LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Taxol | 27.48 | 13.3 | 0.0019 | 0.0032 | -0.7766 | -0.6351 | 1.5305 | 0.8280 |
| MCF 10A-H2B-mCherry | Neratinib | 27.48 | 13.3 | 0.0548 | 0.0589 | -0.0557 | -0.0726 | 1.9015 | 0.4791 |
| MCF 10A-H2B-mCherry | Trametinib | 27.48 | 13.3 | 0.0023 | 0.0023 | -0.0296 | -0.0065 | 1.5175 | 0.7195 |
| MCF 10A-H2B-mCherry | Vorinostat | 27.48 | 13.3 | 0.6823 | 0.8212 | -0.1496 | -0.1683 | 1.6127 | 0.3903 |
| MCF 10A-H2B-mCherry | Alpelisib | 27.48 | 13.3 | 20.0615 | 109.7735 | 0.5940 | -1.0000 | 0.7179 | 0.0765 |
| MCF 10A-H2B-mCherry | Etoposide | 27.48 | 13.3 | 0.3413 | 0.3499 | -0.0200 | -0.0171 | 1.3558 | 0.3726 |
| MCF 10A-H2B-mCherry | Palbociclib | 29.70 | 13.3 | 0.3052 | 0.4586 | -0.0113 | -0.1395 | 0.8212 | 0.4077 |
| MCF 10A-H2B-mCherry | Taxol | 29.70 | 13.3 | 0.0018 | 0.0028 | -0.7417 | -0.6033 | 1.6514 | 0.8307 |
| MCF 10A-H2B-mCherry | Neratinib | 29.70 | 13.3 | 0.0674 | 0.0723 | -0.0647 | -0.0694 | 1.8850 | 0.4526 |
| MCF 10A-H2B-mCherry | Alpelisib | 29.70 | 13.3 | 27.7483 | 154.7888 | 0.6373 | -0.8744 | 0.6097 | 0.0762 |
| MCF 10A-H2B-mCherry | Dasatinib | 29.70 | 13.3 | 0.4516 | 1.1873 | -0.0290 | -0.3307 | 0.5282 | 0.3756 |
| MCF 10A-H2B-mCherry | Trametinib | 29.70 | 13.3 | 0.0026 | 0.0026 | -0.0081 | 0.0005 | 1.4257 | 0.7007 |
| MCF 10A-H2B-mCherry | Vorinostat | 29.70 | 13.3 | 0.765 | 0.8757 | -0.1253 | -0.1391 | 1.8944 | 0.3675 |
| MCF 10A-H2B-mCherry | Etoposide | 29.70 | 13.3 | 0.3275 | 0.3393 | -0.0061 | -0.0248 | 1.3510 | 0.3816 |
| MCF 10A-H2B-mCherry | Taxol | 31.92 | 13.3 | 0.0016 | 0.0025 | -0.6609 | -0.5655 | 1.5990 | 0.8378 |
| MCF 10A-H2B-mCherry | Neratinib | 31.92 | 13.3 | 0.0841 | 0.0879 | -0.0517 | -0.0471 | 2.0558 | 0.4275 |
| MCF 10A-H2B-mCherry | Palbociclib | 31.92 | 13.3 | 0.373 | 0.8413 | -0.0169 | -0.2786 | 0.6708 | 0.3931 |
| MCF 10A-H2B-mCherry | Alpelisib | 31.92 | 13.3 | Inf | 48.0469 | 0.6505 | -0.3257 | 0.5441 | 0.0840 |
| MCF 10A-H2B-mCherry | Dasatinib | 31.92 | 13.3 | 0.473 | 2.4894 | -0.0595 | -0.5851 | 0.4682 | 0.3814 |
| MCF 10A-H2B-mCherry | Vorinostat | 31.92 | 13.3 | 0.9055 | 1.0076 | -0.1133 | -0.1220 | 2.1792 | 0.3507 |
| MCF 10A-H2B-mCherry | Trametinib | 31.92 | 13.3 | 0.0029 | 0.003 | 0.0010 | -0.0067 | 1.2681 | 0.6896 |
| MCF 10A-H2B-mCherry | Etoposide | 31.92 | 13.3 | 0.316 | 0.3257 | 0.0051 | -0.0205 | 1.3315 | 0.3831 |
| MCF 10A-H2B-mCherry | Taxol | 34.14 | 13.3 | 0.0015 | 0.0022 | -0.6309 | -0.4906 | 1.7169 | 0.8190 |
| MCF 10A-H2B-mCherry | Palbociclib | 34.14 | 13.3 | 0.3733 | 0.7332 | -0.0259 | -0.2347 | 0.6336 | 0.3892 |
| MCF 10A-H2B-mCherry | Neratinib | 34.14 | 13.3 | 0.1196 | 0.1341 | -0.1261 | -0.1217 | 1.9993 | 0.4045 |