Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)
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| Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | GR50 lower quartile | GR50 median | GR50 upper quartile | GRmax lower quartile | GRmax median | GRmax upper quartile | GRinf lower quartile | GRinf median | GRinf upper quartile | Hill Coefficient lower quartile | Hill Coefficient median | Hill Coefficient upper quartile | GR_AOC lower quartile | GR_AOC median | GR_AOC upper quartile | GEC50 lower quartile | GEC50 median | GEC50 upper quartile |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ispinesib | KSP | Kinesin | 0.0263 | 0.0439 | 0.1261 | -0.9817 | -0.9567 | -0.8688 | -1.0000 | -0.9800 | -0.6258 | 0.4997 | 1.2912 | 3.1780 | 0.5293 | 0.6720 | 0.8104 | 0.0357 | 0.4315 | 1.3590 | |
| Taxol | TUBB | TUBB | 0.0078 | 0.0104 | 0.0155 | -0.5505 | -0.2204 | 0.0319 | -0.5168 | -0.1393 | 0.1113 | 1.6357 | 2.0915 | 3.1238 | 0.5399 | 0.6855 | 0.9358 | 0.0096 | 0.0111 | 0.0153 | |
| AG1024 | IGF1R | RTK | 14.2327 | 62.8199 | 100.0000 | 0.3069 | 0.5828 | 0.8614 | -0.0340 | 0.2904 | 0.6353 | 0.3280 | 1.4424 | 3.0172 | 0.0186 | 0.0785 | 0.1208 | 8.3409 | 30.1991 | 100.0000 | |
| ZM-447439 | AURK | AURK | 3.5193 | 19.1991 | 100.0000 | -0.0403 | 0.4141 | 0.5578 | -0.1176 | 0.3301 | 0.5652 | 0.5578 | 1.0337 | 2.9596 | 0.1428 | 0.2012 | 0.3024 | 0.6732 | 2.5837 | 16.4745 | |
| (Z)-4-Hydroxytamoxifen | ESR1 | N/A | 38.2142 | 72.1652 | 100.0000 | -0.2149 | 0.3051 | 0.6418 | -0.8145 | -0.0997 | 0.5442 | 0.6236 | 1.8012 | 2.9451 | 0.0928 | 0.1395 | 0.2253 | 17.7725 | 43.7586 | 100.0000 | |
| TCS 2312 | CHK1 | CHK | 0.3474 | 0.6156 | 0.9604 | -0.8358 | -0.6163 | -0.3941 | -0.8432 | -0.6104 | -0.3951 | 1.4081 | 2.0751 | 2.9131 | 0.3572 | 0.4368 | 0.5565 | 0.6031 | 1.0589 | 1.5099 | |
| Fascaplysin | CDK4 | CDK | 0.1734 | 0.2805 | 0.3987 | -0.9809 | -0.9546 | -0.8701 | -0.9898 | -0.9538 | -0.8570 | 1.9348 | 2.3235 | 2.8230 | 0.5843 | 0.6643 | 0.7626 | 0.3281 | 0.4110 | 0.6267 | |
| Nelfinavir | N/A | N/A | 8.4034 | 9.7440 | 15.4339 | -0.8211 | -0.6445 | -0.2989 | -1.0000 | -1.0000 | -0.8006 | 1.6805 | 2.3548 | 2.7767 | 0.1130 | 0.1589 | 0.1970 | 12.4011 | 15.3815 | 22.7642 | |
| Bortezomib | Proteasome | Proteasome | 0.0169 | 0.0283 | 0.0758 | -0.9074 | -0.8026 | -0.7299 | -0.9162 | -0.8011 | -0.7357 | 1.1703 | 1.8347 | 2.7508 | 0.9093 | 1.0406 | 1.1781 | 0.0266 | 0.0496 | 0.1485 | |
| AS-252424 | PI3K | PI3K | 19.5544 | 36.2256 | 100.0000 | 0.2865 | 0.4240 | 0.5918 | -0.9991 | 0.2157 | 0.5619 | 0.3148 | 0.6846 | 2.7243 | 0.0770 | 0.1059 | 0.1601 | 6.6689 | 89.5846 | 100.0000 | |
| AG1478 | EGFR | ErbB | 8.7673 | 51.6075 | 100.0000 | -0.0710 | 0.2684 | 0.6341 | -0.3109 | -0.0273 | 0.4206 | 0.8939 | 1.7205 | 2.6373 | 0.0902 | 0.1531 | 0.2936 | 3.7212 | 36.6666 | 94.4655 | |
