LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Etoposide 76.38 13.4
0.4846
0.465
 -0.0425 0.0666 4.0059 0.3424
MCF 10A-H2B-mCherry Palbociclib 40.81 13.3
0.3019
0.2687
 0.0113 0.0663 1.1591 0.3735
MCF 10A-H2B-mCherry Trametinib 78.60 13.4
0.0337
0.0328
 0.0005 0.0659 5.0000 0.3496
MCF 10A-H2B-mCherry Palbociclib 47.47 13.3
0.5861
0.5407
 0.0540 0.0586 1.4383 0.2850
MCF 10A-H2B-mCherry Palbociclib 74.16 13.4
3.0756
2.9316
 0.0118 0.0580 3.5445 0.1026
MCF 10A-H2B-mCherry Palbociclib 71.94 13.4
2.7362
2.5853
 0.0380 0.0561 2.5907 0.1209
MCF 10A-H2B-mCherry Trametinib 67.47 13.3
0.0241
0.0235
 0.0230 0.0543 4.6584 0.4056
MCF 10A-H2B-mCherry Trametinib 47.47 13.3
0.014
0.0132
 0.0446 0.0490 1.9591 0.5006
MCF 10A-H2B-mCherry Trametinib 71.94 13.4
0.0301
0.0295
 -0.0284 0.0490 5.0000 0.3826
MCF 10A-H2B-mCherry Trametinib 69.71 13.4
0.0283
0.0275
 -0.0156 0.0459 4.2625 0.3921
MCF 10A-H2B-mCherry Trametinib 60.80 13.3
0.0203
0.0196
 0.0037 0.0448 2.6253 0.4458
MCF 10A-H2B-mCherry Trametinib 65.24 13.3
0.0216
0.0211
 0.0017 0.0439 4.0050 0.4213
MCF 10A-H2B-mCherry Trametinib 51.92 13.3
0.0175
0.0167
 0.0376 0.0432 1.9155 0.4714
MCF 10A-H2B-mCherry Trametinib 49.69 13.3
0.0178
0.017
 0.0450 0.0418 2.0225 0.4779
MCF 10A-H2B-mCherry Trametinib 74.16 13.4
0.0303
0.0298
 -0.0034 0.0350 5.0000 0.3753
MCF 10A-H2B-mCherry Dasatinib 23.04 13.3
0.2224
0.205
 -0.0118 0.0328 0.8163 0.4098
MCF 10A-H2B-mCherry Trametinib 56.36 13.3
0.0178
0.0174
 0.0306 0.0301 2.2588 0.4660
MCF 10A-H2B-mCherry Palbociclib 38.59 13.3
0.31
0.29
 0.0116 0.0296 0.9070 0.3835
MCF 10A-H2B-mCherry Trametinib 63.02 13.3
0.0192
0.0188
 -0.0159 0.0290 2.7555 0.4494
MCF 10A-H2B-mCherry Trametinib 76.38 13.4
0.0309
0.0305
 -0.0623 0.0243 5.0000 0.3705
MCF 10A-H2B-mCherry Trametinib 58.58 13.3
0.019
0.0186
 0.0026 0.0225 2.1563 0.4585
MCF 10A-H2B-mCherry Trametinib 54.14 13.3
0.018
0.0175
 0.0175 0.0215 1.8780 0.4726
MCF 10A-H2B-mCherry Trametinib 23.04 13.3
0.0021
0.0021
 -0.0007 0.0178 1.5525 0.7172
MCF 10A-H2B-mCherry Vorinostat 78.60 13.4
3.6487
3.6037
 0.0164 0.0174 5.0000 0.0967
MCF 10A-H2B-mCherry Vorinostat 69.71 13.4
3.1094
3.0871
 0.0108 0.0168 5.0000 0.1075