Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1395 Doxorubicin
Chemo
Chemotherapy
0.01793
 -0.4166 0.6370 0.1543 1.1158
0.025315
0.96347
MDA-MB-468 Dinaciclib
pan CDK
Cell cycle
0.015576
 -0.4131 0.5681 0.1843 2.8840
0.018635
0.99641
MDA-MB-157 Vorinostat
HDAC
Misc
1.0981
 -0.4130 0.2980 0.0489 1.0997
2.487
0.9968
CAL-51 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.13353
 -0.4129 0.5460 0.1721 0.4106
1.9394
0.97937
HCC38 Doxorubicin
Chemo
Chemotherapy
0.0095452
 -0.4061 0.7803 0.2872 1.4810
0.01343
0.99228
HCC1806 Ceritinib
ALK
RTK
2.1149
 -0.4060 0.1766 0.0793 2.2387
2.8712
0.99364
HCC1419 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0091784
 -0.4046 0.8523 0.0945 0.5809
0.022714
0.98223
HCC38 Ceritinib
ALK
RTK
1.8283
 -0.4039 0.2184 0.0883 2.6153
2.323
0.99573
HCC1395 Bleomycin
Radiation
Misc
0.10419
 -0.4023 0.6070 0.1775 0.6889
0.30452
0.9971
HCC1954 Topotecan
Topo I
Chemotherapy
0.011912
 -0.4011 0.8695 0.3601 0.7510
0.02452
0.96722
HME1 Doxorubicin
Chemo
Chemotherapy
0.0047147
 -0.3985 0.8359 0.2785 0.9521
0.0078037
0.96003
HCC1954 AZD7762
CHK1/2
Cell cycle
0.12298
 -0.3978 0.5593 0.2944 1.4965
0.1737
0.98591
HCC1954 Taxol
Chemo
Chemotherapy
0.0024667
 -0.3961 0.8347 0.4142 1.6514
0.0034177
0.98666
PDX1258 Buparlisib
pan PI3K
PI3K/mTOR
1.3631
 -0.3924 0.2516 0.0862 1.2064
2.8058
0.99443
SUM149PT Luminespib
HSP90
Misc
0.005116
 -0.3912 0.7555 0.3563 2.6742
0.0063272
0.99952
CAL-51 Buparlisib
pan PI3K
PI3K/mTOR
0.9892
 -0.3883 0.3283 0.1186 1.5630
1.5215
0.99245
SUM1315MO2 Volasertib
PLK
Cell cycle
0.0095
 -0.3877 0.6658 0.2263 2.3240
0.012143
0.99552
MDA-MB-231 Vorinostat
HDAC
Misc
1.2388
 -0.3848 0.2821 0.1116 1.7685
1.7699
0.99365
HCC1954 Tivantinib
MET
RTK
0.16715
 -0.3846 0.5511 0.2533 1.4818
0.24265
0.99675
HME1 Etoposide
Topo II
Chemotherapy
0.13797
 -0.3838 0.5421 0.1754 1.3297
0.19469
0.98888
CAL-85-1 Luminespib
HSP90
Misc
0.006517
 -0.3836 0.7497 0.3002 4.8089
0.0073269
0.99963
BT-20 Etoposide
Topo II
Chemotherapy
0.30148
 -0.3834 0.4591 0.1362 1.2176
0.48057
0.99643
MDA-MB-468 Neratinib
EGFR/HER2
RTK
0.15781
 -0.3825 0.3861 0.1513 0.8303
0.41607
0.99579
MDA-MB-436 Cediranib
VEGFR/cKIT
RTK
3.6098
 -0.3824 0.1610 0.0446 1.8229
6.595
0.98039
SUM159PT Ceritinib
ALK
RTK
1.5606
 -0.3800 0.2590 0.1427 2.5153
1.9758
0.99862