Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Antibody	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184B5	NM	Basal	Dichloroacetate		PDK	PDK	12979.176	uM	inf	0.01220	0.9086	0.8652	4.8576	0.0350	0.7045	1.0091
184A1	NM	Basal	MG-132		Proteasome	Proteasome	12509.17	uM	0.02024	0.05106	-0.8085	-0.6493	0.8994	0.9276	0.9449	1.3955
184B5	NM	Basal	Dactolisib		PI3K	PI3K	12566.155	uM	0.10180	0.09596	0.1073	0.1279	4.9998	0.4116	0.9754	1.5389
184A1	NM	Basal	Everolimus		MTOR	MTOR	12509.164	uM	0.02317	2.80470	-0.9610	-1.0000	0.2291	0.6861	0.6516	1.1949
184B5	NM	Basal	CPT-11		TOP1	TOP	9095.121	uM	2.51920	28.77490	-0.2643	-0.9655	0.4415	0.3101	0.9565	1.1992
184A1	NM	Basal	Methotrexate		DHFR	Metabolism	5895.085	uM	0.05117	0.05935	-0.3071	-0.3193	3.3302	0.8875	0.9988	1.4396
184B5	NM	Basal	Cisplatin		DNA cross-linker	DNA cross-linker	9095.049	uM	inf	193.58440	0.7160	0.7080	3.7384	0.0137	0.8937	1.1202
184B5	NM	Basal	Chloroquine				12979.177	uM	19.64650	24.47430	-1.0000	-1.0000	5.0000	0.1512	0.9526	0.5647
184A1	NM	Basal	Methotrexate		DHFR	Metabolism	5894.084	uM	0.05840	0.06456	-0.2992	-0.3127	4.8467	0.9024	0.9966	1.5903
184B5	NM	Basal	CGC-11047		Polyamine analogue		9095.026	uM	486.65450	602.90190	-0.9562	-0.9592	5.0000	0.3089	0.9969	1.0168
184A1	NM	Basal	Etoposide		TOP2	TOP	5895.074	uM	10.48650	42.19930	-0.7395	-1.0000	0.7891	0.3710	0.9859	1.1218
184B5	NM	Basal		Cetuximab	EGFR	ErbB	9095.026	uM	0.04089	0.03186	0.1205	0.1008	0.9024	0.1873	0.9743	1.0168
184A1	NM	Basal	Mebendazole				12684.174	uM	inf	0.36667	0.5334	0.5745	5.0000	0.1723	0.9699	1.4645
184B5	NM	Basal	Carboplatin		DNA cross-linker	DNA cross-linker	9095.119	uM	5.77830	14.25320	-0.9033	-0.9300	1.1638	0.6853	0.9882	1.2263
184A1	NM	Basal		Cetuximab	EGFR	ErbB	9047.026	uM	0.00360	0.01403	-0.2605	-0.4617	0.4805	0.4918	0.8777	0.5972
184B5	NM	Basal	Bromopyruvic acid		Hexokinase II	Metabolism	12979.177	uM	0.02740	0.03413	-1.0000	-1.0000	5.0000	1.0789	0.9988	0.5647
184A1	NM	Basal	Baicalein		Lipoxygenase	Metabolism	5895.073	uM	inf	35.38250	0.5990	0.5817	2.0246	0.0235	0.9408	1.4431
184A1	NM	Basal	Lestaurtinib		FLT3/JAK2/TrkA	RTK	12509.167	uM	1.46780	2.26520	-0.8669	-0.8656	2.3156	0.3809	0.9959	1.4256
184B5	NM	Basal	Bosutinib		Src	nRTK	12566.17	uM	0.54836	0.85384	-0.2865	-0.3368	1.1630	0.4044	0.9933	1.4648
184A1	NM	Basal	Etoposide		TOP2	TOP	5894.074	uM	9.28560	35.69030	-0.7680	-1.0000	0.8160	0.4044	0.9826	1.4541
184A1	NM	Basal	(Z)-4-Hydroxytamoxifen		ESR1		9047.132	uM	inf	inf	0.4055	0.4055	0.0000	0.2074	0.3073	0.6985
184B5	NM	Basal	Bortezomib		Proteasome	Proteasome	5896.074	uM	0.01517	0.03188	-0.7992	-0.7384	1.2208	1.1454	0.9925	1.4124
184A1	NM	Basal	LBH589		HDAC	HDAC	12509.167	uM	0.29923	0.89089	-0.7415	-0.8021	0.8773	0.4884	0.9905	1.4256
184B5	NM	Basal	Bortezomib		Proteasome	Proteasome	5896.074	uM	0.01517	0.03188	-0.7992	-0.7384	1.2208	1.1454	0.9925	1.4124
184A1	NM	Basal	17-AAG		HSP90	HSP90	9047.037	uM	0.00930	0.01282	-0.9826	-0.6989	2.7212	1.1760	0.9539	0.5262

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Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)