Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5906.067 | uM | 12.96240 | 16.14770 | -0.9982 | -1.0000 | 5.0000 | 0.3347 | 0.9970 | 0.6838 | |
| MDA-MB-175-VII | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14269.189 | uM | 0.16097 | 0.19121 | -0.9893 | -0.6827 | 5.0000 | 0.8112 | 0.8780 | 0.5173 | |
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 10268.122 | uM | 5.30470 | 5.72240 | -0.2302 | -0.2304 | 5.0000 | 0.1654 | 0.9920 | 0.6345 | ||
| LY2 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12319.17 | uM | 0.22251 | 0.27719 | -0.9999 | -1.0000 | 5.0000 | 0.9111 | 0.9545 | 0.4684 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7451.085 | uM | 0.00695 | 0.00649 | 0.1463 | 0.1465 | 5.0000 | 0.7130 | 0.9890 | 2.1458 | |
| SUM185PE | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 10146.049 | uM | 0.01746 | 0.02114 | -0.8575 | -0.8001 | 5.0000 | 1.1932 | 0.9977 | 0.8861 | |
| Hs 578T | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14158.189 | uM | 0.17168 | 0.18931 | -0.8774 | -0.3153 | 5.0000 | 0.6799 | 0.5842 | 1.7834 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7477.098 | uM | 2.130 | 2.42270 | -0.7323 | -0.4519 | 5.0000 | 0.5164 | 0.8510 | 1.4247 | |
| HCC1937 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7452.074 | uM | 0.03299 | 0.04075 | -0.9545 | -0.9379 | 5.0000 | 1.2681 | 0.9990 | 1.5162 | |
| HCC1937 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 7453.073 | uM | 37.38430 | 32.62130 | 0.2473 | 0.2471 | 5.0000 | 0.0581 | 0.9758 | 1.3837 | |
| HCC1937 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7452.074 | uM | 0.03299 | 0.04075 | -0.9545 | -0.9379 | 5.0000 | 1.2681 | 0.9990 | 1.5162 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10755.153 | uM | 10.12190 | 11.78250 | -0.5684 | -0.5687 | 5.0000 | 0.2778 | 0.9603 | 0.7471 | |
| AU565 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5901.091 | uM | 1.70110 | 1.39940 | 0.2219 | 0.3117 | 5.0000 | 0.2329 | 0.7603 | 1.9229 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 7472.074 | uM | 11.96570 | 14.17630 | -0.6937 | -0.6671 | 5.0000 | 0.3973 | 0.9945 | 1.5922 | |
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 10077.026 | uM | 859.70570 | 1000.00000 | -0.8312 | -0.5647 | 5.0000 | 0.1049 | 0.8794 | 0.3999 | ||
| SUM185PE | TNBC | Luminal | Ibandronate | FDPS | 12269.143 | uM | 160.42990 | 196.12130 | -0.8638 | -0.8651 | 5.0000 | 0.4406 | 0.8751 | 0.3088 | ||
| HCC70 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 7470.093 | uM | 7.20970 | 7.7470 | -0.2154 | -0.2163 | 5.0000 | 0.1443 | 0.9845 | 1.0798 | |
| MCF12A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 10061.037 | uM | 0.03509 | 0.03844 | -0.6495 | -0.2882 | 5.0000 | 0.8377 | 0.6366 | 1.7478 | |
| Hs 578T | TNBC | Basal B | AS-252424 | PI3K | PI3K | 10694.153 | uM | inf | 6.79170 | 0.5918 | 0.5917 | 5.0000 | 0.0456 | 0.9716 | 2.2940 | |
| HCC1937 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7832.04 | uM | 0.11060 | 0.12650 | -0.7120 | -0.4790 | 5.0000 | 0.7532 | 0.9817 | 1.2889 | |
| 600MPE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 12224.152 | uM | 3.0690 | 3.80580 | -0.9666 | -0.9662 | 5.0000 | 0.6239 | 0.9973 | 1.0761 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9035.001 | uM | 0.00071 | 0.00076 | 0.2153 | -0.1767 | 5.0000 | 0.9858 | 0.7915 | 2.4291 | |
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7884.05 | uM | 0.02659 | 0.03251 | -0.9340 | -0.8649 | 5.0000 | 1.1490 | 0.9980 | 0.3869 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9146.001 | uM | 0.01119 | 0.01274 | -0.9678 | -0.4577 | 5.0000 | 0.8676 | 0.8304 | 1.2878 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7813.007 | uM | 0.40394 | 0.43618 | -0.7377 | -0.2341 | 5.0000 | 0.4623 | 0.8679 | 0.8361 |