Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 12003.157 | uM | 1.19460 | 1.16540 | -0.0272 | 0.0582 | 5.0000 | 0.4365 | 0.8615 | 1.0729 | |
| MDA-MB-134-VI | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10519.139 | uM | 1.26790 | 1.37170 | -0.0861 | -0.0865 | 2.0272 | 0.4160 | 0.9889 | 1.0177 | |
| SUM159PT | TNBC | Basal B | XRP44X | ELK3 | MAPK | 10520.139 | uM | 0.65397 | 0.97317 | -0.7104 | -0.4568 | 1.6327 | 0.5670 | 0.9512 | 3.6491 | |
| HCC1143 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 12112.157 | uM | 11.75790 | 0.56131 | 0.5118 | 0.4877 | 1.2188 | 0.2507 | 0.7951 | 2.0505 | |
| SUM225CWN | HER2amp | Basal A | XRP44X | ELK3 | MAPK | 10579.139 | uM | 2.020 | 1.80530 | 0.1277 | 0.1416 | 2.9630 | 0.3124 | 0.9786 | 1.1260 | |
| MDA-MB-134-VI | HR+ | Luminal | XRP44X | ELK3 | MAPK | 12206.157 | uM | 0.76755 | 1.04930 | -0.3319 | -0.3141 | 1.5590 | 0.5114 | 0.9889 | 0.9766 | |
| ZR-75-1 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11660.151 | uM | 1.15050 | 1.05550 | 0.1402 | 0.1749 | 4.9958 | 0.3806 | 0.8954 | 0.9483 | |
| HCC1954 | HER2amp | Basal A | XRP44X | ELK3 | MAPK | 11055.151 | uM | 0.41139 | 0.48892 | -0.3275 | -0.2602 | 2.4266 | 0.5925 | 0.9720 | 1.8913 | |
| T47DKBLUC | Unknown | Unknown | XRP44X | ELK3 | MAPK | 12608.171 | uM | 1.87240 | 1.88460 | 0.0214 | -0.0164 | 5.0000 | 0.3781 | 0.9604 | 1.0643 | |
| BT-483 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11855.157 | uM | 67.55370 | 996.11240 | 0.4977 | -0.2530 | 0.1522 | 0.2936 | 0.8392 | 0.7986 | |
| SUM149PT | TNBC | Basal B | XRP44X | ELK3 | MAPK | 11937.157 | uM | 1.5510 | 1.36920 | 0.3468 | 0.2320 | 5.0000 | 0.2711 | 0.9294 | 2.4025 | |
| BT-483 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10696.151 | uM | 0.22604 | 2.12580 | -0.8574 | -1.0000 | 0.4902 | 0.6822 | 0.9097 | 0.3690 | |
| SUM185PE | TNBC | Luminal | XRP44X | ELK3 | MAPK | 12269.157 | uM | 0.01870 | 0.01625 | 0.1418 | 0.2521 | 4.9999 | 0.4915 | 0.6464 | 0.5397 | |
| HCC1419 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 12001.157 | uM | 595.7630 | 6.75410 | 0.4856 | 0.3021 | 0.2069 | 0.2488 | 0.5802 | 0.5904 | |
| SUM225CWN | HER2amp | Basal A | XRP44X | ELK3 | MAPK | 12098.157 | uM | inf | 1.40390 | 0.3594 | 0.5068 | 4.9916 | 0.1832 | 0.8708 | 1.3067 | |
| AU565 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 10880.151 | uM | 0.36637 | 0.46911 | -0.5707 | -0.5373 | 2.9523 | 0.6965 | 0.9922 | 1.8509 | |
| ZR75B | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11939.157 | uM | 1.36460 | 1.02480 | 0.2317 | 0.2281 | 2.1272 | 0.3166 | 0.9749 | 1.5908 | |
| 600MPE | HR+ | Luminal | XRP44X | ELK3 | MAPK | 12224.157 | uM | inf | 0.72241 | 0.7069 | 0.6798 | 1.3565 | 0.1569 | 0.6341 | 1.0737 | |
| SUM229PE | TNBC | - | XRP44X | ELK3 | MAPK | 11058.151 | uM | 0.30521 | 0.26513 | 0.2427 | 0.2527 | 5.0000 | 0.3693 | 0.9784 | 2.2617 | |
| SK-BR-3 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 11851.157 | uM | 1.89760 | 1.88790 | -0.0293 | 0.0127 | 5.0000 | 0.3580 | 0.9733 | 1.4707 | |
| SUM159PT | TNBC | Basal B | XRP44X | ELK3 | MAPK | 11057.151 | uM | 0.93403 | 0.78279 | 0.1565 | 0.2344 | 3.5803 | 0.3103 | 0.9477 | 4.1698 | |
| MB 157 | Unknown | Unknown | XRP44X | ELK3 | MAPK | 12580.171 | uM | 1.35870 | 1.36780 | -0.0074 | -0.0072 | 2.1297 | 0.3610 | 0.9996 | 2.0272 | |
| SUM52PE | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11852.157 | uM | 0.80427 | 0.96504 | -0.2191 | -0.2240 | 2.0313 | 0.4927 | 0.9840 | 1.4174 | |
| MDA-MB-134-VI | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10998.151 | uM | 0.59196 | 0.63270 | 0.0499 | -0.0948 | 2.6094 | 0.4574 | 0.9332 | 0.6986 | |
| UACC-812 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 10754.151 | uM | 0.58907 | 0.61969 | -0.0227 | -0.0463 | 1.7464 | 0.4735 | 0.9617 | 0.9579 |