Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SUM1315MO2 Abemaciclib
CDK4/6
Cell cycle
0.049304
 -0.1445 0.5815 0.0291 0.5067
0.075697
0.94514
MDA-MB-436 Dinaciclib
pan CDK
Cell cycle
0.014324
 -0.1440 0.4903 0.0235 4.8527
0.014993
0.99777
SK-BR-3 Alpelisib
PI3Ka
PI3K/mTOR
0.48468
 -0.1428 0.3788 0.0660 0.4911
2.8836
0.98115
HCC1395 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.014555
 -0.1424 0.4547 0.0604 1.6344
0.015746
0.98865
CAL-120 Abemaciclib
CDK4/6
Cell cycle
0.247
 -0.1408 0.4780 0.0849 0.3730
4.696
0.95026
HCC1806 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.03581
 -0.1402 0.3877 0.1005 0.9893
0.048229
0.99141
HCC1954 Vorinostat
HDAC
Misc
1.426
 -0.1401 0.2339 0.0833 1.2390
2.0871
0.99732
MDA-MB-436 Topotecan
Topo I
Chemotherapy
0.0059389
 -0.1398 0.8768 0.0855 1.0160
0.0074925
0.99666
PDX1258 INK-128
mTORC1/2
PI3K/mTOR
0.044023
 -0.1381 0.4558 0.0805 1.5509
0.046987
0.98841
PDXHCI002 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.6002
 -0.1369 0.3740 0.0320 0.4025
9.1998
0.95462
Hs 578T Etoposide
Topo II
Chemotherapy
0.41322
 -0.1361 0.3770 0.1666 2.0332
0.46109
0.99901
BT-549 Cediranib
VEGFR/cKIT
RTK
3.6412
 -0.1347 0.1497 0.0414 1.3011
8.4712
0.98092
CAL-51 Bleomycin
Radiation
Misc
0.1694
 -0.1344 0.4855 0.0479 0.8490
0.24736
0.9994
PDX1258 Dasatinib
BCR/ABL
MAPK/nRTK
0.021598
 -0.1339 0.7143 0.0924 1.3176
0.024774
0.99367
T47D Taxol
Chemo
Chemotherapy
0.0035285
 -0.1337 0.6636 0.2505 2.2353
0.0038792
0.99665
MCF7 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0045641
 -0.1330 0.6027 0.1279 0.9398
0.0052657
0.98973
HCC1806 Volasertib
PLK
Cell cycle
0.0027998
 -0.1323 0.7262 0.2950 5.0000
0.0029495
0.99776
CAL-120 Dinaciclib
pan CDK
Cell cycle
0.009892
 -0.1320 0.5549 0.1203 4.4157
0.010404
0.99947
HCC1500 Pictilisib
pan PI3K
PI3K/mTOR
2.3061
 -0.1317 0.2108 0.0313 0.8635
8.2307
0.96692
HCC1143 Pictilisib
pan PI3K
PI3K/mTOR
0.97831
 -0.1291 0.3201 0.0583 0.5213
8.0489
0.97859
MDA-MB-436 Doxorubicin
Chemo
Chemotherapy
0.0076138
 -0.1288 0.7061 0.0611 1.3442
0.0088093
0.99253
BT-20 Bleomycin
Radiation
Misc
0.4878
 -0.1286 0.3764 0.0970 0.9564
0.75174
0.99474
SK-BR-3 Pictilisib
pan PI3K
PI3K/mTOR
0.11448
 -0.1267 0.5120 0.0731 0.6701
0.17544
0.99532
MCF 10A Taxol
Chemo
Chemotherapy
0.0026843
 -0.1256 0.7023 0.2576 1.8234
0.003018
0.9967
MDA-MB-231 Dasatinib
BCR/ABL
MAPK/nRTK
0.02942
 -0.1256 0.6475 0.1153 0.6812
0.03753
0.98521