LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Palbociclib | 76.38 | 13.4 | 3.7937 | 3.9931 | 0.0653 | -0.0691 | 2.1758 | 0.1012 |
| MCF 10A-H2B-mCherry | Palbociclib | 78.60 | 13.4 | 3.8114 | 5.377 | -0.0290 | -0.5698 | 2.1381 | 0.1010 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.82 | 13.4 | 4.3569 | 6.7523 | -0.0503 | -0.7295 | 1.9672 | 0.0940 |
| MCF 10A-H2B-mCherry | Taxol | 69.71 | 13.4 | 0.0023 | 0.0025 | -0.2735 | -0.1573 | 4.8802 | 0.6351 |
| MCF 10A-H2B-mCherry | Taxol | 71.94 | 13.4 | 0.0024 | 0.0025 | -0.4059 | -0.1917 | 5.0000 | 0.6660 |
| MCF 10A-H2B-mCherry | Taxol | 74.16 | 13.4 | 0.0024 | 0.0026 | -0.2040 | -0.1914 | 4.6471 | 0.6619 |
| MCF 10A-H2B-mCherry | Taxol | 76.38 | 13.4 | 0.0027 | 0.003 | -0.3872 | -0.2827 | 5.0000 | 0.7081 |
| MCF 10A-H2B-mCherry | Taxol | 78.60 | 13.4 | 0.0027 | 0.003 | -0.4567 | -0.3897 | 5.0000 | 0.7535 |
| MCF 10A-H2B-mCherry | Taxol | 80.82 | 13.4 | 0.0029 | 0.0033 | -0.4208 | -0.4210 | 5.0000 | 0.7492 |
| MCF 10A-H2B-mCherry | Trametinib | 69.71 | 13.4 | 0.0283 | 0.0275 | -0.0156 | 0.0459 | 4.2625 | 0.3921 |
| MCF 10A-H2B-mCherry | Trametinib | 71.94 | 13.4 | 0.0301 | 0.0295 | -0.0284 | 0.0490 | 5.0000 | 0.3826 |
| MCF 10A-H2B-mCherry | Trametinib | 74.16 | 13.4 | 0.0303 | 0.0298 | -0.0034 | 0.0350 | 5.0000 | 0.3753 |
| MCF 10A-H2B-mCherry | Trametinib | 76.38 | 13.4 | 0.0309 | 0.0305 | -0.0623 | 0.0243 | 5.0000 | 0.3705 |
| MCF 10A-H2B-mCherry | Trametinib | 78.60 | 13.4 | 0.0337 | 0.0328 | 0.0005 | 0.0659 | 5.0000 | 0.3496 |
| MCF 10A-H2B-mCherry | Trametinib | 80.82 | 13.4 | 0.0466 | 0.0449 | 0.0168 | 0.0770 | 4.4772 | 0.3291 |
| MCF 10A-H2B-mCherry | Taxol | 15.91 | 13.5 | 0.0055 | 0.0121 | -0.6952 | -0.7201 | 1.1326 | 0.6312 |
| MCF 10A-H2B-mCherry | Dasatinib | 15.91 | 13.5 | 0.3062 | 0.1466 | 0.1432 | 0.2293 | 0.8331 | 0.3528 |
| MCF 10A-H2B-mCherry | Etoposide | 15.91 | 13.5 | 0.4653 | 0.5125 | -0.0077 | -0.0631 | 1.2303 | 0.3605 |
| MCF 10A-H2B-mCherry | Neratinib | 15.91 | 13.5 | 0.0344 | 0.0274 | 0.1224 | 0.1444 | 1.4878 | 0.4548 |
| MCF 10A-H2B-mCherry | Palbociclib | 15.91 | 13.5 | 0.045 | 0.0365 | 0.1252 | 0.0905 | 0.9568 | 0.5703 |
| MCF 10A-H2B-mCherry | Alpelisib | 15.91 | 13.5 | 18.5716 | 168.3795 | 0.5685 | -1.0000 | 0.4983 | 0.1166 |
| MCF 10A-H2B-mCherry | Trametinib | 15.91 | 13.5 | 0.0058 | 0.003 | 0.3307 | 0.3502 | 1.7943 | 0.4481 |
| MCF 10A-H2B-mCherry | Vorinostat | 15.91 | 13.5 | 0.673 | 1.0022 | -0.2338 | -0.3147 | 1.2258 | 0.4090 |