Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1806 Dinaciclib
pan CDK
Cell cycle
0.013395
 -0.4585 0.6439 0.3114 3.4710
0.016174
0.99891
PDX1258 Topotecan
Topo I
Chemotherapy
0.013472
 -0.4565 0.8673 0.2817 0.8122
0.026852
0.98013
HCC1500 Dinaciclib
pan CDK
Cell cycle
0.013792
 -0.5720 0.6616 0.1978 2.3762
0.018927
0.99749
HCC1954 INK-128
mTORC1/2
PI3K/mTOR
0.014251
 -0.0830 0.5651 0.1455 1.3479
0.013876
0.98856
MDA-MB-436 Dinaciclib
pan CDK
Cell cycle
0.014324
 -0.1440 0.4903 0.0235 4.8527
0.014993
0.99777
SUM159PT Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.014492
 0.1057 0.4137 0.0050 1.4641
0.011782
0.9977
HCC1395 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.014555
 -0.1424 0.4547 0.0604 1.6344
0.015746
0.98865
CAMA-1 Dinaciclib
pan CDK
Cell cycle
0.014558
 -0.4849 0.6062 0.1927 2.0283
0.019954
0.99839
CAL-51 Dinaciclib
pan CDK
Cell cycle
0.014709
 -0.3585 0.5985 0.2374 3.5319
0.017105
0.99939
PDX1258 AZD7762
CHK1/2
Cell cycle
0.014946
 -0.4528 0.9199 0.3234 1.6838
0.021221
0.99249
CAL-51 INK-128
mTORC1/2
PI3K/mTOR
0.014971
 0.0529 0.5532 0.1010 0.9663
0.012822
0.99761
SUM1315MO2 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.015037
 -0.0903 0.4863 0.0621 0.7079
0.022637
0.99665
Hs 578T AZD7762
CHK1/2
Cell cycle
0.015096
 -0.5983 0.8646 0.4133 1.8783
0.01967
0.95944
HCC1143 Dinaciclib
pan CDK
Cell cycle
0.015148
 -0.2527 0.5451 0.1106 5.0000
0.016398
0.9989
MDA-MB-157 AZD7762
CHK1/2
Cell cycle
0.015418
 -0.7858 0.9840 0.3122 0.8223
0.045445
0.98837
HCC1937 Topotecan
Topo I
Chemotherapy
0.0155
 -0.4282 0.8369 0.2949 0.6712
0.03544
0.94323
MDA-MB-468 Dinaciclib
pan CDK
Cell cycle
0.015576
 -0.4131 0.5681 0.1843 2.8840
0.018635
0.99641
CAL-85-1 Topotecan
Topo I
Chemotherapy
0.015768
 -0.2957 0.8426 0.2732 1.2311
0.02233
0.99293
MDA-MB-468 Topotecan
Topo I
Chemotherapy
0.015779
 -0.6577 1.0692 0.4464 2.1036
0.023029
0.99528
HCC1806 Doxorubicin
Chemo
Chemotherapy
0.015898
 -0.3241 0.6281 0.1971 1.0948
0.021206
0.97525
MDA-MB-468 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.016032
 -0.0415 0.4371 0.1010 0.9482
0.015849
0.98843
MCF7 Doxorubicin
Chemo
Chemotherapy
0.016105
 -0.2856 0.6363 0.1012 0.9326
0.024539
0.97476
MCF 10A Dinaciclib
pan CDK
Cell cycle
0.016244
 -0.2300 0.5279 0.2344 5.0000
0.017523
0.99904
HCC1500 Doxorubicin
Chemo
Chemotherapy
0.016258
 -0.7134 0.7518 0.1833 0.7212
0.058468
0.98572
SK-BR-3 Topotecan
Topo I
Chemotherapy
0.016549
 -0.2711 0.7941 0.1919 1.9350
0.01923
0.98214