 0.0484 | 5.0000 | 0.0099361 | 0.97732 |