Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9911 | -0.0383 | -0.0001 | 0.0000 | Inf | -2.9826 |
| MDA-MB-436 | Ipatasertib | AKT | PI3K/mTOR | 25.8679 | 0.6111 | 0.1038 | 0.0116 | 0.4073 | 383.9431 | 0.92516 |
| PDX1328 | Ipatasertib | AKT | PI3K/mTOR | 4.7978 | 0.3012 | 0.1323 | 0.0153 | 0.6377 | 26.7942 | 0.95509 |
| HCC1806 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9450 | 0.0145 | -0.0020 | 0.0000 | Inf | 0.32254 |
| BT-549 | Ipatasertib | AKT | PI3K/mTOR | 12.6362 | 0.4956 | 0.1735 | 0.0097 | 0.5079 | 1.6786 | 0.97652 |
| MDA-MB-453 | Ipatasertib | AKT | PI3K/mTOR | 0.53911 | -0.1551 | 0.3144 | 0.0753 | 1.3090 | 0.65666 | 0.98992 |
| MDA-MB-361 | Ipatasertib | AKT | PI3K/mTOR | 0.31325 | -0.5798 | 0.4548 | 0.0905 | 0.7404 | 1.2042 | 0.98932 |
| HCC70 | Ipatasertib | AKT | PI3K/mTOR | 0.1397 | -0.2624 | 0.4974 | 0.0860 | 0.8534 | 0.21677 | 0.98567 |
| MDA-MB-231 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9254 | 0.0073 | -0.0008 | 0.0000 | Inf | 0.28623 |
| HCC38 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.7055 | 0.1225 | 0.0092 | 1.1410 | 0.22841 | 0.9721 |
| HCC1806 | Ceritinib | ALK | RTK | 2.1149 | -0.4060 | 0.1766 | 0.0793 | 2.2387 | 2.8712 | 0.99364 |
| HCC1937 | Ceritinib | ALK | RTK | 3.5257 | -0.5730 | 0.1368 | 0.0730 | 2.2956 | 5.6897 | 0.99584 |
| MDA-MB-361 | Ceritinib | ALK | RTK | 0.26636 | -0.9910 | 0.5462 | 0.1443 | 0.8263 | 1.0067 | 0.97236 |
| BT-20 | Ceritinib | ALK | RTK | 1.5315 | -0.7365 | 0.2591 | 0.1255 | 1.7439 | 2.7905 | 0.99717 |
| HCC1500 | Ceritinib | ALK | RTK | 1.4068 | -0.9535 | 0.2988 | 0.1206 | 1.5745 | 2.8266 | 0.97255 |
| HCC1419 | Ceritinib | ALK | RTK | 2.6149 | -0.8670 | 0.2083 | 0.0855 | 2.5745 | 4.0066 | 0.99248 |
| BT-549 | Ceritinib | ALK | RTK | 2.961 | -0.2284 | 0.1416 | 0.0526 | 1.8781 | 4.216 | 0.99556 |
| PDX1258 | Ceritinib | ALK | RTK | 2.081 | -0.6841 | 0.2165 | 0.0876 | 1.5671 | 4.1949 | 0.9759 |
| HCC1954 | Ceritinib | ALK | RTK | 2.3105 | -0.4446 | 0.1668 | 0.0701 | 2.4217 | 3.1138 | 0.99363 |
| MCF 10A | Ceritinib | ALK | RTK | 2.9867 | -0.3186 | 0.1843 | 0.0521 | 1.3962 | 6.5603 | 0.98775 |
| MDA-MB-157 | Ceritinib | ALK | RTK | 0.48405 | -0.9264 | 0.4600 | 0.1138 | 0.9467 | 1.5449 | 0.97503 |
| CAL-51 | Ceritinib | ALK | RTK | 0.47536 | -0.4763 | 0.4172 | 0.1229 | 1.1654 | 0.88025 | 0.99344 |
| Hs 578T | Ceritinib | ALK | RTK | 0.96543 | -0.4356 | 0.3052 | 0.1254 | 0.8330 | 3.6097 | 0.98175 |
| MCF7 | Ceritinib | ALK | RTK | 0.34376 | -0.6157 | 0.4566 | 0.1487 | 0.9502 | 0.88109 | 0.9932 |
| SK-BR-3 | Ceritinib | ALK | RTK | 0.98319 | -0.8254 | 0.3174 | 0.0975 | 1.2454 | 2.3754 | 0.98337 |