LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Dasatinib 45.25 13.3
1.0589
4.5149
 -0.0802 -0.7836 0.6356 0.2946
MCF 10A-H2B-mCherry Dasatinib 25.25 13.3
0.313
0.4332
 -0.0328 -0.1134 0.6523 0.3950
MCF 10A-H2B-mCherry Alpelisib 18.59 13.3
16.2872
30.1363
 0.5697 -0.4075 0.6604 0.1016
MCF 10A-H2B-mCherry Palbociclib 31.92 13.3
0.373
0.8413
 -0.0169 -0.2786 0.6708 0.3931
MCF 10A-H2B-mCherry Dasatinib 47.47 13.3
1.2344
5.6634
 -0.1100 -0.9056 0.6840 0.2827
MCF 10A-H2B-mCherry Palbociclib 36.36 13.3
0.3444
0.4474
 -0.0097 -0.0958 0.6863 0.3906
MCF 10A-H2B-mCherry Alpelisib 23.04 13.3
13.0191
67.1327
 0.5327 -1.0000 0.6881 0.0949
MCF 10A-H2B-mCherry Alpelisib 63.02 13.3
Inf
Inf
 0.8310 0.8049 0.7013 0.0213
MCF 10A-H2B-mCherry Alpelisib 27.48 13.3
20.0615
109.7735
 0.5940 -1.0000 0.7179 0.0765
MCF 10A-H2B-mCherry Palbociclib 65.24 13.3
1.9881
6.2593
 -0.0570 -0.7577 0.8015 0.1967
MCF 10A-H2B-mCherry Palbociclib 18.59 13.3
0.0539
0.0586
 0.0305 -0.0240 0.8136 0.5912
MCF 10A-H2B-mCherry Dasatinib 23.04 13.3
0.2224
0.205
 -0.0118 0.0328 0.8163 0.4098
MCF 10A-H2B-mCherry Palbociclib 29.70 13.3
0.3052
0.4586
 -0.0113 -0.1395 0.8212 0.4077
MCF 10A-H2B-mCherry Dasatinib 15.91 13.5
0.3062
0.1466
 0.1432 0.2293 0.8331 0.3528
MCF 10A-H2B-mCherry Alpelisib 43.03 13.3
23.3924
88.1783
 0.7153 -0.9969 0.8352 0.0518
MCF 10A-H2B-mCherry Alpelisib 25.25 13.3
13.7447
50.8693
 0.5662 -0.9329 0.8377 0.0699
MCF 10A-H2B-mCherry Dasatinib 49.69 13.3
1.5612
5.8184
 -0.1606 -0.9355 0.8455 0.2645
MCF 10A-H2B-mCherry Palbociclib 63.02 13.3
1.6501
2.7465
 -0.0209 -0.2830 0.8718 0.2006
MCF 10A-H2B-mCherry Palbociclib 60.80 13.3
1.6276
2.6679
 -0.0074 -0.2749 0.8841 0.2022
MCF 10A-H2B-mCherry Palbociclib 38.59 13.3
0.31
0.29
 0.0116 0.0296 0.9070 0.3835
MCF 10A-H2B-mCherry Palbociclib 58.58 13.3
1.3483
1.7677
 0.0272 -0.1459 0.9164 0.2209
MCF 10A-H2B-mCherry Palbociclib 27.48 13.3
0.2351
0.2704
 -0.0078 -0.0528 0.9324 0.4327
MCF 10A-H2B-mCherry Vorinostat 18.59 13.3
0.5664
1.0687
 -0.2412 -0.4101 0.9460 0.4283
MCF 10A-H2B-mCherry Palbociclib 20.81 13.3
0.0818
0.0973
 0.0125 -0.0498 0.9548 0.5611
MCF 10A-H2B-mCherry Palbociclib 15.91 13.5
0.045
0.0365
 0.1252 0.0905 0.9568 0.5703