Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7456.067 | uM | 0.02697 | 0.03224 | -0.8657 | -0.7198 | 5.0000 | 0.9493 | 0.9949 | 1.8797 | |
| SUM185PE | TNBC | Luminal | Methylglyoxal | 13619.184 | uM | 665.77460 | 699.53910 | -0.6332 | -0.1403 | 5.0000 | 0.4759 | 0.5806 | 0.8825 | |||
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 12414.167 | uM | 0.04797 | 0.05925 | -0.9352 | -0.9371 | 5.0000 | 0.9336 | 0.9987 | 1.2130 | |
| MDA-MB-361 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 12379.168 | uM | 128.15820 | 159.58180 | -0.5091 | -0.9968 | 5.0000 | 0.0519 | 0.9920 | 0.4672 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7793.001 | uM | 0.01232 | 0.01448 | -0.9105 | -0.6208 | 5.0000 | 0.9168 | 0.9189 | 1.1508 | |
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5902.067 | uM | 13.20150 | 16.4310 | -0.9807 | -0.9934 | 5.0000 | 0.3462 | 0.9959 | 1.1750 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7473.074 | uM | 0.15419 | 0.18046 | -0.6339 | -0.5980 | 5.0000 | 0.8594 | 0.9948 | 2.5364 | |
| HCC1395 | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 13538.174 | uM | inf | 0.14414 | 0.6866 | 0.6441 | 5.0000 | 0.1678 | 0.7406 | 0.4615 | |
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9254.002 | uM | 0.00740 | 0.00860 | -0.5219 | -0.5591 | 5.0000 | 0.8610 | 0.9829 | 0.3983 | |
| MDA-MB-134-VI | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 10519.14 | uM | inf | 8.4880 | 0.8839 | 0.8826 | 5.0000 | 0.0185 | 0.7338 | 1.0269 | |
| MDA-MB-175-VII | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7500.084 | uM | 106.2680 | 117.60260 | -0.3263 | -0.3299 | 5.0000 | 0.2265 | 0.9836 | 0.5811 | |
| LY2 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 9536.017 | uM | 0.30234 | 0.34796 | -0.9612 | -0.5096 | 5.0000 | 0.6777 | 0.9311 | 1.4526 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7793.001 | uM | 0.02405 | 0.02845 | -0.7415 | -0.6582 | 5.0000 | 0.9064 | 0.9803 | 1.1508 | |
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 12239.16 | uM | inf | 0.98496 | 0.8545 | 0.8502 | 5.0000 | 0.0470 | 0.7642 | 1.8654 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 7486.066 | uM | 6.10380 | 6.67550 | -0.2819 | -0.2824 | 5.0000 | 0.1371 | 0.9935 | 1.0443 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 10643.146 | uM | 1.36050 | 1.50580 | -0.6287 | -0.3306 | 5.0000 | 0.3119 | 0.9352 | 0.6436 | |
| HCC3153 | TNBC | Basal A | Nelfinavir | 13583.174 | uM | 6.17610 | 7.69370 | -1.0000 | -1.0000 | 5.0000 | 0.2044 | 0.9928 | 0.3654 | |||
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5904.067 | uM | 12.39380 | 15.43930 | -0.9979 | -1.0000 | 5.0000 | 0.3909 | 0.9919 | 1.0398 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12291.169 | uM | 2.74420 | 2.49370 | -0.0499 | 0.1902 | 5.0000 | 0.2447 | 0.7269 | 0.3548 | |
| MDA-MB-415 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14272.189 | uM | 2.20420 | 2.67710 | -0.9706 | -0.8214 | 5.0000 | 0.4742 | 0.9888 | 0.5095 | |
| HCC1806 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7830.018 | uM | 0.0220 | 0.02315 | -0.0933 | -0.1447 | 5.0000 | 0.6445 | 0.9806 | 1.5320 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9254.001 | uM | 5.38610 | 6.70950 | -1.0000 | -0.9998 | 5.0000 | 0.3079 | 0.9082 | 0.3986 | |
| MCF12A | NM | Basal B | AS-252424 | PI3K | PI3K | 12365.165 | uM | 34.21190 | 35.76550 | 0.5367 | -0.1243 | 5.0000 | 0.0091 | 0.9694 | 1.9114 |