LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 18.59 | 13.3 | 0.5664 | 1.0687 | -0.2412 | -0.4101 | 0.9460 | 0.4283 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.59 | 13.3 | 16.2872 | 30.1363 | 0.5697 | -0.4075 | 0.6604 | 0.1016 |
| MCF 10A-H2B-mCherry | Dasatinib | 69.71 | 13.4 | 2.5863 | 2.9033 | -0.3708 | -0.3922 | 5.0000 | 0.2048 |
| MCF 10A-H2B-mCherry | Taxol | 78.60 | 13.4 | 0.0027 | 0.003 | -0.4567 | -0.3897 | 5.0000 | 0.7535 |
| MCF 10A-H2B-mCherry | Taxol | 38.59 | 13.3 | 0.0013 | 0.0018 | -0.5016 | -0.3717 | 2.0884 | 0.8013 |
| MCF 10A-H2B-mCherry | Palbociclib | 54.14 | 13.3 | 1.2363 | 2.3521 | 0.0194 | -0.3506 | 0.9829 | 0.2384 |
| MCF 10A-H2B-mCherry | Dasatinib | 67.47 | 13.3 | 2.6267 | 2.9115 | -0.3174 | -0.3370 | 5.0000 | 0.2139 |
| MCF 10A-H2B-mCherry | Taxol | 40.81 | 13.3 | 0.0013 | 0.0017 | -0.3971 | -0.3361 | 2.3974 | 0.7895 |
| MCF 10A-H2B-mCherry | Dasatinib | 29.70 | 13.3 | 0.4516 | 1.1873 | -0.0290 | -0.3307 | 0.5282 | 0.3756 |
| MCF 10A-H2B-mCherry | Vorinostat | 20.81 | 13.3 | 0.502 | 0.8536 | -0.2101 | -0.3304 | 0.9626 | 0.4380 |
| MCF 10A-H2B-mCherry | Dasatinib | 65.24 | 13.3 | 2.6262 | 2.9014 | -0.3088 | -0.3272 | 5.0000 | 0.2266 |
| MCF 10A-H2B-mCherry | Alpelisib | 31.92 | 13.3 | Inf | 48.0469 | 0.6505 | -0.3257 | 0.5441 | 0.0840 |
| MCF 10A-H2B-mCherry | Vorinostat | 15.91 | 13.5 | 0.673 | 1.0022 | -0.2338 | -0.3147 | 1.2258 | 0.4090 |
| MCF 10A-H2B-mCherry | Neratinib | 71.94 | 13.4 | 0.8657 | 0.9895 | -0.3008 | -0.3025 | 4.0105 | 0.1919 |
| MCF 10A-H2B-mCherry | Dasatinib | 56.36 | 13.3 | 2.0599 | 2.5902 | -0.1942 | -0.2943 | 2.4725 | 0.2544 |
| MCF 10A-H2B-mCherry | Neratinib | 65.24 | 13.3 | 0.4103 | 0.49 | -0.3186 | -0.2875 | 3.4867 | 0.2705 |
| MCF 10A-H2B-mCherry | Palbociclib | 63.02 | 13.3 | 1.6501 | 2.7465 | -0.0209 | -0.2830 | 0.8718 | 0.2006 |
| MCF 10A-H2B-mCherry | Taxol | 76.38 | 13.4 | 0.0027 | 0.003 | -0.3872 | -0.2827 | 5.0000 | 0.7081 |
| MCF 10A-H2B-mCherry | Dasatinib | 58.58 | 13.3 | 2.2428 | 2.6437 | -0.2202 | -0.2823 | 3.2537 | 0.2503 |
| MCF 10A-H2B-mCherry | Taxol | 43.03 | 13.3 | 0.0014 | 0.0016 | -0.3983 | -0.2791 | 2.7072 | 0.7654 |
| MCF 10A-H2B-mCherry | Palbociclib | 31.92 | 13.3 | 0.373 | 0.8413 | -0.0169 | -0.2786 | 0.6708 | 0.3931 |
| MCF 10A-H2B-mCherry | Palbociclib | 60.80 | 13.3 | 1.6276 | 2.6679 | -0.0074 | -0.2749 | 0.8841 | 0.2022 |
| MCF 10A-H2B-mCherry | Dasatinib | 60.80 | 13.3 | 2.6142 | 2.8457 | -0.2483 | -0.2665 | 5.0000 | 0.2204 |
| MCF 10A-H2B-mCherry | Neratinib | 69.71 | 13.4 | 0.5895 | 0.6414 | -0.3513 | -0.2624 | 5.0000 | 0.2420 |
| MCF 10A-H2B-mCherry | Dasatinib | 63.02 | 13.3 | 2.5721 | 2.791 | -0.2366 | -0.2566 | 5.0000 | 0.2329 |