LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Dasatinib | 65.24 | 13.3 | 2.6262 | 2.9014 | -0.3088 | -0.3272 | 5.0000 | 0.2266 |
| MCF 10A-H2B-mCherry | Dasatinib | 63.02 | 13.3 | 2.5721 | 2.791 | -0.2366 | -0.2566 | 5.0000 | 0.2329 |
| MCF 10A-H2B-mCherry | Vorinostat | 71.94 | 13.4 | 3.2871 | 3.3126 | -0.0160 | -0.0202 | 5.0000 | 0.0996 |
| MCF 10A-H2B-mCherry | Dasatinib | 60.80 | 13.3 | 2.6142 | 2.8457 | -0.2483 | -0.2665 | 5.0000 | 0.2204 |
| MCF 10A-H2B-mCherry | Neratinib | 80.82 | 13.4 | 2.3453 | 2.9216 | -0.1941 | -0.9999 | 5.0000 | 0.1566 |
| MCF 10A-H2B-mCherry | Neratinib | 69.71 | 13.4 | 0.5895 | 0.6414 | -0.3513 | -0.2624 | 5.0000 | 0.2420 |
| MCF 10A-H2B-mCherry | Dasatinib | 74.16 | 13.4 | 2.6047 | 3.0088 | -0.5134 | -0.5296 | 5.0000 | 0.2140 |
| MCF 10A-H2B-mCherry | Taxol | 76.38 | 13.4 | 0.0027 | 0.003 | -0.3872 | -0.2827 | 5.0000 | 0.7081 |
| MCF 10A-H2B-mCherry | Vorinostat | 74.16 | 13.4 | 3.3307 | 3.3889 | -0.0246 | -0.0459 | 5.0000 | 0.1122 |
| MCF 10A-H2B-mCherry | Etoposide | 80.82 | 13.4 | 0.4706 | 0.4799 | -0.2090 | -0.0541 | 4.9985 | 0.3977 |
| MCF 10A-H2B-mCherry | Taxol | 69.71 | 13.4 | 0.0023 | 0.0025 | -0.2735 | -0.1573 | 4.8802 | 0.6351 |
| MCF 10A-H2B-mCherry | Taxol | 58.58 | 13.3 | 0.0017 | 0.0018 | -0.2303 | -0.1683 | 4.8617 | 0.6739 |
| MCF 10A-H2B-mCherry | Vorinostat | 60.80 | 13.3 | 2.2188 | 2.2676 | -0.0773 | -0.0554 | 4.8049 | 0.1568 |
| MCF 10A-H2B-mCherry | Neratinib | 45.25 | 13.3 | 0.2344 | 0.2372 | -0.1712 | -0.0290 | 4.7746 | 0.2829 |
| MCF 10A-H2B-mCherry | Taxol | 60.80 | 13.3 | 0.0017 | 0.0018 | -0.1470 | -0.1634 | 4.7707 | 0.6633 |
| MCF 10A-H2B-mCherry | Trametinib | 67.47 | 13.3 | 0.0241 | 0.0235 | 0.0230 | 0.0543 | 4.6584 | 0.4056 |
| MCF 10A-H2B-mCherry | Taxol | 74.16 | 13.4 | 0.0024 | 0.0026 | -0.2040 | -0.1914 | 4.6471 | 0.6619 |
| MCF 10A-H2B-mCherry | Vorinostat | 58.58 | 13.3 | 2.0321 | 2.0717 | -0.0920 | -0.0454 | 4.6303 | 0.1798 |
| MCF 10A-H2B-mCherry | Neratinib | 47.47 | 13.3 | 0.2624 | 0.2623 | -0.0860 | -0.0002 | 4.4904 | 0.2689 |
| MCF 10A-H2B-mCherry | Trametinib | 80.82 | 13.4 | 0.0466 | 0.0449 | 0.0168 | 0.0770 | 4.4772 | 0.3291 |
| MCF 10A-H2B-mCherry | Vorinostat | 54.14 | 13.3 | 1.8708 | 1.9209 | -0.0884 | -0.0604 | 4.4214 | 0.1907 |
| MCF 10A-H2B-mCherry | Vorinostat | 56.36 | 13.3 | 1.8971 | 1.9476 | -0.1068 | -0.0598 | 4.3974 | 0.1866 |
| MCF 10A-H2B-mCherry | Taxol | 51.92 | 13.3 | 0.0016 | 0.0016 | 0.0999 | -0.0736 | 4.3434 | 0.6212 |
| MCF 10A-H2B-mCherry | Taxol | 54.14 | 13.3 | 0.0016 | 0.0017 | -0.1153 | -0.1257 | 4.3153 | 0.6536 |
| MCF 10A-H2B-mCherry | Taxol | 56.36 | 13.3 | 0.0016 | 0.0017 | -0.1584 | -0.1428 | 4.2867 | 0.6635 |