Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SK-BR-3 Tivantinib
MET
RTK
0.27263
 -0.3523 0.4830 0.2060 2.4177
0.34098
0.99571
MCF7 Buparlisib
pan PI3K
PI3K/mTOR
0.18746
 -0.2690 0.5035 0.1162 0.8936
0.34198
0.99189
Hs 578T Ipatasertib
AKT
PI3K/mTOR
4.5924
 0.4423 0.2458 0.0093 0.5006
0.34659
0.98155
HCC1143 Tivantinib
MET
RTK
0.27789
 -0.3122 0.4977 0.1369 1.9433
0.35725
0.99341
HCC38 Trametinib
MEK
MAPK/nRTK
0.22023
 0.1854 0.2076 0.0234 0.6910
0.35783
0.98881
BT-549 Trametinib
MEK
MAPK/nRTK
5.2409
 0.5983 0.1292 0.0152 0.5005
0.36186
0.97942
HCC1937 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.5349 0.1565 0.0058 1.0014
0.36202
0.97156
CAMA-1 Tivantinib
MET
RTK
0.27573
 -0.5655 0.5259 0.2061 2.2178
0.36921
0.99228
MDA-MB-468 Tivantinib
MET
RTK
0.30706
 -0.4549 0.4903 0.2341 2.9835
0.37002
0.99499
T47D Tivantinib
MET
RTK
0.3478
 -0.1544 0.3824 0.1267 3.7033
0.37139
0.99567
CAL-120 Tivantinib
MET
RTK
0.25132
 -0.2562 0.4649 0.1572 1.1267
0.37355
0.99876
Hs 578T Bleomycin
Radiation
Misc
0.25197
 -0.1966 0.4462 0.2094 0.9580
0.37819
0.99872
MDA-MB-436 Etoposide
Topo II
Chemotherapy
0.26013
 -0.1571 0.4348 0.0454 0.9014
0.38084
0.99169
SUM159PT Bleomycin
Radiation
Misc
0.28119
 -0.0577 0.4191 0.1680 0.7700
0.38984
0.99881
HCC38 Tivantinib
MET
RTK
0.30919
 -0.2702 0.4367 0.1297 1.8013
0.39141
0.99767
HCC1419 Tivantinib
MET
RTK
0.47955
 0.1634 0.2618 0.0408 2.6512
0.40663
0.98985
SUM159PT Palbociclib
CDK4/6
Cell cycle
1.1058
 0.3876 0.1990 -0.0006 0.6326
0.40763
0.99661
MDA-MB-468 Neratinib
EGFR/HER2
RTK
0.15781
 -0.3825 0.3861 0.1513 0.8303
0.41607
0.99579
MDA-MB-453 Etoposide
Topo II
Chemotherapy
0.38265
 -0.0601 0.3658 0.0418 1.5864
0.41689
0.99692
PDX1258 Etoposide
Topo II
Chemotherapy
0.31701
 -0.1807 0.3942 0.1360 1.0906
0.41876
0.99346
HCC70 Etoposide
Topo II
Chemotherapy
0.36498
 -0.1518 0.4535 0.0513 2.1004
0.41879
0.96872
Hs 578T Tivantinib
MET
RTK
0.33668
 -0.3204 0.4411 0.2071 2.0560
0.42597
0.99878
MDA-MB-231 Tivantinib
MET
RTK
0.41694
 -0.0845 0.3330 0.1029 2.2640
0.43275
0.99134
MDA-MB-134-VI Ceritinib
ALK
RTK
0.13159
 -0.9992 0.6654 0.1723 0.9173
0.43587
0.98922
MDA-MB-436 Tivantinib
MET
RTK
0.3675
 -0.2711 0.4215 0.0897 2.2220
0.44342
0.99833