LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 20.81 | 13.3 | 0.502 | 0.8536 | -0.2101 | -0.3304 | 0.9626 | 0.4380 |
| MCF 10A-H2B-mCherry | Neratinib | 20.81 | 13.3 | 0.0279 | 0.0275 | 0.0316 | 0.0136 | 1.8649 | 0.5263 |
| MCF 10A-H2B-mCherry | Palbociclib | 20.81 | 13.3 | 0.0818 | 0.0973 | 0.0125 | -0.0498 | 0.9548 | 0.5611 |
| MCF 10A-H2B-mCherry | Trametinib | 20.81 | 13.3 | 0.0023 | 0.0021 | 0.0576 | 0.0696 | 1.6693 | 0.6766 |
| MCF 10A-H2B-mCherry | Alpelisib | 20.81 | 13.3 | 15.1045 | 119.1663 | 0.5557 | -1.0000 | 0.5491 | 0.1104 |
| MCF 10A-H2B-mCherry | Dasatinib | 20.81 | 13.3 | 0.1678 | 0.1291 | 0.0159 | 0.1178 | 1.0222 | 0.4177 |
| MCF 10A-H2B-mCherry | Taxol | 20.81 | 13.3 | 0.0024 | 0.0055 | -0.7843 | -0.7290 | 1.0789 | 0.7803 |
| MCF 10A-H2B-mCherry | Alpelisib | 23.04 | 13.3 | 13.0191 | 67.1327 | 0.5327 | -1.0000 | 0.6881 | 0.0949 |
| MCF 10A-H2B-mCherry | Vorinostat | 23.04 | 13.3 | 0.5079 | 0.7078 | -0.1692 | -0.2294 | 1.1387 | 0.4288 |
| MCF 10A-H2B-mCherry | Etoposide | 23.04 | 13.3 | 0.3745 | 0.3923 | 0.0069 | -0.0274 | 1.1560 | 0.3700 |
| MCF 10A-H2B-mCherry | Neratinib | 23.04 | 13.3 | 0.0319 | 0.033 | -0.0397 | -0.0347 | 1.9183 | 0.5310 |
| MCF 10A-H2B-mCherry | Palbociclib | 23.04 | 13.3 | 0.1204 | 0.1276 | -0.0121 | -0.0170 | 1.1476 | 0.5097 |
| MCF 10A-H2B-mCherry | Dasatinib | 23.04 | 13.3 | 0.2224 | 0.205 | -0.0118 | 0.0328 | 0.8163 | 0.4098 |
| MCF 10A-H2B-mCherry | Trametinib | 23.04 | 13.3 | 0.0021 | 0.0021 | -0.0007 | 0.0178 | 1.5525 | 0.7172 |
| MCF 10A-H2B-mCherry | Taxol | 23.04 | 13.3 | 0.002 | 0.0039 | -0.7844 | -0.6681 | 1.2967 | 0.8096 |
| MCF 10A-H2B-mCherry | Palbociclib | 25.25 | 13.3 | 0.1666 | 0.1855 | -0.0335 | -0.0382 | 1.0133 | 0.4711 |
| MCF 10A-H2B-mCherry | Neratinib | 25.25 | 13.3 | 0.0402 | 0.0424 | -0.0254 | -0.0486 | 1.8311 | 0.5029 |
| MCF 10A-H2B-mCherry | Alpelisib | 25.25 | 13.3 | 13.7447 | 50.8693 | 0.5662 | -0.9329 | 0.8377 | 0.0699 |
| MCF 10A-H2B-mCherry | Vorinostat | 25.25 | 13.3 | 0.5644 | 0.7187 | -0.1603 | -0.1877 | 1.3197 | 0.4052 |
| MCF 10A-H2B-mCherry | Trametinib | 25.25 | 13.3 | 0.0022 | 0.0022 | -0.0214 | -0.0002 | 1.6675 | 0.7253 |
| MCF 10A-H2B-mCherry | Taxol | 25.25 | 13.3 | 0.0019 | 0.0035 | -0.7891 | -0.6591 | 1.4064 | 0.8233 |
| MCF 10A-H2B-mCherry | Etoposide | 25.25 | 13.3 | 0.3754 | 0.3873 | -0.0229 | -0.0209 | 1.3191 | 0.3639 |
| MCF 10A-H2B-mCherry | Dasatinib | 25.25 | 13.3 | 0.313 | 0.4332 | -0.0328 | -0.1134 | 0.6523 | 0.3950 |
| MCF 10A-H2B-mCherry | Etoposide | 27.48 | 13.3 | 0.3413 | 0.3499 | -0.0200 | -0.0171 | 1.3558 | 0.3726 |
| MCF 10A-H2B-mCherry | Trametinib | 27.48 | 13.3 | 0.0023 | 0.0023 | -0.0296 | -0.0065 | 1.5175 | 0.7195 |