Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Chloroquine | 12702.177 | uM | 5.96530 | 9.57550 | -0.6177 | -0.6675 | 1.7918 | 0.2519 | 0.9986 | 1.5730 | |||
| HCC1954 | HER2amp | Basal A | Methylglyoxal | 13631.184 | uM | inf | inf | -0.9647 | -0.9647 | 0.0000 | 0.6967 | 0.4015 | 1.3577 | |||
| EFM-192A | HER2amp | Luminal | Ribavirin | 15284.211 | uM | 73.29440 | 62.64580 | 0.8208 | 0.2710 | 4.9741 | 0.0019 | 0.6080 | 0.8976 | |||
| Hs 578T | TNBC | Basal B | Chloroquine | 12622.177 | uM | 5.16760 | 8.74240 | -0.6678 | -0.7210 | 1.6981 | 0.2810 | 0.9997 | 2.5433 | |||
| HCC1806 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 12239.16 | uM | inf | 8.170 | 0.6981 | 0.6893 | 1.6228 | 0.0296 | 0.9372 | 1.8654 | ||
| SUM1315MO2 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9797.006 | uM | 240.24350 | 316.40620 | -1.0000 | -1.0000 | 3.9895 | 0.5345 | 0.9201 | 0.4196 | ||
| SUM1315MO2 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 10139.034 | uM | 747.5240 | 1000.00000 | -0.9445 | -0.7365 | 3.1115 | 0.2590 | 0.8815 | 0.8381 | ||
| MCF 10A | NM | Basal B | Methylglyoxal | 13551.184 | uM | 680.90370 | 999.99950 | -0.2926 | -0.2104 | 0.9138 | 0.3902 | 0.9470 | 3.0171 | |||
| MCF 10A | NM | Basal B | CGC-11047 | Polyamine analogue | 7870.018 | uM | 265.4420 | 530.97710 | -0.7548 | -0.8469 | 1.4293 | 0.4668 | 0.8849 | 2.2478 | ||
| SUM159PT | TNBC | Basal B | Torkinib | 15402.211 | uM | 0.01202 | 0.01610 | -0.0537 | -0.0724 | 0.4628 | 0.6556 | 0.9950 | 3.0887 | |||
| MCF7 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7875.016 | uM | 36.8150 | 155.18220 | -0.0965 | -1.0000 | 0.7636 | 0.1967 | 0.9078 | 1.6229 | ||
| MDA-MB-157 | TNBC | Basal B | Methylglyoxal | 13611.184 | uM | 444.34060 | 663.74310 | -0.9810 | -0.8867 | 2.5419 | 0.7713 | 0.9453 | 0.8419 | |||
| MCF 10A | NM | Basal B | Mebendazole | 12944.174 | uM | 5.09360 | 7.17890 | -0.0457 | -0.1840 | 0.9131 | 0.2211 | 0.9985 | 2.7985 | |||
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7871.016 | uM | inf | 34.66260 | 0.8429 | 0.8429 | 4.9988 | -0.0104 | 0.6376 | 1.0272 | ||
| MDA-MB-157 | TNBC | Basal B | Nelfinavir | 12632.174 | uM | 8.66770 | 10.84610 | -0.9889 | -0.9971 | 4.8914 | 0.1686 | 0.9955 | 0.8563 | |||
| HCC2185 | TNBC | Luminal | TAPI-0 | TACE/Collagenase | 7462.096 | uM | 0.31064 | 0.30734 | -0.0269 | 0.0260 | 5.0000 | 0.3485 | 0.9689 | 0.3514 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7863.018 | uM | 93.13020 | 1000.00000 | -0.7605 | -0.9551 | 0.4500 | 0.3964 | 0.6501 | 2.0946 | ||
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7872.016 | uM | 7.35710 | 5.64830 | 0.1459 | 0.2589 | 2.7594 | 0.2512 | 0.8956 | 1.4834 | ||
| HCC38 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9028.016 | uM | inf | 0.64162 | 0.7236 | 0.7617 | 4.7985 | 0.0777 | 0.8803 | 1.2348 | ||
| MCF7 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7874.016 | uM | inf | 7.93870 | 0.5977 | 0.4146 | 0.2796 | 0.1875 | 0.9565 | 1.5947 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 10266.026 | uM | 105.61670 | 682.00580 | -0.8390 | -1.0000 | 0.5890 | 0.4418 | 0.8587 | 0.6682 | ||
| HCC38 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7854.016 | uM | inf | 7.23080 | 0.3700 | 0.5045 | 5.0000 | 0.1340 | 0.8222 | 0.9074 | ||
| HCC38 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9453.019 | uM | 50.39440 | 91.7690 | -0.5042 | -1.0000 | 1.8329 | 0.1656 | 0.9890 | 1.1486 | ||
| MCF7 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9583.132 | uM | inf | inf | 0.9409 | 0.9409 | 0.0000 | 0.0291 | 0.4029 | 1.2070 | ||
| MCF 10A | NM | Basal B | CGC-11047 | Polyamine analogue | 9551.026 | uM | 185.91980 | 1000.00000 | -0.6377 | -0.8853 | 0.6057 | 0.3813 | 0.7752 | 2.6508 |