Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SK-BR-3 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0061659
 -0.2068 0.8068 0.1477 0.6730
0.0081626
0.97463
PDX1258 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.99608
 0.1062 0.2777 0.0362 0.6747
1.3027
0.98871
PDXHCI002 Saracatinib
SRC
MAPK/nRTK
0.080448
 0.0015 0.5120 0.0185 0.6754
0.078329
0.98663
BT-20 Neratinib
EGFR/HER2
RTK
1.2826
 0.3026 0.1496 0.0391 0.6768
2.19
0.97744
MDA-MB-157 Alpelisib
PI3Ka
PI3K/mTOR
9.7515
 0.4924 0.1041 0.0114 0.6775
11.4208
0.96993
MDA-MB-361 Alpelisib
PI3Ka
PI3K/mTOR
0.22264
 -0.7994 0.5323 0.1181 0.6802
1.1196
0.97671
CAL-51 Saracatinib
SRC
MAPK/nRTK
1.8499
 0.2582 0.2271 0.0547 0.6810
1.6055
0.99804
MDA-MB-231 Dasatinib
BCR/ABL
MAPK/nRTK
0.02942
 -0.1256 0.6475 0.1153 0.6812
0.03753
0.98521
HCC1395 TGX221
PI3Kb
PI3K/mTOR
8.4625
 0.4581 0.0950 0.0125 0.6815
16.0341
0.94431
MDA-MB-134-VI Etoposide
Topo II
Chemotherapy
0.086844
 -0.5248 0.6635 0.0687 0.6849
0.28885
0.9792
MDA-MB-436 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.041679
 0.1227 0.3390 0.0305 0.6859
0.029409
0.97813
PDXHCI002 Abemaciclib
CDK4/6
Cell cycle
0.047944
 -0.6767 0.7662 0.1664 0.6873
0.18848
0.98885
HCC1395 Bleomycin
Radiation
Misc
0.10419
 -0.4023 0.6070 0.1775 0.6889
0.30452
0.9971
HCC38 Trametinib
MEK
MAPK/nRTK
0.22023
 0.1854 0.2076 0.0234 0.6910
0.35783
0.98881
SUM149PT INK-128
mTORC1/2
PI3K/mTOR
0.16131
 0.2613 0.3199 0.0092 0.6928
0.056936
0.98747
T47D Saracatinib
SRC
MAPK/nRTK
3.9647
 0.3892 0.1722 0.0087 0.6928
1.6318
0.9752
HCC1395 Taselisib
PI3Ka, g, d
PI3K/mTOR
2.1401
 -0.0177 0.2078 0.0314 0.6939
10.4247
0.98026
MDA-MB-231 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.8508 0.0154 0.0050 0.6946
20.4646
0.68698
MDA-MB-468 Taselisib
PI3Ka, g, d
PI3K/mTOR
2.3526
 0.0046 0.2170 0.0736 0.6960
11.4039
0.97997
T47D Pictilisib
pan PI3K
PI3K/mTOR
0.15529
 -0.1470 0.4772 0.0336 0.7031
0.2394
0.99267
HCC1143 INK-128
mTORC1/2
PI3K/mTOR
0.04046
 0.0314 0.4743 0.0660 0.7035
0.039906
0.9903
HCC38 Neratinib
EGFR/HER2
RTK
3.1556
 0.4571 0.1019 0.0168 0.7043
15.0154
0.87632
HCC70 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.15092
 -0.6846 0.5796 0.1546 0.7043
0.64661
0.98584
PDXHCI002 Alpelisib
PI3Ka
PI3K/mTOR
30.4631
 0.6296 0.0630 -0.0034 0.7047
10.7379
0.92415
SUM1315MO2 Saracatinib
SRC
MAPK/nRTK
1.3921
 0.0846 0.2439 0.0407 0.7066
2.4563
0.99551