Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Triciribine | AKT | AKT | 7472.074 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0523 | -0.0595 | 1.5922 | |
| MDA-MB-134-VI | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7877.017 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.1618 | 0.3038 | 0.6955 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 5904.085 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0334 | -1.4110 | 1.2247 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 9028.05 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0399 | -2.6337 | 0.9299 | |
| CAMA-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7805.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0217 | -0.4906 | 1.1451 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10816.149 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.4545 | |
| MDA-MB-231 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7504.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0441 | -20.3886 | 1.6220 | |
| MDA-MB-361 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7506.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0433 | 0.1148 | 1.0475 | |
| Hs 578T | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7475.067 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0408 | -9.2547 | 2.4078 | |
| LY2 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7477.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0458 | -19.0433 | 1.1485 | |
| LY2 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7865.016 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0278 | 0.0148 | 1.8047 | ||
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7472.098 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0197 | -0.2479 | 1.5098 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7473.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 2.3297 | |
| MCF 10F | NM | - | FTase Inhibitor I | Ftase | MAPK | 12254.154 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0451 | -13.9008 | 1.6307 | |
| LY2 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7477.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.7891 | |
| HCC1806 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 7450.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0008 | 0.1356 | 1.0419 | |
| LY2 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7477.084 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0334 | -0.0852 | 0.9476 | |
| SUM185PE | TNBC | Luminal | Cetuximab | EGFR | ErbB | 10146.124 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.9296 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5902.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.0245 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 10385.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0010 | 0.0617 | 0.7986 | |
| SUM159PT | TNBC | Basal B | PS-1145 | IKK | NFKB | 7531.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0370 | -7.5867 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Ro 32-0432 | PKC | PKC | 10520.142 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0236 | -0.3274 | 3.1766 | |
| MDA-MB-231 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7504.084 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0371 | -3.9735 | 1.8866 | |
| SUM1315MO2 | TNBC | Basal B | Nilotinib | ABL | nRTK | 12428.17 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0450 | -2.6385 | 0.9724 | |
| Hs 578T | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7472.072 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.2269 |