Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7805.018 | uM | 422.43070 | 1000.00000 | -0.9572 | -0.9395 | 1.2271 | 0.4304 | 0.6619 | 1.1451 | ||
| SUM1315MO2 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7529.016 | uM | inf | inf | 0.8150 | 0.8150 | 0.0000 | 0.0987 | 0.4662 | 0.5847 | ||
| CAMA-1 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9210.026 | uM | 847.57060 | 1000.00000 | -0.9180 | -0.6431 | 4.9999 | 0.2844 | 0.7794 | 0.9102 | ||
| CAMA-1 | HR+ | Luminal | Chloroquine | 12647.177 | uM | 12.40710 | 17.97030 | -0.9748 | -1.0000 | 2.9656 | 0.2853 | 0.9653 | 1.0387 | |||
| HCC1569 | HER2amp | Basal A | Pertuzumab | 7447.102 | mg/ml | inf | 124.99960 | 0.8861 | 0.6968 | 0.1346 | 0.0581 | 0.6369 | 1.6467 | |||
| SUM159PT | TNBC | Basal B | Nelfinavir | 13054.174 | uM | inf | inf | 0.9613 | 0.9613 | 0.0000 | 0.0251 | 0.1450 | 3.1161 | |||
| SUM159PT | TNBC | Basal B | Nelfinavir | 13004.174 | uM | 9.96910 | 15.89760 | -0.7031 | -1.0000 | 2.3541 | 0.1857 | 0.9862 | 3.2757 | |||
| MCF 10A | NM | Basal B | CGC-11047 | Polyamine analogue | 7868.018 | uM | 166.63690 | 683.31190 | -0.7886 | -1.0000 | 0.7785 | 0.4292 | 0.9325 | 2.1110 | ||
| MCF12A | NM | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7873.016 | uM | 14.21690 | 20.24340 | -0.8431 | -0.8481 | 2.8065 | 0.3039 | 0.9986 | 2.1516 | ||
| BT-20 | TNBC | Basal A | Nelfinavir | 13579.174 | uM | 6.73570 | 8.99950 | -0.9951 | -1.0000 | 3.7916 | 0.2274 | 0.9935 | 0.8018 | |||
| HCC1569 | HER2amp | Basal A | Ribavirin | 15388.211 | uM | inf | inf | 0.9655 | 0.9655 | 0.0000 | 0.0072 | -0.0182 | 1.5247 | |||
| LY2 | HR+ | Luminal | Nelfinavir | 12627.174 | uM | 8.39840 | 12.76790 | -0.8520 | -1.0000 | 2.6227 | 0.1651 | 0.9984 | 1.3419 | |||
| HCC70 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7856.018 | uM | 3.24150 | 49.7860 | -0.9805 | -1.0000 | 0.4022 | 0.7437 | 0.8488 | 0.9388 | ||
| 600MPE | HR+ | Luminal | Ibandronate | FDPS | 12224.143 | uM | 126.68820 | 145.52130 | -0.4151 | -0.4152 | 4.3619 | 0.2882 | 0.9949 | 0.8349 | ||
| MDA-MB-436 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7898.016 | uM | 29.22070 | 36.11050 | -0.9401 | -0.9411 | 5.0000 | 0.2132 | 0.9955 | 1.2127 | ||
| MDA-MB-436 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7902.016 | uM | inf | inf | 0.4502 | 0.4502 | 0.0000 | 0.1492 | 0.4514 | 1.9004 | ||
| MX1 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 10874.15 | uM | 0.88473 | 3.17410 | -0.7532 | -1.0000 | 0.8600 | 0.4557 | 0.9604 | 0.9133 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9158.123 | uM | 3.16810 | 8.29940 | -0.9937 | -1.0000 | 1.1408 | 0.4810 | 0.9711 | 0.8769 | ||
| HCC1569 | HER2amp | Basal A | Torkinib | 15388.211 | uM | 0.00154 | 0.18585 | -0.5621 | -1.0000 | 0.2292 | 0.9195 | 0.9903 | 1.5247 | |||
| MDA-MB-157 | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 12594.169 | uM | 93.8070 | 79.06540 | 0.7849 | 0.2856 | 4.9526 | -0.0037 | 0.6954 | 1.4097 | ||
| EFM-192B | HER2amp | Luminal | Ribavirin | 15288.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0002 | -0.0013 | 0.9250 | |||
| MDA-MB-157 | TNBC | Basal B | Ibandronate | FDPS | 12594.143 | uM | 41.30360 | 85.96350 | -0.9494 | -0.9455 | 1.4483 | 0.4126 | 0.9949 | 1.2787 | ||
| MCF7 | HR+ | Luminal | Ribavirin | 15394.211 | uM | inf | 11.26250 | 0.5083 | 0.5081 | 4.9999 | 0.0487 | 0.9495 | 1.8299 | |||
| BT-474 | HER2amp | Luminal | Chloroquine | 13125.177 | uM | 16.18740 | 20.98530 | -0.9865 | -1.0000 | 4.2322 | 0.2522 | 0.8943 | 0.8991 | |||
| CAMA-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10755.15 | uM | inf | inf | 0.4395 | 0.4395 | 0.0000 | 0.2504 | 0.3664 | 0.7807 |