Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

 Full screen view
Filter results: >>>>
Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1937 Olaparib
PARP
Misc
26.5474
 0.6855 0.0584 0.0092 0.6339
150.1948
0.9681
SUM149PT INK-128
mTORC1/2
PI3K/mTOR
0.16131
 0.2613 0.3199 0.0092 0.6928
0.056936
0.98747
HCC38 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.7055 0.1225 0.0092 1.1410
0.22841
0.9721
HCC38 Alpelisib
PI3Ka
PI3K/mTOR
22.4126
 0.6801 0.0440 0.0092 0.7155
102.9667
0.92013
Hs 578T Ipatasertib
AKT
PI3K/mTOR
4.5924
 0.4423 0.2458 0.0093 0.5006
0.34659
0.98155
MDA-MB-361 ABT-737
Bcl2/XL
Misc
Inf
 0.8441 -0.0067 0.0094 2.5452
4.5021
0.68512
MDA-MB-468 PF-4708671
p70S6K
PI3K/mTOR
4.1732
 0.0813 0.1176 0.0094 1.1782
8.8804
0.99743
MDA-MB-361 Olaparib
PARP
Misc
4.8624
 0.0945 0.1038 0.0095 1.2844
11.0203
0.97233
HCC1954 Olaparib
PARP
Misc
11.1008
 0.5266 0.0536 0.0095 1.2000
8.359
0.96291
MDA-MB-231 Etoposide
Topo II
Chemotherapy
0.7036
 0.1203 0.2978 0.0095 1.5558
0.62323
0.99162
BT-549 Cabozantinib
VEGFR2/MET
RTK
10.1855
 0.5329 0.0124 0.0096 5.0000
12.5665
0.95054
MDA-MB-134-VI Ipatasertib
AKT
PI3K/mTOR
8.0392
 0.4925 0.0150 0.0096 4.9968
3.7717
0.94642
HCC1428 Cisplatin
Chemo
Chemotherapy
0.91164
 0.1223 0.2655 0.0096 1.2004
0.80529
0.9803
MDA-MB-157 Olaparib
PARP
Misc
5.3864
 0.1575 0.1149 0.0097 1.2271
13.1864
0.97814
BT-549 Ipatasertib
AKT
PI3K/mTOR
12.6362
 0.4956 0.1735 0.0097 0.5079
1.6786
0.97652
MDA-MB-436 Dasatinib
BCR/ABL
MAPK/nRTK
Inf
 0.6528 0.1022 0.0098 0.0000
Inf
0.40773
SUM149PT Everolimus
mTOR1
PI3K/mTOR
Inf
 0.7389 0.2003 0.0098 0.2094
0.00021362
0.67353
SUM1315MO2 Ipatasertib
AKT
PI3K/mTOR
36.6304
 0.6070 0.1242 0.0099 0.3263
999.2697
0.9146
BT-549 Alpelisib
PI3Ka
PI3K/mTOR
17.5141
 0.6841 0.0322 0.0099 1.0429
49.8384
0.95639
MDA-MB-231 Palbociclib
CDK4/6
Cell cycle
0.11065
 0.2066 0.3469 0.0101 0.7428
0.05699
0.98815
Hs 578T Olaparib
PARP
Misc
8.9082
 0.4435 0.0997 0.0101 1.0369
25.6993
0.93656
BT-20 PF-4708671
p70S6K
PI3K/mTOR
15.1446
 0.6601 0.0129 0.0102 1.1942
37.9666
0.89476
SK-BR-3 Saracatinib
SRC
MAPK/nRTK
4.9166
 0.2786 0.0221 0.0102 5.0000
4.2128
0.96696
Hs 578T TGX221
PI3Kb
PI3K/mTOR
34.4921
 0.7094 0.0668 0.0103 0.5623
243.351
0.9333
MDA-MB-134-VI Bleomycin
Radiation
Misc
1.7911
 0.0193 0.2734 0.0108 0.5040
15.841
0.87961