LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Taxol | 16.73 | 13.3 | 0.0047 | 0.0097 | -0.6834 | -0.7046 | 1.2187 | 0.6742 |
| MCF 10A-H2B-mCherry | Taxol | 58.58 | 13.3 | 0.0017 | 0.0018 | -0.2303 | -0.1683 | 4.8617 | 0.6739 |
| MCF 10A-H2B-mCherry | Trametinib | 34.14 | 13.3 | 0.0035 | 0.0036 | -0.0098 | -0.0135 | 1.1220 | 0.6699 |
| MCF 10A-H2B-mCherry | Taxol | 71.94 | 13.4 | 0.0024 | 0.0025 | -0.4059 | -0.1917 | 5.0000 | 0.6660 |
| MCF 10A-H2B-mCherry | Taxol | 56.36 | 13.3 | 0.0016 | 0.0017 | -0.1584 | -0.1428 | 4.2867 | 0.6635 |
| MCF 10A-H2B-mCherry | Taxol | 60.80 | 13.3 | 0.0017 | 0.0018 | -0.1470 | -0.1634 | 4.7707 | 0.6633 |
| MCF 10A-H2B-mCherry | Taxol | 74.16 | 13.4 | 0.0024 | 0.0026 | -0.2040 | -0.1914 | 4.6471 | 0.6619 |
| MCF 10A-H2B-mCherry | Taxol | 54.14 | 13.3 | 0.0016 | 0.0017 | -0.1153 | -0.1257 | 4.3153 | 0.6536 |
| MCF 10A-H2B-mCherry | Trametinib | 36.36 | 13.3 | 0.0039 | 0.0039 | 0.0199 | 0.0015 | 1.1076 | 0.6499 |
| MCF 10A-H2B-mCherry | Taxol | 69.71 | 13.4 | 0.0023 | 0.0025 | -0.2735 | -0.1573 | 4.8802 | 0.6351 |
| MCF 10A-H2B-mCherry | Trametinib | 38.59 | 13.3 | 0.005 | 0.0052 | 0.0005 | -0.0200 | 0.9820 | 0.6323 |
| MCF 10A-H2B-mCherry | Taxol | 15.91 | 13.5 | 0.0055 | 0.0121 | -0.6952 | -0.7201 | 1.1326 | 0.6312 |
| MCF 10A-H2B-mCherry | Taxol | 51.92 | 13.3 | 0.0016 | 0.0016 | 0.0999 | -0.0736 | 4.3434 | 0.6212 |
| MCF 10A-H2B-mCherry | Taxol | 63.02 | 13.3 | 0.0018 | 0.0018 | 0.0879 | -0.0920 | 5.0000 | 0.6130 |
| MCF 10A-H2B-mCherry | Trametinib | 40.81 | 13.3 | 0.0061 | 0.0062 | 0.0257 | -0.0045 | 1.0021 | 0.6032 |
| MCF 10A-H2B-mCherry | Taxol | 67.47 | 13.3 | 0.0019 | 0.002 | -0.1129 | -0.0505 | 5.0000 | 0.6016 |
| MCF 10A-H2B-mCherry | Palbociclib | 18.59 | 13.3 | 0.0539 | 0.0586 | 0.0305 | -0.0240 | 0.8136 | 0.5912 |
| MCF 10A-H2B-mCherry | Palbociclib | 16.73 | 13.3 | 0.0533 | 0.0647 | 0.0467 | -0.0559 | 0.5491 | 0.5897 |
| MCF 10A-H2B-mCherry | Trametinib | 18.59 | 13.3 | 0.0031 | 0.0024 | 0.1609 | 0.1780 | 1.5913 | 0.5859 |
| MCF 10A-H2B-mCherry | Trametinib | 43.03 | 13.3 | 0.0081 | 0.0081 | 0.0108 | -0.0039 | 1.0504 | 0.5720 |
| MCF 10A-H2B-mCherry | Palbociclib | 15.91 | 13.5 | 0.045 | 0.0365 | 0.1252 | 0.0905 | 0.9568 | 0.5703 |
| MCF 10A-H2B-mCherry | Palbociclib | 20.81 | 13.3 | 0.0818 | 0.0973 | 0.0125 | -0.0498 | 0.9548 | 0.5611 |
| MCF 10A-H2B-mCherry | Neratinib | 23.04 | 13.3 | 0.0319 | 0.033 | -0.0397 | -0.0347 | 1.9183 | 0.5310 |
| MCF 10A-H2B-mCherry | Trametinib | 45.25 | 13.3 | 0.0119 | 0.0117 | 0.0297 | 0.0122 | 1.2484 | 0.5302 |
| MCF 10A-H2B-mCherry | Neratinib | 20.81 | 13.3 | 0.0279 | 0.0275 | 0.0316 | 0.0136 | 1.8649 | 0.5263 |