LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 71.94 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0105 |
| MCF 10A-H2B-mCherry | Alpelisib | 74.16 | 13.4 | Inf | Inf | 1.0285 | 1.0285 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Alpelisib | 76.38 | 13.4 | Inf | Inf | 0.9533 | 0.9533 | 0.0000 | -0.0076 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.60 | 13.4 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0077 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.82 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Dasatinib | 69.71 | 13.4 | 2.5863 | 2.9033 | -0.3708 | -0.3922 | 5.0000 | 0.2048 |
| MCF 10A-H2B-mCherry | Dasatinib | 71.94 | 13.4 | 2.6626 | 3.0476 | -0.4700 | -0.4838 | 5.0000 | 0.1943 |
| MCF 10A-H2B-mCherry | Dasatinib | 74.16 | 13.4 | 2.6047 | 3.0088 | -0.5134 | -0.5296 | 5.0000 | 0.2140 |
| MCF 10A-H2B-mCherry | Dasatinib | 76.38 | 13.4 | 2.6411 | 3.1142 | -0.6260 | -0.6410 | 5.0000 | 0.2153 |
| MCF 10A-H2B-mCherry | Dasatinib | 78.60 | 13.4 | 2.6077 | 3.0672 | -0.6115 | -0.6256 | 5.0000 | 0.2331 |
| MCF 10A-H2B-mCherry | Dasatinib | 80.82 | 13.4 | 2.6268 | 3.1186 | -0.6670 | -0.6812 | 5.0000 | 0.2539 |
| MCF 10A-H2B-mCherry | Etoposide | 69.71 | 13.4 | 0.5077 | 0.5252 | -0.1330 | -0.0302 | 3.4199 | 0.3350 |
| MCF 10A-H2B-mCherry | Etoposide | 71.94 | 13.4 | 0.541 | 0.5582 | -0.0714 | -0.0338 | 3.5133 | 0.3384 |
| MCF 10A-H2B-mCherry | Etoposide | 74.16 | 13.4 | 0.4975 | 0.5185 | -0.1472 | -0.0736 | 3.8402 | 0.3713 |
| MCF 10A-H2B-mCherry | Etoposide | 76.38 | 13.4 | 0.4846 | 0.465 | -0.0425 | 0.0666 | 4.0059 | 0.3424 |
| MCF 10A-H2B-mCherry | Etoposide | 78.60 | 13.4 | 0.4984 | 0.5033 | -0.1109 | -0.0202 | 3.8858 | 0.3607 |
| MCF 10A-H2B-mCherry | Etoposide | 80.82 | 13.4 | 0.4706 | 0.4799 | -0.2090 | -0.0541 | 4.9985 | 0.3977 |
| MCF 10A-H2B-mCherry | Neratinib | 69.71 | 13.4 | 0.5895 | 0.6414 | -0.3513 | -0.2624 | 5.0000 | 0.2420 |
| MCF 10A-H2B-mCherry | Neratinib | 71.94 | 13.4 | 0.8657 | 0.9895 | -0.3008 | -0.3025 | 4.0105 | 0.1919 |
| MCF 10A-H2B-mCherry | Neratinib | 74.16 | 13.4 | 1.0683 | 1.3539 | -0.4211 | -0.7255 | 3.7652 | 0.1930 |
| MCF 10A-H2B-mCherry | Neratinib | 76.38 | 13.4 | 1.1623 | 1.4074 | -0.3862 | -0.4851 | 3.9610 | 0.2050 |
| MCF 10A-H2B-mCherry | Neratinib | 78.60 | 13.4 | 1.6879 | 2.4766 | -0.2708 | -1.0000 | 3.5041 | 0.1709 |
| MCF 10A-H2B-mCherry | Neratinib | 80.82 | 13.4 | 2.3453 | 2.9216 | -0.1941 | -0.9999 | 5.0000 | 0.1566 |
| MCF 10A-H2B-mCherry | Palbociclib | 69.71 | 13.4 | 3.1977 | 5.394 | -0.0186 | -0.4657 | 1.2682 | 0.1393 |
| MCF 10A-H2B-mCherry | Palbociclib | 74.16 | 13.4 | 3.0756 | 2.9316 | 0.0118 | 0.0580 | 3.5445 | 0.1026 |