Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-134-VI Doxorubicin
Chemo
Chemotherapy
0.0033105
 -0.9458 1.1481 0.2491 0.9132
0.010163
0.97259
HCC1937 Taxol
Chemo
Chemotherapy
0.0024514
 0.0104 0.6576 0.2104 2.2541
0.0024561
0.99541
MDA-MB-468 Cisplatin
Chemo
Chemotherapy
1.2638
 -0.2866 0.2872 0.0977 1.4057
1.9559
0.99503
CAL-120 Taxol
Chemo
Chemotherapy
0.0028769
 -0.1987 0.7463 0.3104 2.6390
0.0032354
0.97877
MDA-MB-468 Taxol
Chemo
Chemotherapy
0.001354
 -0.5218 1.0076 0.5243 1.2795
0.0023644
0.95471
PDX1258 Etoposide
Topo II
Chemotherapy
0.31701
 -0.1807 0.3942 0.1360 1.0906
0.41876
0.99346
PDX1258 Topotecan
Topo I
Chemotherapy
0.013472
 -0.4565 0.8673 0.2817 0.8122
0.026852
0.98013
MDA-MB-436 Etoposide
Topo II
Chemotherapy
0.26013
 -0.1571 0.4348 0.0454 0.9014
0.38084
0.99169
HCC1500 Cisplatin
Chemo
Chemotherapy
3.4531
 0.2076 0.1210 -0.0094 5.0000
3.1071
0.92762
MDA-MB-436 Doxorubicin
Chemo
Chemotherapy
0.0076138
 -0.1288 0.7061 0.0611 1.3442
0.0088093
0.99253
MDA-MB-436 Cisplatin
Chemo
Chemotherapy
0.4173
 -0.0204 0.3606 0.0365 1.2366
0.44452
0.99287
MDA-MB-436 Taxol
Chemo
Chemotherapy
0.0037097
 -0.2183 0.7083 0.1530 3.2043
0.0040962
0.99739
PDX1258 Taxol
Chemo
Chemotherapy
0.0021522
 -0.0818 0.6797 0.2357 1.2501
0.0022935
0.98829
MDA-MB-436 Topotecan
Topo I
Chemotherapy
0.0059389
 -0.1398 0.8768 0.0855 1.0160
0.0074925
0.99666
HCC1500 Doxorubicin
Chemo
Chemotherapy
0.016258
 -0.7134 0.7518 0.1833 0.7212
0.058468
0.98572
HCC1419 Doxorubicin
Chemo
Chemotherapy
0.025082
 -0.4663 0.5904 0.0473 0.5199
0.10425
0.94593
HCC1419 Taxol
Chemo
Chemotherapy
0.0052608
 0.2143 0.4700 0.0981 2.1841
0.0040283
0.97754
BT-549 Cisplatin
Chemo
Chemotherapy
1.016
 0.0674 0.2835 0.0552 1.0827
1.0937
0.98489
BT-549 Doxorubicin
Chemo
Chemotherapy
0.006482
 -0.3312 0.7603 0.1972 1.5744
0.0079126
0.9824
BT-549 Taxol
Chemo
Chemotherapy
0.0027257
 -0.2074 0.6989 0.2304 1.9420
0.0030953
0.98743
BT-549 Topotecan
Topo I
Chemotherapy
0.0084727
 -0.2410 0.8509 0.2269 1.4734
0.010061
0.9801
HCC1806 Etoposide
Topo II
Chemotherapy
0.096233
 -0.5629 0.6490 0.2019 0.9767
0.2057
0.99535
SK-BR-3 Etoposide
Topo II
Chemotherapy
0.39826
 -0.3169 0.4040 0.1186 1.5701
0.532
0.99524
PDX1258 Cisplatin
Chemo
Chemotherapy
2.5568
 0.3181 0.1555 0.0433 1.6027
1.5449
0.99079
HCC1419 Topotecan
Topo I
Chemotherapy
0.0071886
 -0.7857 0.9904 0.1711 0.4002
0.11192
0.94532