Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184B5	NM	Basal	FR180204	ERK1/2	MAPK	12566.166	uM	12.86090	9.57870	0.2046	0.1774	1.4873	0.1461	0.9905	1.2010
184A1	NM	Basal	NU6102	CDK1/2	CDK	12509.147	uM	6.59190	12.95280	-0.8721	-1.0000	1.6264	0.2474	0.9935	1.2058
184B5	NM	Basal	Fascaplysin	CDK4	CDK	5896.084	uM	0.23326	0.34203	-0.9161	-0.9115	2.7115	0.6772	0.9996	1.5200
184A1	NM	Basal	FR180204	ERK1/2	MAPK	12509.166	uM	30.45440	25.56580	0.2919	0.2912	4.9895	0.0565	0.9495	1.2847
184B5	NM	Basal	Fascaplysin	CDK4	CDK	5897.085	uM	0.32680	0.48798	-0.9650	-0.9672	2.6852	0.6599	0.9981	1.2392
184A1	NM	Basal	NSC 663284	CDC25	CDC	12509.152	uM	1.61730	2.02890	-0.9303	-0.9290	4.6320	0.6528	0.9971	1.3755
184B5	NM	Basal	Everolimus	MTOR	MTOR	12566.164	uM	3.63690	995.7980	0.2684	-0.8205	0.1730	0.3513	0.8480	1.5173
184A1	NM	Basal	CGC-11047	Polyamine analogue		9047.026	uM	5.67110	70.62780	-0.9997	-1.0000	0.4356	0.7516	0.8174	0.5972
184B5	NM	Basal	Etoposide	TOP2	TOP	5897.074	uM	20.40170	44.09240	-0.1173	-0.3858	0.7421	0.2819	0.9802	1.2824
184A1	NM	Basal	Bortezomib	Proteasome	Proteasome	5895.074	uM	0.02162	0.11251	-0.8342	-0.8244	0.5906	1.0107	0.9534	1.1218
184A1	NM	Basal	Nilotinib	ABL	nRTK	12509.17	uM	inf	0.16976	0.8260	0.8615	1.0340	0.0781	0.8007	1.3955
184B5	NM	Basal	Etoposide	TOP2	TOP	5896.074	uM	4.08810	48.86320	-0.4513	-1.0000	0.4428	0.4398	0.9738	1.4124
184A1	NM	Basal	Fascaplysin	CDK4	CDK	5894.084	uM	0.44564	0.69098	-0.9438	-0.9392	2.4104	0.5734	0.9993	1.5903
184A1	NM	Basal	Afatinib	EGFR/HER2	ErbB	12509.165	uM	0.02251	0.33740	-0.9088	-1.0000	0.4058	0.8284	0.9307	1.5022
184B5	NM	Basal	Erlotinib	EGFR	ErbB	5897.091	uM	1.28840	1.31750	0.0348	-0.0092	0.8129	0.3029	0.9812	1.2296
184A1	NM	Basal	Nelfinavir			12684.174	uM	3.030	4.22870	-0.6445	-0.6543	2.5101	0.2990	0.9857	1.4645
184B5	NM	Basal	Erlotinib	EGFR	ErbB	5896.091	uM	0.19497	0.13149	0.0999	0.1474	0.8866	0.4253	0.9753	1.4988
184B5	NM	Basal	Doxorubicin	TOP2	TOP	9095.121	uM	0.11890	0.22542	-0.9889	-0.9914	1.7083	0.9694	0.9884	1.1992
184A1	NM	Basal	Pevonedistat	NAE1	NAE1	12509.135	uM	0.63324	0.71207	-0.0395	-0.0415	0.6794	0.3594	0.9880	1.3717
184B5	NM	Basal	Docetaxel	TUBB	TUBB	9095.002	uM	0.00444	0.00218	0.4170	0.3901	2.1393	0.3930	0.9566	1.0607
184A1	NM	Basal	Fascaplysin	CDK4	CDK	5895.085	uM	0.34845	0.59708	-0.9460	-0.9541	1.9822	0.6207	0.9980	1.4396
184B5	NM	Basal	Docetaxel	TUBB	TUBB	12979.002	uM	inf	inf	0.7220	0.7220	0.0000	0.1667	0.1607	1.3178
184A1	NM	Basal	MG-132	Proteasome	Proteasome	12509.17	uM	0.02024	0.05106	-0.8085	-0.6493	0.8994	0.9276	0.9449	1.3955
184B5	NM	Basal	Disulfiram	Proteasome	Proteasome	12979.174	uM	13.46160	19.5890	-0.9600	-1.0000	2.9286	0.2119	0.9801	1.5680
184A1	NM	Basal	CGC-11047	Polyamine analogue		10002.034	uM	242.78660	399.08510	-0.9907	-1.0000	2.2105	0.6269	0.7996	0.6736

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)