LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Dasatinib | 58.58 | 13.3 | 2.2428 | 2.6437 | -0.2202 | -0.2823 | 3.2537 | 0.2503 |
| MCF 10A-H2B-mCherry | Dasatinib | 60.80 | 13.3 | 2.6142 | 2.8457 | -0.2483 | -0.2665 | 5.0000 | 0.2204 |
| MCF 10A-H2B-mCherry | Dasatinib | 63.02 | 13.3 | 2.5721 | 2.791 | -0.2366 | -0.2566 | 5.0000 | 0.2329 |
| MCF 10A-H2B-mCherry | Dasatinib | 65.24 | 13.3 | 2.6262 | 2.9014 | -0.3088 | -0.3272 | 5.0000 | 0.2266 |
| MCF 10A-H2B-mCherry | Dasatinib | 67.47 | 13.3 | 2.6267 | 2.9115 | -0.3174 | -0.3370 | 5.0000 | 0.2139 |
| MCF 10A-H2B-mCherry | Alpelisib | 43.03 | 13.3 | 23.3924 | 88.1783 | 0.7153 | -0.9969 | 0.8352 | 0.0518 |
| MCF 10A-H2B-mCherry | Alpelisib | 27.48 | 13.3 | 20.0615 | 109.7735 | 0.5940 | -1.0000 | 0.7179 | 0.0765 |
| MCF 10A-H2B-mCherry | Etoposide | 49.69 | 13.3 | 0.3623 | 0.3866 | -0.0876 | -0.0529 | 1.5251 | 0.3843 |
| MCF 10A-H2B-mCherry | Alpelisib | 45.25 | 13.3 | Inf | 19.4732 | 0.7923 | -0.0908 | 3.0690 | 0.0228 |
| MCF 10A-H2B-mCherry | Etoposide | 56.36 | 13.3 | 0.3542 | 0.3472 | -0.0096 | 0.0162 | 1.7706 | 0.3758 |
| MCF 10A-H2B-mCherry | Etoposide | 60.80 | 13.3 | 0.3928 | 0.3854 | -0.0303 | 0.0119 | 2.0442 | 0.3554 |
| MCF 10A-H2B-mCherry | Etoposide | 63.02 | 13.3 | 0.4032 | 0.4185 | -0.0977 | -0.0339 | 2.2677 | 0.3679 |
| MCF 10A-H2B-mCherry | Etoposide | 16.73 | 13.3 | 0.56 | 0.6179 | -0.0203 | -0.0675 | 1.2871 | 0.3359 |
| MCF 10A-H2B-mCherry | Etoposide | 18.59 | 13.3 | 0.4472 | 0.5118 | -0.0195 | -0.0809 | 1.1143 | 0.3622 |
| MCF 10A-H2B-mCherry | Etoposide | 20.81 | 13.3 | 0.4019 | 0.4581 | -0.0197 | -0.0737 | 1.0552 | 0.3661 |
| MCF 10A-H2B-mCherry | Etoposide | 23.04 | 13.3 | 0.3745 | 0.3923 | 0.0069 | -0.0274 | 1.1560 | 0.3700 |
| MCF 10A-H2B-mCherry | Etoposide | 25.25 | 13.3 | 0.3754 | 0.3873 | -0.0229 | -0.0209 | 1.3191 | 0.3639 |
| MCF 10A-H2B-mCherry | Etoposide | 27.48 | 13.3 | 0.3413 | 0.3499 | -0.0200 | -0.0171 | 1.3558 | 0.3726 |
| MCF 10A-H2B-mCherry | Etoposide | 29.70 | 13.3 | 0.3275 | 0.3393 | -0.0061 | -0.0248 | 1.3510 | 0.3816 |
| MCF 10A-H2B-mCherry | Etoposide | 31.92 | 13.3 | 0.316 | 0.3257 | 0.0051 | -0.0205 | 1.3315 | 0.3831 |
| MCF 10A-H2B-mCherry | Etoposide | 34.14 | 13.3 | 0.3061 | 0.3153 | -0.0359 | -0.0212 | 1.3752 | 0.3910 |
| MCF 10A-H2B-mCherry | Etoposide | 36.36 | 13.3 | 0.2969 | 0.3117 | -0.0204 | -0.0336 | 1.3320 | 0.3941 |
| MCF 10A-H2B-mCherry | Etoposide | 38.59 | 13.3 | 0.2753 | 0.2877 | -0.0127 | -0.0305 | 1.3445 | 0.4076 |
| MCF 10A-H2B-mCherry | Etoposide | 40.81 | 13.3 | 0.2925 | 0.3059 | -0.0281 | -0.0337 | 1.4528 | 0.4006 |
| MCF 10A-H2B-mCherry | Neratinib | 20.81 | 13.3 | 0.0279 | 0.0275 | 0.0316 | 0.0136 | 1.8649 | 0.5263 |