LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 31.92 | 13.3 | Inf | 48.0469 | 0.6505 | -0.3257 | 0.5441 | 0.0840 |
| MCF 10A-H2B-mCherry | Alpelisib | 16.73 | 13.3 | 19.6489 | 124.3425 | 0.6341 | -0.9991 | 0.5951 | 0.0849 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.82 | 13.4 | 4.3569 | 6.7523 | -0.0503 | -0.7295 | 1.9672 | 0.0940 |
| MCF 10A-H2B-mCherry | Alpelisib | 23.04 | 13.3 | 13.0191 | 67.1327 | 0.5327 | -1.0000 | 0.6881 | 0.0949 |
| MCF 10A-H2B-mCherry | Vorinostat | 78.60 | 13.4 | 3.6487 | 3.6037 | 0.0164 | 0.0174 | 5.0000 | 0.0967 |
| MCF 10A-H2B-mCherry | Vorinostat | 71.94 | 13.4 | 3.2871 | 3.3126 | -0.0160 | -0.0202 | 5.0000 | 0.0996 |
| MCF 10A-H2B-mCherry | Palbociclib | 78.60 | 13.4 | 3.8114 | 5.377 | -0.0290 | -0.5698 | 2.1381 | 0.1010 |
| MCF 10A-H2B-mCherry | Palbociclib | 76.38 | 13.4 | 3.7937 | 3.9931 | 0.0653 | -0.0691 | 2.1758 | 0.1012 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.59 | 13.3 | 16.2872 | 30.1363 | 0.5697 | -0.4075 | 0.6604 | 0.1016 |
| MCF 10A-H2B-mCherry | Palbociclib | 74.16 | 13.4 | 3.0756 | 2.9316 | 0.0118 | 0.0580 | 3.5445 | 0.1026 |
| MCF 10A-H2B-mCherry | Vorinostat | 69.71 | 13.4 | 3.1094 | 3.0871 | 0.0108 | 0.0168 | 5.0000 | 0.1075 |
| MCF 10A-H2B-mCherry | Alpelisib | 20.81 | 13.3 | 15.1045 | 119.1663 | 0.5557 | -1.0000 | 0.5491 | 0.1104 |
| MCF 10A-H2B-mCherry | Vorinostat | 74.16 | 13.4 | 3.3307 | 3.3889 | -0.0246 | -0.0459 | 5.0000 | 0.1122 |
| MCF 10A-H2B-mCherry | Vorinostat | 76.38 | 13.4 | 3.3759 | 3.4083 | -0.0226 | -0.0245 | 5.0000 | 0.1154 |
| MCF 10A-H2B-mCherry | Alpelisib | 15.91 | 13.5 | 18.5716 | 168.3795 | 0.5685 | -1.0000 | 0.4983 | 0.1166 |
| MCF 10A-H2B-mCherry | Palbociclib | 71.94 | 13.4 | 2.7362 | 2.5853 | 0.0380 | 0.0561 | 2.5907 | 0.1209 |
| MCF 10A-H2B-mCherry | Vorinostat | 80.82 | 13.4 | 3.3561 | 3.3984 | -0.0514 | -0.0324 | 5.0000 | 0.1236 |
| MCF 10A-H2B-mCherry | Vorinostat | 67.47 | 13.3 | 2.8259 | 2.865 | -0.0319 | -0.0356 | 5.0000 | 0.1279 |
| MCF 10A-H2B-mCherry | Palbociclib | 69.71 | 13.4 | 3.1977 | 5.394 | -0.0186 | -0.4657 | 1.2682 | 0.1393 |
| MCF 10A-H2B-mCherry | Vorinostat | 65.24 | 13.3 | 2.4454 | 2.4775 | -0.0465 | -0.0353 | 5.0000 | 0.1445 |
| MCF 10A-H2B-mCherry | Neratinib | 80.82 | 13.4 | 2.3453 | 2.9216 | -0.1941 | -0.9999 | 5.0000 | 0.1566 |
| MCF 10A-H2B-mCherry | Vorinostat | 60.80 | 13.3 | 2.2188 | 2.2676 | -0.0773 | -0.0554 | 4.8049 | 0.1568 |
| MCF 10A-H2B-mCherry | Vorinostat | 63.02 | 13.3 | 2.2236 | 2.2495 | -0.0400 | -0.0312 | 5.0000 | 0.1616 |
| MCF 10A-H2B-mCherry | Neratinib | 78.60 | 13.4 | 1.6879 | 2.4766 | -0.2708 | -1.0000 | 3.5041 | 0.1709 |
| MCF 10A-H2B-mCherry | Palbociclib | 67.47 | 13.3 | 2.3141 | 4.1619 | 0.0014 | -0.4295 | 1.0422 | 0.1732 |