LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 29.70 | 13.3 | 0.0026 | 0.0026 | -0.0081 | 0.0005 | 1.4257 | 0.7007 |
| MCF 10A-H2B-mCherry | Taxol | 49.69 | 13.3 | 0.0016 | 0.0017 | -0.3046 | -0.2186 | 3.6106 | 0.7027 |
| MCF 10A-H2B-mCherry | Taxol | 65.24 | 13.3 | 0.002 | 0.0022 | -0.3431 | -0.2472 | 4.2654 | 0.7033 |
| MCF 10A-H2B-mCherry | Taxol | 76.38 | 13.4 | 0.0027 | 0.003 | -0.3872 | -0.2827 | 5.0000 | 0.7081 |
| MCF 10A-H2B-mCherry | Taxol | 18.59 | 13.3 | 0.0034 | 0.0077 | -0.7352 | -0.7179 | 1.1107 | 0.7117 |
| MCF 10A-H2B-mCherry | Trametinib | 23.04 | 13.3 | 0.0021 | 0.0021 | -0.0007 | 0.0178 | 1.5525 | 0.7172 |
| MCF 10A-H2B-mCherry | Taxol | 47.47 | 13.3 | 0.0014 | 0.0016 | -0.3185 | -0.2225 | 3.3773 | 0.7193 |
| MCF 10A-H2B-mCherry | Trametinib | 27.48 | 13.3 | 0.0023 | 0.0023 | -0.0296 | -0.0065 | 1.5175 | 0.7195 |
| MCF 10A-H2B-mCherry | Trametinib | 25.25 | 13.3 | 0.0022 | 0.0022 | -0.0214 | -0.0002 | 1.6675 | 0.7253 |
| MCF 10A-H2B-mCherry | Taxol | 45.25 | 13.3 | 0.0014 | 0.0016 | -0.2993 | -0.2321 | 3.0578 | 0.7257 |
| MCF 10A-H2B-mCherry | Taxol | 80.82 | 13.4 | 0.0029 | 0.0033 | -0.4208 | -0.4210 | 5.0000 | 0.7492 |
| MCF 10A-H2B-mCherry | Taxol | 78.60 | 13.4 | 0.0027 | 0.003 | -0.4567 | -0.3897 | 5.0000 | 0.7535 |
| MCF 10A-H2B-mCherry | Taxol | 43.03 | 13.3 | 0.0014 | 0.0016 | -0.3983 | -0.2791 | 2.7072 | 0.7654 |
| MCF 10A-H2B-mCherry | Taxol | 20.81 | 13.3 | 0.0024 | 0.0055 | -0.7843 | -0.7290 | 1.0789 | 0.7803 |
| MCF 10A-H2B-mCherry | Taxol | 40.81 | 13.3 | 0.0013 | 0.0017 | -0.3971 | -0.3361 | 2.3974 | 0.7895 |
| MCF 10A-H2B-mCherry | Taxol | 38.59 | 13.3 | 0.0013 | 0.0018 | -0.5016 | -0.3717 | 2.0884 | 0.8013 |
| MCF 10A-H2B-mCherry | Taxol | 23.04 | 13.3 | 0.002 | 0.0039 | -0.7844 | -0.6681 | 1.2967 | 0.8096 |
| MCF 10A-H2B-mCherry | Taxol | 36.36 | 13.3 | 0.0014 | 0.002 | -0.5106 | -0.4415 | 1.8237 | 0.8179 |
| MCF 10A-H2B-mCherry | Taxol | 34.14 | 13.3 | 0.0015 | 0.0022 | -0.6309 | -0.4906 | 1.7169 | 0.8190 |
| MCF 10A-H2B-mCherry | Taxol | 25.25 | 13.3 | 0.0019 | 0.0035 | -0.7891 | -0.6591 | 1.4064 | 0.8233 |
| MCF 10A-H2B-mCherry | Taxol | 27.48 | 13.3 | 0.0019 | 0.0032 | -0.7766 | -0.6351 | 1.5305 | 0.8280 |
| MCF 10A-H2B-mCherry | Taxol | 29.70 | 13.3 | 0.0018 | 0.0028 | -0.7417 | -0.6033 | 1.6514 | 0.8307 |
| MCF 10A-H2B-mCherry | Taxol | 31.92 | 13.3 | 0.0016 | 0.0025 | -0.6609 | -0.5655 | 1.5990 | 0.8378 |