Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Torkinib
MTOR
MTOR
 0.0008 0.0021 0.0184 -0.5713 -0.3826 -0.2014 -0.6715 -0.4047 -0.1504 0.3324 0.3720 0.5454 0.6694 0.8411 1.0104 0.0046 0.0211 0.0646
Glycyl-H-1152
ROCK2
N/A
 7.8389 29.5632 100.0000 0.0725 0.4318 0.6407 -0.4259 0.0666 0.6245 0.3449 0.9010 2.0476 0.0704 0.1476 0.1891 2.5420 16.8696 100.0000
Triciribine
AKT
AKT
 0.1497 1.0069 10.2321 -0.2208 0.0730 0.3595 -0.6783 -0.3270 0.0049 0.3693 0.5173 0.9769 0.1961 0.3180 0.4712 0.2958 1.3169 18.2553
Vinorelbine
TUBB
TUBB
 0.0079 0.0130 0.0470 -0.9358 -0.8653 -0.6758 -1.0000 -0.5683 -0.3360 0.3815 2.2644 3.6055 0.6197 0.8320 1.0409 0.0132 0.0302 0.9743
Ixabepilone
TUBB
TUBB
 0.0045 0.0114 0.0487 -0.9765 -0.9460 -0.8485 -0.9892 -0.7196 -0.5742 0.3937 0.7623 1.6684 0.6842 0.8505 0.9658 0.0102 0.0892 0.7025
5-DFUR
TYMS
TYMS
 68.5295 100.0000 100.0000 -0.1871 -0.0208 0.0399 -0.5625 -0.3158 -0.1425 0.3943 0.5084 0.6195 0.2584 0.3100 0.3856 100.0000 100.0000 100.0000
CGC-11047
Polyamine analogue
N/A
 43.1451 85.4630 100.0000 -0.8722 -0.7234 -0.2437 -1.0000 -0.9172 -0.4365 0.4134 0.5735 1.1488 0.3172 0.3971 0.4905 94.6485 100.0000 100.0000
Trametinib
MEK
MAPK
 0.1119 60.3200 100.0000 0.2676 0.5669 0.7582 0.2515 0.4183 0.5896 0.4854 1.1532 1.7735 0.0718 0.1864 0.3779 0.0100 0.4479 33.6419
Tozasertib
AURK/FLT3/ABL/JAK2
AURK
 0.9523 4.3787 11.8540 -0.5661 -0.3376 -0.0359 -1.0000 -1.0000 -0.4350 0.4858 0.8218 1.3502 0.1794 0.3014 0.3656 4.7346 16.5294 34.8041
Ispinesib
KSP
Kinesin
 0.0263 0.0439 0.1261 -0.9817 -0.9567 -0.8688 -1.0000 -0.9800 -0.6258 0.4997 1.2912 3.1780 0.5293 0.6720 0.8104 0.0357 0.4315 1.3590
Afatinib
EGFR/HER2
ErbB
 0.1253 1.5517 2.4757 -0.9553 -0.9200 -0.8460 -1.0000 -1.0000 -0.9391 0.5080 1.0283 1.7263 0.4620 0.5435 0.6679 1.1116 3.3143 4.9447
5-FU
TYMS
TYMS
 43.5628 98.8715 100.0000 -0.6126 -0.4736 -0.0711 -0.8532 -0.6532 -0.1200 0.5225 0.5967 0.7832 0.3295 0.4853 0.6100 100.0000 100.0000 100.0000
Etoposide
TOP2
TOP
 1.1610 2.9708 7.6285 -0.6938 -0.4841 -0.2079 -0.7406 -0.5842 -0.4690 0.5531 0.8108 1.2247 0.3770 0.4769 0.5711 4.4274 7.6731 19.6965
Gemcitabine
DNA replication
DNA replication
 0.0255 0.1767 1.3221 -0.1534 0.1060 0.2747 -0.1430 0.1441 0.3026 0.5558 1.2204 2.6334 0.3723 0.5392 0.7460 0.0153 0.0741 0.2614
Topotecan
TOP1
TOP
 0.0324 0.1223 0.4672 -0.7615 -0.5906 -0.2740 -0.8265 -0.6901 -0.4582 0.5573 0.7931 1.1373 0.5801 0.7088 0.8375 0.0774 0.7078 1.2170
ZM-447439
AURK
AURK
 3.5193 19.1991 100.0000 -0.0403 0.4141 0.5578 -0.1176 0.3301 0.5652 0.5578 1.0337 2.9596 0.1428 0.2012 0.3024 0.6732 2.5837 16.4745
TPCA-1
IKK
NFKB
 4.9121 23.5816 100.0000 0.0988 0.4346 0.6277 -0.1071 0.3912 0.5674 0.5796 1.2158 2.2892 0.0966 0.1616 0.2244 2.5700 5.7466 43.2238
Omipalisib
PI3K
PI3K
 0.0049 0.0154 0.0397 -0.8281 -0.5752 -0.4164 -0.8004 -0.5070 -0.2908 0.6200 0.7592 0.9464 0.6332 0.8101 0.9689 0.0158 0.0370 0.0945
Lestaurtinib
FLT3/JAK2/TrkA
RTK
 0.2491 0.7096 1.5478 -0.9565 -0.8762 -0.7290 -1.0000 -1.0000 -0.9202 0.6212 0.8572 1.4388 0.3615 0.4228 0.5481 1.3258 2.5025 5.3389
Oxaliplatin
DNA cross-linker
DNA cross-linker
 3.2681 4.9333 12.0662 -0.9391 -0.8084 -0.7104 -1.0000 -1.0000 -0.9516 0.6228 0.7486 1.0057 0.4005 0.5419 0.5768 14.7918 22.6957 42.6124
(Z)-4-Hydroxytamoxifen
ESR1
N/A
 38.2142 72.1652 100.0000 -0.2149 0.3051 0.6418 -0.8145 -0.0997 0.5442 0.6236 1.8012 2.9451 0.0928 0.1395 0.2253 17.7725 43.7586 100.0000
Pevonedistat
NAE1
NAE1
 0.1439 0.3445 1.2615 -0.3074 -0.0880 0.0407 -0.4612 -0.1540 0.0480 0.6476 0.9529 1.4328 0.3433 0.4344 0.5442 0.1672 0.7014 1.4696
GSK1070916
AURK
AURK
 0.6046 3.0981 6.6549 -0.8474 -0.6391 -0.3610 -1.0000 -1.0000 -0.9999 0.6499 0.9902 1.5949 0.2113 0.2924 0.4314 3.5405 8.2453 15.6107
Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
 36.5873 68.4588 100.0000 -0.7737 -0.2023 0.2203 -0.7439 -0.3900 0.2345 0.6570 1.9429 3.4993 0.1339 0.2188 0.2978 54.8881 71.4700 100.0000
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571