LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 69.71 | 13.4 | 3.1094 | 3.0871 | 0.0108 | 0.0168 | 5.0000 | 0.1075 |
| MCF 10A-H2B-mCherry | Alpelisib | 69.71 | 13.4 | Inf | Inf | 0.8659 | 0.8659 | 0.0000 | 0.0193 |
| MCF 10A-H2B-mCherry | Etoposide | 69.71 | 13.4 | 0.5077 | 0.5252 | -0.1330 | -0.0302 | 3.4199 | 0.3350 |
| MCF 10A-H2B-mCherry | Neratinib | 69.71 | 13.4 | 0.5895 | 0.6414 | -0.3513 | -0.2624 | 5.0000 | 0.2420 |
| MCF 10A-H2B-mCherry | Dasatinib | 69.71 | 13.4 | 2.5863 | 2.9033 | -0.3708 | -0.3922 | 5.0000 | 0.2048 |
| MCF 10A-H2B-mCherry | Palbociclib | 69.71 | 13.4 | 3.1977 | 5.394 | -0.0186 | -0.4657 | 1.2682 | 0.1393 |
| MCF 10A-H2B-mCherry | Trametinib | 69.71 | 13.4 | 0.0283 | 0.0275 | -0.0156 | 0.0459 | 4.2625 | 0.3921 |
| MCF 10A-H2B-mCherry | Taxol | 69.71 | 13.4 | 0.0023 | 0.0025 | -0.2735 | -0.1573 | 4.8802 | 0.6351 |
| MCF 10A-H2B-mCherry | Etoposide | 71.94 | 13.4 | 0.541 | 0.5582 | -0.0714 | -0.0338 | 3.5133 | 0.3384 |
| MCF 10A-H2B-mCherry | Vorinostat | 71.94 | 13.4 | 3.2871 | 3.3126 | -0.0160 | -0.0202 | 5.0000 | 0.0996 |
| MCF 10A-H2B-mCherry | Dasatinib | 71.94 | 13.4 | 2.6626 | 3.0476 | -0.4700 | -0.4838 | 5.0000 | 0.1943 |
| MCF 10A-H2B-mCherry | Trametinib | 71.94 | 13.4 | 0.0301 | 0.0295 | -0.0284 | 0.0490 | 5.0000 | 0.3826 |
| MCF 10A-H2B-mCherry | Alpelisib | 71.94 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0105 |
| MCF 10A-H2B-mCherry | Palbociclib | 71.94 | 13.4 | 2.7362 | 2.5853 | 0.0380 | 0.0561 | 2.5907 | 0.1209 |
| MCF 10A-H2B-mCherry | Taxol | 71.94 | 13.4 | 0.0024 | 0.0025 | -0.4059 | -0.1917 | 5.0000 | 0.6660 |
| MCF 10A-H2B-mCherry | Neratinib | 71.94 | 13.4 | 0.8657 | 0.9895 | -0.3008 | -0.3025 | 4.0105 | 0.1919 |
| MCF 10A-H2B-mCherry | Neratinib | 74.16 | 13.4 | 1.0683 | 1.3539 | -0.4211 | -0.7255 | 3.7652 | 0.1930 |
| MCF 10A-H2B-mCherry | Palbociclib | 74.16 | 13.4 | 3.0756 | 2.9316 | 0.0118 | 0.0580 | 3.5445 | 0.1026 |
| MCF 10A-H2B-mCherry | Alpelisib | 74.16 | 13.4 | Inf | Inf | 1.0285 | 1.0285 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Taxol | 74.16 | 13.4 | 0.0024 | 0.0026 | -0.2040 | -0.1914 | 4.6471 | 0.6619 |
| MCF 10A-H2B-mCherry | Etoposide | 74.16 | 13.4 | 0.4975 | 0.5185 | -0.1472 | -0.0736 | 3.8402 | 0.3713 |
| MCF 10A-H2B-mCherry | Trametinib | 74.16 | 13.4 | 0.0303 | 0.0298 | -0.0034 | 0.0350 | 5.0000 | 0.3753 |
| MCF 10A-H2B-mCherry | Dasatinib | 74.16 | 13.4 | 2.6047 | 3.0088 | -0.5134 | -0.5296 | 5.0000 | 0.2140 |
| MCF 10A-H2B-mCherry | Vorinostat | 74.16 | 13.4 | 3.3307 | 3.3889 | -0.0246 | -0.0459 | 5.0000 | 0.1122 |
| MCF 10A-H2B-mCherry | Neratinib | 76.38 | 13.4 | 1.1623 | 1.4074 | -0.3862 | -0.4851 | 3.9610 | 0.2050 |