Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 7898.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0820 | 0.0614 | 0.7130 | |
| MCF 10F | NM | - | PS-1145 | IKK | NFKB | 7486.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0198 | -0.3050 | 1.1517 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 10643.139 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6402 | |
| MDA-MB-415 | HR+ | Luminal | PD184352 | MEK | MAPK | 10938.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0131 | -0.0082 | 0.5336 | |
| EFM-192B | HER2amp | Luminal | Ribavirin | 15387.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0048 | -0.0190 | 1.2404 | |||
| EFM-192B | HER2amp | Luminal | Ribavirin | 15288.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0002 | -0.0013 | 0.9250 | |||
| Hs 578T | TNBC | Basal B | PS-1145 | IKK | NFKB | 7472.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0360 | -1.1311 | 0.9830 | |
| HCC1937 | TNBC | Basal A | Nilotinib | ABL | nRTK | 11849.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0324 | 0.0000 | 1.5253 | |
| LY2 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12319.135 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3806 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5899.094 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0167 | -0.1754 | 1.0334 | |
| BT-20 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 5903.102 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0171 | -0.1575 | 1.2557 | |
| MDA-MB-361 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 12379.168 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.4672 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 7898.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0820 | 0.0614 | 0.7130 | |
| CAMA-1 | HR+ | Luminal | Ribavirin | 15348.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0410 | -5.7835 | 0.7490 | |||
| HCC70 | TNBC | Basal A | Nilotinib | ABL | nRTK | 12400.17 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0014 | -0.0040 | 1.1992 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7475.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 2.6839 | |
| Hs 578T | TNBC | Basal B | Triciribine | AKT | AKT | 7473.074 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0187 | -0.0877 | 2.5364 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7450.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.7844 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7474.09 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0177 | -0.3118 | 2.4405 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 7898.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.7130 | |
| SUM1315MO2 | TNBC | Basal B | Nilotinib | ABL | nRTK | 10875.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0427 | -3.3446 | 0.7643 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5904.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6537 | |
| MDA-MB-134-VI | HR+ | Luminal | Cetuximab | EGFR | ErbB | 10077.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3999 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7794.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.6812 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7528.071 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.5828 |