| Gemcitabine | DNA replication | DNA replication | 0.0255 | 0.1767 | 1.3221 | -0.1534 | 0.1060 | 0.2747 | -0.1430 | 0.1441 | 0.3026 | 0.5558 | 1.2204 | 2.6334 | 0.3723 | 0.5392 | 0.7460 | 0.0153 | 0.0741 | 0.2614 | |
| Nutlin 3a | MDM2 | MDM2 | 15.2348 | 24.3890 | 41.8634 | -0.3252 | -0.0482 | 0.2155 | -1.0000 | -0.8163 | -0.2697 | 1.1456 | 1.7429 | 2.5635 | 0.0828 | 0.1397 | 0.2099 | 23.6810 | 39.7952 | 62.9892 | |
| Gefitinib | EGFR | ErbB | 6.6704 | 12.9191 | 28.3915 | -0.2671 | 0.0424 | 0.3018 | -0.8465 | -0.5620 | -0.2259 | 0.9170 | 1.3719 | 2.5436 | 0.0767 | 0.1382 | 0.2408 | 9.0805 | 26.2291 | 41.5832 | |
| Doxorubicin | TOP2 | TOP | 0.1488 | 0.2099 | 0.7023 | -0.9456 | -0.8552 | -0.5483 | -0.8723 | -0.7083 | -0.3772 | 1.0561 | 1.4782 | 2.5260 | 0.5209 | 0.6697 | 0.8073 | 0.2444 | 0.4713 | 1.2126 | |
| SB-3CT | MMP2/9 | MMP | 69.9094 | 100.0000 | 100.0000 | 0.4441 | 0.6795 | 0.8316 | -0.1049 | 0.6210 | 0.7846 | 0.0670 | 0.6905 | 2.4960 | 0.0290 | 0.0754 | 0.1306 | 27.8608 | 93.1362 | 100.0000 | |
| Docetaxel | TUBB | TUBB | 0.0022 | 0.0051 | 0.0098 | -0.3944 | -0.0464 | 0.1697 | -0.4257 | -0.0477 | 0.1373 | 1.4024 | 1.6746 | 2.3040 | 0.4979 | 0.6215 | 0.8198 | 0.0027 | 0.0049 | 0.0080 | |
| TPCA-1 | IKK | NFKB | 4.9121 | 23.5816 | 100.0000 | 0.0988 | 0.4346 | 0.6277 | -0.1071 | 0.3912 | 0.5674 | 0.5796 | 1.2158 | 2.2892 | 0.0966 | 0.1616 | 0.2244 | 2.5700 | 5.7466 | 43.2238 | |
| Trichostatin A | HDAC | HDAC | 6.5374 | 11.5225 | 17.5553 | -0.9202 | -0.8512 | -0.7541 | -0.9053 | -0.8178 | -0.6756 | 1.3647 | 1.8955 | 2.2777 | 0.6490 | 0.7724 | 0.9158 | 11.0302 | 20.2024 | 30.2620 | |
| Cisplatin | DNA cross-linker | DNA cross-linker | 4.4823 | 11.6380 | 25.2438 | -0.8850 | -0.6449 | -0.2565 | -0.9047 | -0.5931 | -0.2921 | 1.0217 | 1.3698 | 2.2177 | 0.2715 | 0.3752 | 0.4391 | 8.7984 | 21.1543 | 38.4325 | |
| LBH589 | HDAC | HDAC | 0.0792 | 0.1432 | 0.2719 | -0.9159 | -0.8072 | -0.7128 | -0.9155 | -0.7955 | -0.6832 | 1.1720 | 1.5004 | 2.1649 | 0.5471 | 0.6739 | 0.7846 | 0.1472 | 0.2600 | 0.4626 | |
| Carboplatin | DNA cross-linker | DNA cross-linker | 30.4522 | 52.4276 | 91.0569 | -0.9081 | -0.7672 | -0.5844 | -0.9460 | -0.8644 | -0.7390 | 1.2433 | 1.6402 | 2.1619 | 0.2714 | 0.3706 | 0.4859 | 52.1319 | 91.7409 | 100.0000 | |
| Epirubicin | TOP2 | TOP | 0.2120 | 0.3019 | 0.4930 | -0.9915 | -0.9463 | -0.8152 | -0.8492 | -0.7437 | -0.6556 | 0.9325 | 1.4047 | 2.1457 | 0.6134 | 0.7438 | 0.8467 | 0.3985 | 0.6015 | 1.3650 | |
| Glycyl-H-1152 | ROCK2 | N/A | 7.8389 | 29.5632 | 100.0000 | 0.0725 | 0.4318 | 0.6407 | -0.4259 | 0.0666 | 0.6245 | 0.3449 | 0.9010 | 2.0476 | 0.0704 | 0.1476 | 0.1891 | 2.5420 | 16.8696 | 100.0000 | |
| Sigma A6730 | AKT | AKT | 2.0327 | 6.5660 | 11.2198 | -0.9178 | -0.8320 | -0.6777 | -1.0000 | -1.0000 | -0.9546 | 0.9310 | 1.3794 | 2.0044 | 0.2439 | 0.2875 | 0.4042 | 6.3004 | 13.6236 | 19.0461 |