LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 80.82 | 13.4 | 0.0466 | 0.0449 | 0.0168 | 0.0770 | 4.4772 | 0.3291 |
| MCF 10A-H2B-mCherry | Palbociclib | 45.25 | 13.3 | 0.4306 | 0.3753 | 0.0172 | 0.0899 | 1.4590 | 0.3094 |
| MCF 10A-H2B-mCherry | Palbociclib | 15.91 | 13.5 | 0.045 | 0.0365 | 0.1252 | 0.0905 | 0.9568 | 0.5703 |
| MCF 10A-H2B-mCherry | Palbociclib | 43.03 | 13.3 | 0.3121 | 0.2618 | 0.0068 | 0.1104 | 1.4192 | 0.3456 |
| MCF 10A-H2B-mCherry | Dasatinib | 20.81 | 13.3 | 0.1678 | 0.1291 | 0.0159 | 0.1178 | 1.0222 | 0.4177 |
| MCF 10A-H2B-mCherry | Neratinib | 16.73 | 13.3 | 0.0359 | 0.03 | 0.1415 | 0.1416 | 1.8404 | 0.4507 |
| MCF 10A-H2B-mCherry | Neratinib | 15.91 | 13.5 | 0.0344 | 0.0274 | 0.1224 | 0.1444 | 1.4878 | 0.4548 |
| MCF 10A-H2B-mCherry | Trametinib | 18.59 | 13.3 | 0.0031 | 0.0024 | 0.1609 | 0.1780 | 1.5913 | 0.5859 |
| MCF 10A-H2B-mCherry | Dasatinib | 18.59 | 13.3 | 0.1649 | 0.1073 | 0.0926 | 0.2004 | 1.1913 | 0.3926 |
| MCF 10A-H2B-mCherry | Dasatinib | 15.91 | 13.5 | 0.3062 | 0.1466 | 0.1432 | 0.2293 | 0.8331 | 0.3528 |
| MCF 10A-H2B-mCherry | Dasatinib | 16.73 | 13.3 | 0.2398 | 0.1356 | 0.1161 | 0.2329 | 1.0987 | 0.3477 |
| MCF 10A-H2B-mCherry | Trametinib | 16.73 | 13.3 | 0.0054 | 0.0032 | 0.1822 | 0.2568 | 1.3893 | 0.5061 |
| MCF 10A-H2B-mCherry | Trametinib | 15.91 | 13.5 | 0.0058 | 0.003 | 0.3307 | 0.3502 | 1.7943 | 0.4481 |
| MCF 10A-H2B-mCherry | Alpelisib | 63.02 | 13.3 | Inf | Inf | 0.8310 | 0.8049 | 0.7013 | 0.0213 |
| MCF 10A-H2B-mCherry | Alpelisib | 65.24 | 13.3 | Inf | Inf | 0.7691 | 0.8264 | 2.5000 | 0.0249 |
| MCF 10A-H2B-mCherry | Alpelisib | 60.80 | 13.3 | Inf | Inf | 0.7722 | 0.8272 | 1.1247 | 0.0073 |
| MCF 10A-H2B-mCherry | Alpelisib | 69.71 | 13.4 | Inf | Inf | 0.8659 | 0.8659 | 0.0000 | 0.0193 |
| MCF 10A-H2B-mCherry | Alpelisib | 67.47 | 13.3 | Inf | Inf | 0.8446 | 0.8821 | 2.5000 | 0.0200 |
| MCF 10A-H2B-mCherry | Alpelisib | 76.38 | 13.4 | Inf | Inf | 0.9533 | 0.9533 | 0.0000 | -0.0076 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.82 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Alpelisib | 71.94 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0105 |
| MCF 10A-H2B-mCherry | Alpelisib | 74.16 | 13.4 | Inf | Inf | 1.0285 | 1.0285 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.60 | 13.4 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0077 |