LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 58.58 | 13.3 | 2.0321 | 2.0717 | -0.0920 | -0.0454 | 4.6303 | 0.1798 |
| MCF 10A-H2B-mCherry | Vorinostat | 56.36 | 13.3 | 1.8971 | 1.9476 | -0.1068 | -0.0598 | 4.3974 | 0.1866 |
| MCF 10A-H2B-mCherry | Vorinostat | 54.14 | 13.3 | 1.8708 | 1.9209 | -0.0884 | -0.0604 | 4.4214 | 0.1907 |
| MCF 10A-H2B-mCherry | Neratinib | 71.94 | 13.4 | 0.8657 | 0.9895 | -0.3008 | -0.3025 | 4.0105 | 0.1919 |
| MCF 10A-H2B-mCherry | Neratinib | 74.16 | 13.4 | 1.0683 | 1.3539 | -0.4211 | -0.7255 | 3.7652 | 0.1930 |
| MCF 10A-H2B-mCherry | Dasatinib | 71.94 | 13.4 | 2.6626 | 3.0476 | -0.4700 | -0.4838 | 5.0000 | 0.1943 |
| MCF 10A-H2B-mCherry | Palbociclib | 65.24 | 13.3 | 1.9881 | 6.2593 | -0.0570 | -0.7577 | 0.8015 | 0.1967 |
| MCF 10A-H2B-mCherry | Palbociclib | 63.02 | 13.3 | 1.6501 | 2.7465 | -0.0209 | -0.2830 | 0.8718 | 0.2006 |
| MCF 10A-H2B-mCherry | Vorinostat | 51.92 | 13.3 | 1.8216 | 1.8954 | -0.1164 | -0.0792 | 4.1224 | 0.2010 |
| MCF 10A-H2B-mCherry | Palbociclib | 60.80 | 13.3 | 1.6276 | 2.6679 | -0.0074 | -0.2749 | 0.8841 | 0.2022 |
| MCF 10A-H2B-mCherry | Dasatinib | 69.71 | 13.4 | 2.5863 | 2.9033 | -0.3708 | -0.3922 | 5.0000 | 0.2048 |
| MCF 10A-H2B-mCherry | Neratinib | 76.38 | 13.4 | 1.1623 | 1.4074 | -0.3862 | -0.4851 | 3.9610 | 0.2050 |
| MCF 10A-H2B-mCherry | Dasatinib | 67.47 | 13.3 | 2.6267 | 2.9115 | -0.3174 | -0.3370 | 5.0000 | 0.2139 |
| MCF 10A-H2B-mCherry | Dasatinib | 74.16 | 13.4 | 2.6047 | 3.0088 | -0.5134 | -0.5296 | 5.0000 | 0.2140 |
| MCF 10A-H2B-mCherry | Dasatinib | 76.38 | 13.4 | 2.6411 | 3.1142 | -0.6260 | -0.6410 | 5.0000 | 0.2153 |
| MCF 10A-H2B-mCherry | Vorinostat | 49.69 | 13.3 | 1.7722 | 1.8866 | -0.1393 | -0.1148 | 3.5508 | 0.2155 |
| MCF 10A-H2B-mCherry | Dasatinib | 60.80 | 13.3 | 2.6142 | 2.8457 | -0.2483 | -0.2665 | 5.0000 | 0.2204 |
| MCF 10A-H2B-mCherry | Palbociclib | 58.58 | 13.3 | 1.3483 | 1.7677 | 0.0272 | -0.1459 | 0.9164 | 0.2209 |
| MCF 10A-H2B-mCherry | Dasatinib | 65.24 | 13.3 | 2.6262 | 2.9014 | -0.3088 | -0.3272 | 5.0000 | 0.2266 |
| MCF 10A-H2B-mCherry | Palbociclib | 56.36 | 13.3 | 1.3646 | 2.1723 | 0.0395 | -0.2475 | 1.0052 | 0.2296 |
| MCF 10A-H2B-mCherry | Dasatinib | 63.02 | 13.3 | 2.5721 | 2.791 | -0.2366 | -0.2566 | 5.0000 | 0.2329 |
| MCF 10A-H2B-mCherry | Dasatinib | 78.60 | 13.4 | 2.6077 | 3.0672 | -0.6115 | -0.6256 | 5.0000 | 0.2331 |
| MCF 10A-H2B-mCherry | Vorinostat | 47.47 | 13.3 | 1.6384 | 1.7629 | -0.1376 | -0.1259 | 3.2107 | 0.2336 |
| MCF 10A-H2B-mCherry | Neratinib | 67.47 | 13.3 | 0.5412 | 0.5856 | -0.2595 | -0.1969 | 3.8839 | 0.2374 |
| MCF 10A-H2B-mCherry | Palbociclib | 54.14 | 13.3 | 1.2363 | 2.3521 | 0.0194 | -0.3506 | 0.9829 | 0.2384 |