Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MB 157
Unknown
Unknown
 Etoposide
TOP2
TOP
7482.074
uM
0.18831
0.56350
 -0.8009 -0.6662 0.7727 0.8202
0.9535
 1.7663
MB 157
Unknown
Unknown
 AS-252424
PI3K
PI3K
12580.165
uM
inf
inf
 0.9815 0.9815 0.0000 0.0012
0.1111
 2.2883
MB 157
Unknown
Unknown
 CPT-11
TOP1
TOP
9039.078
uM
3.48660
7.04560
 -0.9875 -1.0000 1.5617 0.3981
0.9915
 0.6306
MB 157
Unknown
Unknown
 AG1478
EGFR
ErbB
9039.016
uM
inf
inf
 -0.3711 -0.3711 0.0000 0.3841
0.5565
 0.5468
MB 157
Unknown
Unknown
 Vorinostat
HDAC
HDAC
7482.065
uM
103.49220
292.37470
 -0.7311 -0.7760 0.9021 0.5820
0.9995
 2.2390
MB 157
Unknown
Unknown
 Ispinesib
KSP
Kinesin
7482.067
uM
0.01035
0.01271
 -0.9081 -0.7477 4.4646 1.0951
0.9672
 1.9350
MB 157
Unknown
Unknown
 Bosutinib
Src
nRTK
12580.17
uM
0.23378
0.96284
 -0.6288 -0.8257 0.6889 0.5094
0.9755
 1.9993
MB 157
Unknown
Unknown
 Afatinib
EGFR/HER2
ErbB
12580.165
uM
0.02446
0.53837
 -0.7389 -1.0000 0.3553 0.7931
0.9550
 2.2883
MB 157
Unknown
Unknown
 (Z)-4-Hydroxytamoxifen
ESR1
9039.016
uM
56.67380
1000.00000
 0.2424 -0.8928 0.3569 0.1994
0.6376
 0.5468
MB 157
Unknown
Unknown
 Pevonedistat
NAE1
NAE1
12580.135
uM
0.30216
0.24681
 0.1102 0.1338 1.5384 0.3784
0.9967
 2.1782
MB 157
Unknown
Unknown
 Fascaplysin
CDK4
CDK
7482.084
uM
0.12446
0.15235
 -0.9397 -0.8743 5.0000 0.7825
0.9980
 1.8697
MB 157
Unknown
Unknown
 5-DFUR
TYMS
TYMS
12580.143
uM
10.78580
8.72060
 0.0852 0.2270 2.8463 0.3694
0.9745
 2.2318
MB 157
Unknown
Unknown
 Dactolisib
PI3K
PI3K
12580.155
uM
0.15405
0.11476
 0.2968 0.2441 2.2754 0.3494
0.9739
 2.2315
MB 157
Unknown
Unknown
 JNK-IN-5A
JNK
JNK
12580.168
uM
140.86720
212.72740
 0.1400 -0.8586 2.4251 0.1014
0.9615
 2.0973
MB 157
Unknown
Unknown
 Gefitinib
EGFR
ErbB
9039.016
uM
3.54030
10.82390
 -0.5859 -1.0000 0.9831 0.3413
0.8529
 0.5468
MB 157
Unknown
Unknown
 Doxorubicin
TOP2
TOP
9039.078
uM
0.07987
0.15879
 -1.0000 -1.0000 1.5989 1.0364
0.9906
 0.6306
MB 157
Unknown
Unknown
 Erlotinib
EGFR
ErbB
7482.091
uM
0.1180
1.89770
 -0.3261 -0.6655 0.3047 0.5539
0.9073
 1.9368
MB 157
Unknown
Unknown
 Imatinib
ABL/KIT/PDGFR
nRTK
7482.091
uM
21.96750
32.89250
 -0.9235 -0.9157 2.5782 0.4301
0.9918
 1.9368
MB 157
Unknown
Unknown
 FTase Inhibitor I
Ftase
MAPK
12580.167
uM
inf
inf
 1.0233 1.0233 0.0000 -0.0124
-0.4459
 2.1970
MB 157
Unknown
Unknown
 Glycyl-H-1152
ROCK2
12580.169
uM
2.21430
2.9020
 -0.2656 -0.2333 1.4159 0.2752
0.9908
 2.1524
MB 157
Unknown
Unknown
 Triciribine
AKT
AKT
7482.074
uM
2.67840
317.77670
 0.2035 -1.0000 0.2300 0.2827
0.6689
 1.7663
MB 157
Unknown
Unknown
 Sirolimus
MTOR
MTOR
7482.069
uM
inf
0.02594
 0.7163 0.7222 1.5641 0.1554
0.9762
 2.1744
MB 157
Unknown
Unknown
 Nutlin 3a
MDM2
MDM2
7482.066
uM
19.4010
19.74440
 -0.0414 -0.0443 4.8390 0.0474
0.9858
 1.1347
MB 157
Unknown
Unknown
 L-779450
BRAF
MAPK
12580.166
uM
10.15030
9.16750
 0.1997 0.1984 4.9629 0.0310
0.9777
 1.8686
MB 157
Unknown
Unknown
 Lapatinib
EGFR/HER2
ErbB
7482.098
uM
inf
0.84860
 0.5818 0.5588 1.3649 0.1246
0.9576
 2.2478