Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-436 Ipatasertib
AKT
PI3K/mTOR
25.8679
 0.6111 0.1038 0.0116 0.4073
383.9431
0.92516
MDA-MB-361 Olaparib
PARP
Misc
4.8624
 0.0945 0.1038 0.0095 1.2844
11.0203
0.97233
MDA-MB-157 Alpelisib
PI3Ka
PI3K/mTOR
9.7515
 0.4924 0.1041 0.0114 0.6775
11.4208
0.96993
HCC1428 Neratinib
EGFR/HER2
RTK
1.4327
 -0.0412 0.1042 0.0283 1.5482
2.7752
0.9933
MDA-MB-231 Neratinib
EGFR/HER2
RTK
1.4329
 -0.0957 0.1056 0.0516 1.6284
2.8124
0.99527
HCC1937 Abemaciclib
CDK4/6
Cell cycle
4.8534
 0.3020 0.1062 0.0050 0.9638
6.1622
0.98334
MCF7 Cabozantinib
VEGFR2/MET
RTK
4.8819
 -0.0993 0.1069 0.0302 1.8080
8.9638
0.99698
HCC1419 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.5051 0.1071 0.0007 1.4251
0.82031
0.95841
HCC1806 Trametinib
MEK
MAPK/nRTK
Inf
 0.7036 0.1086 0.0280 4.8006
0.007609
0.89189
CAMA-1 Cediranib
VEGFR/cKIT
RTK
5.0236
 -0.2923 0.1089 0.0448 2.4671
7.8416
0.99299
SUM1315MO2 Cabozantinib
VEGFR2/MET
RTK
4.5316
 0.1095 0.1089 0.0163 1.1058
12.2361
0.99069
HCC1419 PF-4708671
p70S6K
PI3K/mTOR
5.2795
 0.3488 0.1117 -0.0019 1.0898
4.6502
0.97858
HME1 Alpelisib
PI3Ka
PI3K/mTOR
6.0356
 0.3071 0.1123 0.0079 0.9018
20.4027
0.98253
MCF 10A Alpelisib
PI3Ka
PI3K/mTOR
17.193
 0.5787 0.1126 -0.0029 0.4411
201.6709
0.99492
MCF 10A Everolimus
mTOR1
PI3K/mTOR
Inf
 0.7889 0.1130 0.0000 0.4668
0.070049
0.96385
HCC1395 Vorinostat
HDAC
Misc
3.2812
 -0.0589 0.1137 0.0365 2.1496
3.8175
0.99171
SUM159PT Ipatasertib
AKT
PI3K/mTOR
9.2403
 0.4884 0.1149 0.0020 0.9180
2.8242
0.99791
SUM159PT Cisplatin
Chemo
Chemotherapy
5.2539
 0.1742 0.1149 0.0416 1.1412
13.758
0.99717
MDA-MB-157 Olaparib
PARP
Misc
5.3864
 0.1575 0.1149 0.0097 1.2271
13.1864
0.97814
MDA-MB-231 Cediranib
VEGFR/cKIT
RTK
5.0964
 -0.3620 0.1160 0.0659 2.7537
7.595
0.99835
CAL-51 Olaparib
PARP
Misc
7.1917
 0.3596 0.1163 0.0073 0.8214
27.3972
0.94373
MDA-MB-157 Cisplatin
Chemo
Chemotherapy
5.2381
 0.1885 0.1168 0.0072 1.3335
8.7509
0.97923
SUM1315MO2 Alpelisib
PI3Ka
PI3K/mTOR
6.462
 0.3829 0.1169 0.0203 0.5997
40.3568
0.94056
HCC1428 Pictilisib
pan PI3K
PI3K/mTOR
5.8689
 0.1916 0.1171 0.0310 1.2411
14.2229
0.90007
MDA-MB-468 PF-4708671
p70S6K
PI3K/mTOR
4.1732
 0.0813 0.1176 0.0094 1.1782
8.8804
0.99743