Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAL-120 Taxol
Chemo
Chemotherapy
0.0028769
 -0.1987 0.7463 0.3104 2.6390
0.0032354
0.97877
PDX1328 Volasertib
PLK
Cell cycle
0.0025124
 -0.5731 0.9694 0.2182 2.8453
0.0032751
0.99856
PDX1328 Luminespib
HSP90
Misc
0.0023764
 -0.4697 0.8697 0.1444 1.9222
0.0032941
0.9864
CAL-85-1 Taxol
Chemo
Chemotherapy
0.0027273
 -0.3464 0.7931 0.3351 2.0210
0.0033785
0.95638
MDA-MB-231 Trametinib
MEK
MAPK/nRTK
0.0026306
 -0.1785 0.7224 0.2816 1.1618
0.0033911
0.99829
HCC1954 Taxol
Chemo
Chemotherapy
0.0024667
 -0.3961 0.8347 0.4142 1.6514
0.0034177
0.98666
Hs 578T Luminespib
HSP90
Misc
0.0032976
 -0.1144 0.6699 0.2289 2.5765
0.0035402
0.99828
Hs 578T Trametinib
MEK
MAPK/nRTK
0.0063584
 0.1931 0.4907 0.0713 0.9022
0.0036513
0.99154
PDX1328 Taxol
Chemo
Chemotherapy
0.002983
 -0.5332 0.9047 0.1888 3.1886
0.0036802
0.98401
HME1 Taxol
Chemo
Chemotherapy
0.0031675
 -0.2241 0.6794 0.2401 1.5314
0.0037399
0.98563
T47D Abemaciclib
CDK4/6
Cell cycle
0.0042816
 -0.0412 0.7664 0.0265 1.3858
0.0037683
0.95899
HCC1395 Volasertib
PLK
Cell cycle
0.0032085
 -0.2962 0.7641 0.1714 2.7096
0.00378
0.99662
HCC1419 Neratinib
EGFR/HER2
RTK
0.0011485
 -0.5015 0.9927 0.1818 0.5367
0.0038194
0.97246
T47D Taxol
Chemo
Chemotherapy
0.0035285
 -0.1337 0.6636 0.2505 2.2353
0.0038792
0.99665
HCC1500 Taxol
Chemo
Chemotherapy
0.0038131
 -0.0589 0.6182 0.1433 1.8138
0.0038924
0.96247
CAL-85-1 Volasertib
PLK
Cell cycle
0.0032652
 -0.2891 0.7316 0.1652 2.0442
0.0039314
0.99429
MDA-MB-436 Luminespib
HSP90
Misc
0.0039107
 -0.0492 0.6326 0.0393 3.6046
0.004027
0.999
HCC1419 Taxol
Chemo
Chemotherapy
0.0052608
 0.2143 0.4700 0.0981 2.1841
0.0040283
0.97754
MDA-MB-361 Volasertib
PLK
Cell cycle
0.0035439
 -0.4972 0.8204 0.1921 4.6311
0.0040451
0.98886
MDA-MB-436 Taxol
Chemo
Chemotherapy
0.0037097
 -0.2183 0.7083 0.1530 3.2043
0.0040962
0.99739
MDA-MB-361 Taxol
Chemo
Chemotherapy
0.0031082
 -0.6090 0.9738 0.2561 2.5508
0.0042111
0.9201
MDA-MB-157 Luminespib
HSP90
Misc
0.0041789
 -0.0490 0.6146 0.0676 4.3520
0.004258
0.99849
MDA-MB-453 Luminespib
HSP90
Misc
0.0032643
 -0.4995 0.8803 0.2734 2.6468
0.0042685
0.99671
PDXHCI002 Volasertib
PLK
Cell cycle
0.0037003
 -0.5892 0.8480 0.3925 4.6276
0.0042869
0.99531
HCC1143 Luminespib
HSP90
Misc
0.0039434
 -0.1922 0.7017 0.1659 3.6671
0.0042921
0.99512