Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7477.067 | uM | 0.02797 | 0.03324 | -0.9999 | -0.6861 | 5.0000 | 0.8886 | 0.9769 | 0.6787 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7896.016 | uM | 2.41090 | 1.76380 | 0.2423 | 0.3952 | 5.0000 | 0.2011 | 0.9175 | 0.8912 | |
| HCC2185 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 10996.152 | uM | 1.22350 | 1.34990 | -0.3239 | -0.3172 | 5.0000 | 0.3252 | 0.9874 | 0.6343 | |
| HCC3153 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7853.011 | uM | 46.46770 | 52.49410 | -0.5641 | -0.4200 | 5.0000 | 0.3745 | 0.9845 | 1.6331 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 9376.001 | uM | 0.01149 | 0.01275 | -0.8414 | -0.3412 | 5.0000 | 0.7692 | 0.90 | 1.8315 | |
| LY2 | HR+ | Luminal | IKK16 | IKK | NFKB | 10380.093 | uM | 4.96840 | 6.12220 | -0.9112 | -0.9204 | 5.0000 | 0.3282 | 0.9978 | 1.4880 | |
| MCF12A | NM | Basal B | NU6102 | CDK1/2 | CDK | 12365.147 | uM | 37.52320 | 46.74370 | -0.7116 | -1.0000 | 5.0000 | 0.1111 | 0.9860 | 1.8376 | |
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9648.121 | uM | 0.11428 | 0.13646 | -0.9995 | -0.7141 | 5.0000 | 0.8762 | 0.9561 | 0.6537 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7474.098 | uM | 7.61860 | 8.29140 | -0.2613 | -0.2634 | 5.0000 | 0.2237 | 0.9943 | 2.6093 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7857.042 | uM | inf | 0.00139 | 0.7456 | 0.7944 | 5.0000 | 0.1040 | 0.8457 | 1.1910 | |
| HCC38 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7854.016 | uM | 25.43790 | 31.12610 | -0.0924 | -0.8715 | 5.0000 | 0.0515 | 0.9793 | 0.9074 | |
| BT-20 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5903.084 | uM | 64.21230 | 73.43050 | -0.5323 | -0.4778 | 5.0000 | 0.3012 | 0.9916 | 1.2088 | |
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 12400.169 | uM | 0.69220 | 0.70339 | -0.0677 | -0.0418 | 5.0000 | 0.4240 | 0.9528 | 1.2449 | ||
| MDA-MB-175-VII | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7499.084 | uM | 7.87410 | 8.66330 | -0.7584 | -0.3061 | 5.0000 | 0.5234 | 0.7548 | 0.7991 | |
| HCC38 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9453.011 | uM | 34.80390 | 42.89210 | -0.9585 | -0.9214 | 5.0000 | 0.5058 | 0.9973 | 0.7773 | |
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 10073.034 | uM | 869.1580 | 1000.00000 | -0.8708 | -0.5080 | 5.0000 | 0.1985 | 0.7391 | 0.5531 | ||
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 7808.043 | uM | 3.95580 | 3.81630 | -0.1647 | 0.0821 | 5.0000 | 0.2428 | 0.8707 | 2.3907 | |
| MDA-MB-361 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7896.016 | uM | inf | 8.69110 | 0.4955 | 0.6398 | 5.0000 | 0.1295 | 0.6325 | 0.8912 | ||
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 12622.177 | uM | 0.23724 | 0.28366 | -0.7666 | -0.7219 | 5.0000 | 0.6272 | 0.9991 | 2.5433 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 5897.085 | uM | 0.04372 | 0.05133 | -0.6179 | -0.6153 | 5.0000 | 1.1076 | 0.9993 | 1.2392 | |
| SUM159PT | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 13054.174 | uM | 0.14850 | 0.11072 | 0.4517 | 0.3848 | 5.0000 | 0.3095 | 0.8992 | 3.1161 | |
| Hs 578T | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7864.011 | uM | 1.67230 | 1.46940 | 0.1733 | 0.2381 | 5.0000 | 0.2906 | 0.9134 | 1.4831 | |
| MDA-MB-361 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 10999.151 | uM | 0.31174 | 0.34620 | -0.2351 | -0.3446 | 5.0000 | 0.6082 | 0.9731 | 0.7090 | |
| HCC3153 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 13583.174 | uM | 0.07381 | 0.07938 | -1.0000 | -0.2193 | 5.0000 | 0.5952 | 0.7724 | 0.3654 | |
| MB 157 | Unknown | Unknown | NSC 663284 | CDC25 | CDC | 12580.152 | uM | 1.98170 | 2.38630 | -0.7558 | -0.7659 | 5.0000 | 0.5664 | 0.9993 | 2.2597 |