Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1500 Cabozantinib
VEGFR2/MET
RTK
4.6683
 0.1837 0.0599 0.0128 4.9992
4.2912
0.97044
MDA-MB-436 Taselisib
PI3Ka, g, d
PI3K/mTOR
4.6563
 0.2431 0.1736 0.0143 0.6355
26.2348
0.92245
SUM149PT Ipatasertib
AKT
PI3K/mTOR
4.6451
 0.2929 0.1261 0.0067 0.9023
6.7816
0.99801
Hs 578T Ipatasertib
AKT
PI3K/mTOR
4.5924
 0.4423 0.2458 0.0093 0.5006
0.34659
0.98155
HCC70 Cediranib
VEGFR/cKIT
RTK
4.5386
 -0.3262 0.0890 0.0440 2.2440
7.4053
0.99062
SUM1315MO2 Cabozantinib
VEGFR2/MET
RTK
4.5316
 0.1095 0.1089 0.0163 1.1058
12.2361
0.99069
HCC70 Alpelisib
PI3Ka
PI3K/mTOR
4.4987
 0.0981 0.1182 0.0196 1.0448
12.8744
0.95143
HCC1419 Bleomycin
Radiation
Misc
4.4662
 0.3545 0.1588 -0.0001 0.8100
4.0786
0.85928
MDA-MB-468 Dasatinib
BCR/ABL
MAPK/nRTK
4.4311
 0.3393 0.1447 0.0458 0.7091
5.6436
0.97277
PDX1258 Ipatasertib
AKT
PI3K/mTOR
4.4024
 0.3985 0.1556 0.0120 0.7553
1.2185
0.94717
SUM159PT Alpelisib
PI3Ka
PI3K/mTOR
4.3125
 0.2818 0.1409 0.0003 0.7761
8.5413
0.99788
MCF 10A Cisplatin
Chemo
Chemotherapy
4.2937
 0.3794 0.0952 0.0149 2.1287
2.4561
0.99519
MDA-MB-453 PF-4708671
p70S6K
PI3K/mTOR
4.291
 0.0482 0.0418 0.0294 4.9998
4.2285
0.98022
CAMA-1 TGX221
PI3Kb
PI3K/mTOR
42.7345
 0.8500 0.0067 0.0034 0.9968
118.889
0.79474
HCC1428 Bleomycin
Radiation
Misc
4.2581
 0.2173 0.1780 0.0166 0.7393
18.8191
0.91689
HCC1428 Taselisib
PI3Ka, g, d
PI3K/mTOR
4.2249
 0.1734 0.1438 0.0192 0.8693
14.9521
0.96527
MDA-MB-134-VI Cediranib
VEGFR/cKIT
RTK
4.2103
 -0.9999 0.0977 0.0979 5.0000
5.2449
0.99321
MDA-MB-468 PF-4708671
p70S6K
PI3K/mTOR
4.1732
 0.0813 0.1176 0.0094 1.1782
8.8804
0.99743
T47D Cediranib
VEGFR/cKIT
RTK
4.1027
 -0.6403 0.1246 0.0754 2.9281
5.9706
0.99504
HCC1954 Cediranib
VEGFR/cKIT
RTK
4.092
 -0.3202 0.0756 0.0534 4.9589
4.5507
0.99308
HCC1428 ABT-737
Bcl2/XL
Misc
4.0616
 0.2431 0.1194 0.0716 1.0222
5.0858
0.98165
Hs 578T Saracatinib
SRC
MAPK/nRTK
4.0375
 0.1890 0.1594 0.0291 0.7110
18.9291
0.97543
PDX1328 Bleomycin
Radiation
Misc
4.0022
 0.3061 0.1994 0.0033 0.4524
45.3783
0.95786
BT-549 Abemaciclib
CDK4/6
Cell cycle
3.9707
 0.0333 0.1267 0.0188 1.2825
7.5655
0.99654
T47D Saracatinib
SRC
MAPK/nRTK
3.9647
 0.3892 0.1722 0.0087 0.6928
1.6318
0.9752